Multimodality analysis of Hyper-reflective Foci and Hard Exudates in Patients with Diabetic Retinopathy

Abstract To investigate the correlations between hyper-reflective foci and hard exudates in patients with non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) by spectral-domain optical coherence tomography (SD OCT) images. Hyper-reflective foci in retinal SD OC...

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Autores principales:	Sijie Niu, Chenchen Yu, Qiang Chen, Songtao Yuan, Jiang Lin, Wen Fan, Qinghuai Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bac98d98e3034b4bb94386d4f4790f3f
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spelling	oai:doaj.org-article:bac98d98e3034b4bb94386d4f4790f3f2021-12-02T16:06:01ZMultimodality analysis of Hyper-reflective Foci and Hard Exudates in Patients with Diabetic Retinopathy10.1038/s41598-017-01733-02045-2322https://doaj.org/article/bac98d98e3034b4bb94386d4f4790f3f2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01733-0https://doaj.org/toc/2045-2322Abstract To investigate the correlations between hyper-reflective foci and hard exudates in patients with non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) by spectral-domain optical coherence tomography (SD OCT) images. Hyper-reflective foci in retinal SD OCT images were automatically detected by the developed algorithm. Then, the cropped CFP images generated by the semi-automatic registration method were automatically segmented for the hard exudates and corrected by the experienced clinical ophthalmologist. Finally, a set of 5 quantitative imaging features were automatically extracted from SD OCT images, which were used for investigating the correlations of hyper-reflective foci and hard exudates and predicting the severity of diabetic retinopathy. Experimental results demonstrated the positive correlations in area and amount between hard exudates and hyper-reflective foci at different stages of diabetic retinopathy, with statistical significance (all p < 0.05). In addition, the area and amount can be taken as potential discriminant indicators of the severity of diabetic retinopathy.Sijie NiuChenchen YuQiang ChenSongtao YuanJiang LinWen FanQinghuai LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sijie Niu Chenchen Yu Qiang Chen Songtao Yuan Jiang Lin Wen Fan Qinghuai Liu Multimodality analysis of Hyper-reflective Foci and Hard Exudates in Patients with Diabetic Retinopathy
description	Abstract To investigate the correlations between hyper-reflective foci and hard exudates in patients with non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) by spectral-domain optical coherence tomography (SD OCT) images. Hyper-reflective foci in retinal SD OCT images were automatically detected by the developed algorithm. Then, the cropped CFP images generated by the semi-automatic registration method were automatically segmented for the hard exudates and corrected by the experienced clinical ophthalmologist. Finally, a set of 5 quantitative imaging features were automatically extracted from SD OCT images, which were used for investigating the correlations of hyper-reflective foci and hard exudates and predicting the severity of diabetic retinopathy. Experimental results demonstrated the positive correlations in area and amount between hard exudates and hyper-reflective foci at different stages of diabetic retinopathy, with statistical significance (all p < 0.05). In addition, the area and amount can be taken as potential discriminant indicators of the severity of diabetic retinopathy.
format	article
author	Sijie Niu Chenchen Yu Qiang Chen Songtao Yuan Jiang Lin Wen Fan Qinghuai Liu
author_facet	Sijie Niu Chenchen Yu Qiang Chen Songtao Yuan Jiang Lin Wen Fan Qinghuai Liu
author_sort	Sijie Niu
title	Multimodality analysis of Hyper-reflective Foci and Hard Exudates in Patients with Diabetic Retinopathy
title_short	Multimodality analysis of Hyper-reflective Foci and Hard Exudates in Patients with Diabetic Retinopathy
title_full	Multimodality analysis of Hyper-reflective Foci and Hard Exudates in Patients with Diabetic Retinopathy
title_fullStr	Multimodality analysis of Hyper-reflective Foci and Hard Exudates in Patients with Diabetic Retinopathy
title_full_unstemmed	Multimodality analysis of Hyper-reflective Foci and Hard Exudates in Patients with Diabetic Retinopathy
title_sort	multimodality analysis of hyper-reflective foci and hard exudates in patients with diabetic retinopathy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bac98d98e3034b4bb94386d4f4790f3f
work_keys_str_mv	AT sijieniu multimodalityanalysisofhyperreflectivefociandhardexudatesinpatientswithdiabeticretinopathy AT chenchenyu multimodalityanalysisofhyperreflectivefociandhardexudatesinpatientswithdiabeticretinopathy AT qiangchen multimodalityanalysisofhyperreflectivefociandhardexudatesinpatientswithdiabeticretinopathy AT songtaoyuan multimodalityanalysisofhyperreflectivefociandhardexudatesinpatientswithdiabeticretinopathy AT jianglin multimodalityanalysisofhyperreflectivefociandhardexudatesinpatientswithdiabeticretinopathy AT wenfan multimodalityanalysisofhyperreflectivefociandhardexudatesinpatientswithdiabeticretinopathy AT qinghuailiu multimodalityanalysisofhyperreflectivefociandhardexudatesinpatientswithdiabeticretinopathy
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Multimodality analysis of Hyper-reflective Foci and Hard Exudates in Patients with Diabetic Retinopathy

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