Advanced bioengineering of male germ stem cells to preserve fertility

In modern life, several factors such as genetics, exposure to toxins, and aging have resulted in significant levels of male infertility, estimated to be approximately 18% worldwide. In response, substantial progress has been made to improve in vitro fertilization treatments (e.g. microsurgical testi...

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Autores principales:	Hossein Eyni, Sadegh Ghorbani, Hojjatollah Nazari, Marziyeh Hajialyani, Sajad Razavi Bazaz, Mahdi Mohaqiq, Majid Ebrahimi Warkiani, Duncan S Sutherland
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/bac7f3d7165a4705a6d6fb854ba7e44c
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spelling	oai:doaj.org-article:bac7f3d7165a4705a6d6fb854ba7e44c2021-12-01T00:05:49ZAdvanced bioengineering of male germ stem cells to preserve fertility2041-731410.1177/20417314211060590https://doaj.org/article/bac7f3d7165a4705a6d6fb854ba7e44c2021-11-01T00:00:00Zhttps://doi.org/10.1177/20417314211060590https://doaj.org/toc/2041-7314In modern life, several factors such as genetics, exposure to toxins, and aging have resulted in significant levels of male infertility, estimated to be approximately 18% worldwide. In response, substantial progress has been made to improve in vitro fertilization treatments (e.g. microsurgical testicular sperm extraction (m-TESE), intra-cytoplasmic sperm injection (ICSI), and round spermatid injection (ROSI)). Mimicking the structure of testicular natural extracellular matrices (ECM) outside of the body is one clear route toward complete in vitro spermatogenesis and male fertility preservation. Here, a new wave of technological innovations is underway applying regenerative medicine strategies to cell-tissue culture on natural or synthetic scaffolds supplemented with bioactive factors. The emergence of advanced bioengineered systems suggests new hope for male fertility preservation through development of functional male germ cells. To date, few studies aimed at in vitro spermatogenesis have resulted in relevant numbers of mature gametes. However, a substantial body of knowledge on conditions that are required to maintain and mature male germ cells in vitro is now in place. This review focuses on advanced bioengineering methods such as microfluidic systems, bio-fabricated scaffolds, and 3D organ culture applied to the germline for fertility preservation through in vitro spermatogenesis.Hossein EyniSadegh GhorbaniHojjatollah NazariMarziyeh HajialyaniSajad Razavi BazazMahdi MohaqiqMajid Ebrahimi WarkianiDuncan S SutherlandSAGE PublishingarticleBiochemistryQD415-436ENJournal of Tissue Engineering, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biochemistry QD415-436
spellingShingle	Biochemistry QD415-436 Hossein Eyni Sadegh Ghorbani Hojjatollah Nazari Marziyeh Hajialyani Sajad Razavi Bazaz Mahdi Mohaqiq Majid Ebrahimi Warkiani Duncan S Sutherland Advanced bioengineering of male germ stem cells to preserve fertility
description	In modern life, several factors such as genetics, exposure to toxins, and aging have resulted in significant levels of male infertility, estimated to be approximately 18% worldwide. In response, substantial progress has been made to improve in vitro fertilization treatments (e.g. microsurgical testicular sperm extraction (m-TESE), intra-cytoplasmic sperm injection (ICSI), and round spermatid injection (ROSI)). Mimicking the structure of testicular natural extracellular matrices (ECM) outside of the body is one clear route toward complete in vitro spermatogenesis and male fertility preservation. Here, a new wave of technological innovations is underway applying regenerative medicine strategies to cell-tissue culture on natural or synthetic scaffolds supplemented with bioactive factors. The emergence of advanced bioengineered systems suggests new hope for male fertility preservation through development of functional male germ cells. To date, few studies aimed at in vitro spermatogenesis have resulted in relevant numbers of mature gametes. However, a substantial body of knowledge on conditions that are required to maintain and mature male germ cells in vitro is now in place. This review focuses on advanced bioengineering methods such as microfluidic systems, bio-fabricated scaffolds, and 3D organ culture applied to the germline for fertility preservation through in vitro spermatogenesis.
format	article
author	Hossein Eyni Sadegh Ghorbani Hojjatollah Nazari Marziyeh Hajialyani Sajad Razavi Bazaz Mahdi Mohaqiq Majid Ebrahimi Warkiani Duncan S Sutherland
author_facet	Hossein Eyni Sadegh Ghorbani Hojjatollah Nazari Marziyeh Hajialyani Sajad Razavi Bazaz Mahdi Mohaqiq Majid Ebrahimi Warkiani Duncan S Sutherland
author_sort	Hossein Eyni
title	Advanced bioengineering of male germ stem cells to preserve fertility
title_short	Advanced bioengineering of male germ stem cells to preserve fertility
title_full	Advanced bioengineering of male germ stem cells to preserve fertility
title_fullStr	Advanced bioengineering of male germ stem cells to preserve fertility
title_full_unstemmed	Advanced bioengineering of male germ stem cells to preserve fertility
title_sort	advanced bioengineering of male germ stem cells to preserve fertility
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/bac7f3d7165a4705a6d6fb854ba7e44c
work_keys_str_mv	AT hosseineyni advancedbioengineeringofmalegermstemcellstopreservefertility AT sadeghghorbani advancedbioengineeringofmalegermstemcellstopreservefertility AT hojjatollahnazari advancedbioengineeringofmalegermstemcellstopreservefertility AT marziyehhajialyani advancedbioengineeringofmalegermstemcellstopreservefertility AT sajadrazavibazaz advancedbioengineeringofmalegermstemcellstopreservefertility AT mahdimohaqiq advancedbioengineeringofmalegermstemcellstopreservefertility AT majidebrahimiwarkiani advancedbioengineeringofmalegermstemcellstopreservefertility AT duncanssutherland advancedbioengineeringofmalegermstemcellstopreservefertility
_version_	1718406161349214208

Advanced bioengineering of male germ stem cells to preserve fertility

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