CPNE3 moderates the association between anxiety and working memory

Abstract Mutual influences between anxiety and working memory (WM) have been extensively studied, and their curvilinear relationship resembles the classic Yerkes-Dodson law of arousal and performance. Given the genetic bases of both anxiety and WM, it is likely that the individual differences in the...

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Autores principales:	Chunhui Chen, Ziyi Wang, Chuansheng Chen, Gui Xue, Shuzhen Lu, Hejun Liu, Qi Dong, Mingxia Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bac8ffea02714d9a93399a6602c42218
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spelling	oai:doaj.org-article:bac8ffea02714d9a93399a6602c422182021-12-02T11:45:04ZCPNE3 moderates the association between anxiety and working memory10.1038/s41598-021-86263-62045-2322https://doaj.org/article/bac8ffea02714d9a93399a6602c422182021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86263-6https://doaj.org/toc/2045-2322Abstract Mutual influences between anxiety and working memory (WM) have been extensively studied, and their curvilinear relationship resembles the classic Yerkes-Dodson law of arousal and performance. Given the genetic bases of both anxiety and WM, it is likely that the individual differences in the Yerkes-Dodson law of anxiety and WM may have genetic correlates. The current genome wide association study (GWAS) enrolled 1115 healthy subjects to search for genes that are potential moderators of the association between anxiety and WM. Results showed that CPNE3 rs10102229 had the strongest effect, p = 3.38E−6 at SNP level and p = 2.68E−06 at gene level. Anxiety and WM had a significant negative correlation (i.e., more anxious individuals performed worse on the WM tasks) for the TT genotype of rs10102229 (resulting in lower expression of CPNE3), whereas the correlation was positive (i.e., more anxious individuals performed better on the WM tasks) for the CC carriers. The same pattern of results was found at the gene level using gene score analysis. These effects were replicated in an independent sample (N = 330). The current study is the first to report a gene that moderates the relation between anxiety and WM and potentially provides a genetic explanation for the classic Yerkes-Dodson law.Chunhui ChenZiyi WangChuansheng ChenGui XueShuzhen LuHejun LiuQi DongMingxia ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chunhui Chen Ziyi Wang Chuansheng Chen Gui Xue Shuzhen Lu Hejun Liu Qi Dong Mingxia Zhang CPNE3 moderates the association between anxiety and working memory
description	Abstract Mutual influences between anxiety and working memory (WM) have been extensively studied, and their curvilinear relationship resembles the classic Yerkes-Dodson law of arousal and performance. Given the genetic bases of both anxiety and WM, it is likely that the individual differences in the Yerkes-Dodson law of anxiety and WM may have genetic correlates. The current genome wide association study (GWAS) enrolled 1115 healthy subjects to search for genes that are potential moderators of the association between anxiety and WM. Results showed that CPNE3 rs10102229 had the strongest effect, p = 3.38E−6 at SNP level and p = 2.68E−06 at gene level. Anxiety and WM had a significant negative correlation (i.e., more anxious individuals performed worse on the WM tasks) for the TT genotype of rs10102229 (resulting in lower expression of CPNE3), whereas the correlation was positive (i.e., more anxious individuals performed better on the WM tasks) for the CC carriers. The same pattern of results was found at the gene level using gene score analysis. These effects were replicated in an independent sample (N = 330). The current study is the first to report a gene that moderates the relation between anxiety and WM and potentially provides a genetic explanation for the classic Yerkes-Dodson law.
format	article
author	Chunhui Chen Ziyi Wang Chuansheng Chen Gui Xue Shuzhen Lu Hejun Liu Qi Dong Mingxia Zhang
author_facet	Chunhui Chen Ziyi Wang Chuansheng Chen Gui Xue Shuzhen Lu Hejun Liu Qi Dong Mingxia Zhang
author_sort	Chunhui Chen
title	CPNE3 moderates the association between anxiety and working memory
title_short	CPNE3 moderates the association between anxiety and working memory
title_full	CPNE3 moderates the association between anxiety and working memory
title_fullStr	CPNE3 moderates the association between anxiety and working memory
title_full_unstemmed	CPNE3 moderates the association between anxiety and working memory
title_sort	cpne3 moderates the association between anxiety and working memory
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bac8ffea02714d9a93399a6602c42218
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_version_	1718395306399236096

CPNE3 moderates the association between anxiety and working memory

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