Structural basis for tuning activity and membrane specificity of bacterial cytolysins

Cholesterol-dependent cytolysins (CDCs) are bacterial pore-forming virulence factors. Cryo-EM structure of an early conformation of the CDC ILY from Streptococcus intermedius, bound to the human immune receptor CD59, provides insight into ILY oligomerization and role of cholesterol in membrane lysis...

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Autores principales:	Nita R. Shah, Tomas B. Voisin, Edward S. Parsons, Courtney M. Boyd, Bart W. Hoogenboom, Doryen Bubeck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bad042a16128475abd06082cd212d8e7
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spelling	oai:doaj.org-article:bad042a16128475abd06082cd212d8e72021-12-02T14:42:30ZStructural basis for tuning activity and membrane specificity of bacterial cytolysins10.1038/s41467-020-19482-62041-1723https://doaj.org/article/bad042a16128475abd06082cd212d8e72020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19482-6https://doaj.org/toc/2041-1723Cholesterol-dependent cytolysins (CDCs) are bacterial pore-forming virulence factors. Cryo-EM structure of an early conformation of the CDC ILY from Streptococcus intermedius, bound to the human immune receptor CD59, provides insight into ILY oligomerization and role of cholesterol in membrane lysis.Nita R. ShahTomas B. VoisinEdward S. ParsonsCourtney M. BoydBart W. HoogenboomDoryen BubeckNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nita R. Shah Tomas B. Voisin Edward S. Parsons Courtney M. Boyd Bart W. Hoogenboom Doryen Bubeck Structural basis for tuning activity and membrane specificity of bacterial cytolysins
description	Cholesterol-dependent cytolysins (CDCs) are bacterial pore-forming virulence factors. Cryo-EM structure of an early conformation of the CDC ILY from Streptococcus intermedius, bound to the human immune receptor CD59, provides insight into ILY oligomerization and role of cholesterol in membrane lysis.
format	article
author	Nita R. Shah Tomas B. Voisin Edward S. Parsons Courtney M. Boyd Bart W. Hoogenboom Doryen Bubeck
author_facet	Nita R. Shah Tomas B. Voisin Edward S. Parsons Courtney M. Boyd Bart W. Hoogenboom Doryen Bubeck
author_sort	Nita R. Shah
title	Structural basis for tuning activity and membrane specificity of bacterial cytolysins
title_short	Structural basis for tuning activity and membrane specificity of bacterial cytolysins
title_full	Structural basis for tuning activity and membrane specificity of bacterial cytolysins
title_fullStr	Structural basis for tuning activity and membrane specificity of bacterial cytolysins
title_full_unstemmed	Structural basis for tuning activity and membrane specificity of bacterial cytolysins
title_sort	structural basis for tuning activity and membrane specificity of bacterial cytolysins
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bad042a16128475abd06082cd212d8e7
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Structural basis for tuning activity and membrane specificity of bacterial cytolysins

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