Reduced cell size, chromosomal aberration and altered proliferation rates are characteristics and confounding factors in the STHdh cell model of Huntington disease

Reduced cell size, chromosomal aberration and altered proliferation rates are characteristics and confounding factors in the STHdh cell model of Huntington disease

Abstract Huntington disease is a fatal neurodegenerative disorder caused by a CAG repeat expansion in the gene encoding the huntingtin protein. Expression of the mutant protein disrupts various intracellular pathways and impairs overall cell function. In particular striatal neurons seem to be most v...

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Autores principales: Elisabeth Singer, Carolin Walter, Jonasz J. Weber, Ann-Christin Krahl, Ulrike A. Mau-Holzmann, Nadine Rischert, Olaf Riess, Laura E. Clemensson, Huu P. Nguyen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/baca3f0edb594d1fb92d80a01ad67420
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