Designing a norepinephrine optical tracer for imaging individual noradrenergic synapses and their activity in vivo

The noradrenergic system plays numerous physiological roles but tools to study it are scarce. Here the authors develop a fluorescent analogue of norepinephrine that can be used to label noradrenergic neurons and the synaptic vesicles, and use it to measure single synaptic vesicle release sites in li...

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Autores principales: Matthew Dunn, Adam Henke, Samuel Clark, Yekaterina Kovalyova, Kimberly A. Kempadoo, Richard J. Karpowicz, Eric R. Kandel, David Sulzer, Dalibor Sames
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/bace60ad7e2a435b90bdc647f50746aa
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