Mitochondrial supercomplex assembly promotes breast and endometrial tumorigenesis by metabolic alterations and enhanced hypoxia tolerance

Cancer cells rely on mitochondrial respiration to satisfy their metabolic demands. Here the authors show that the mitochondrial supercomplex assembly factor COX7RP is abundantly expressed in breast and endometrial cancer cells and promotes tumor growth and hypoxia tolerance partially by altering lev...

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Autores principales:	Kazuhiro Ikeda, Kuniko Horie-Inoue, Takashi Suzuki, Rutsuko Hobo, Norie Nakasato, Satoru Takeda, Satoshi Inoue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bad10cef981742fbab5db0b208752c93
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spelling	oai:doaj.org-article:bad10cef981742fbab5db0b208752c932021-12-02T17:32:23ZMitochondrial supercomplex assembly promotes breast and endometrial tumorigenesis by metabolic alterations and enhanced hypoxia tolerance10.1038/s41467-019-12124-62041-1723https://doaj.org/article/bad10cef981742fbab5db0b208752c932019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12124-6https://doaj.org/toc/2041-1723Cancer cells rely on mitochondrial respiration to satisfy their metabolic demands. Here the authors show that the mitochondrial supercomplex assembly factor COX7RP is abundantly expressed in breast and endometrial cancer cells and promotes tumor growth and hypoxia tolerance partially by altering levels of the tricarboxylic acid cycle intermediates.Kazuhiro IkedaKuniko Horie-InoueTakashi SuzukiRutsuko HoboNorie NakasatoSatoru TakedaSatoshi InoueNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kazuhiro Ikeda Kuniko Horie-Inoue Takashi Suzuki Rutsuko Hobo Norie Nakasato Satoru Takeda Satoshi Inoue Mitochondrial supercomplex assembly promotes breast and endometrial tumorigenesis by metabolic alterations and enhanced hypoxia tolerance
description	Cancer cells rely on mitochondrial respiration to satisfy their metabolic demands. Here the authors show that the mitochondrial supercomplex assembly factor COX7RP is abundantly expressed in breast and endometrial cancer cells and promotes tumor growth and hypoxia tolerance partially by altering levels of the tricarboxylic acid cycle intermediates.
format	article
author	Kazuhiro Ikeda Kuniko Horie-Inoue Takashi Suzuki Rutsuko Hobo Norie Nakasato Satoru Takeda Satoshi Inoue
author_facet	Kazuhiro Ikeda Kuniko Horie-Inoue Takashi Suzuki Rutsuko Hobo Norie Nakasato Satoru Takeda Satoshi Inoue
author_sort	Kazuhiro Ikeda
title	Mitochondrial supercomplex assembly promotes breast and endometrial tumorigenesis by metabolic alterations and enhanced hypoxia tolerance
title_short	Mitochondrial supercomplex assembly promotes breast and endometrial tumorigenesis by metabolic alterations and enhanced hypoxia tolerance
title_full	Mitochondrial supercomplex assembly promotes breast and endometrial tumorigenesis by metabolic alterations and enhanced hypoxia tolerance
title_fullStr	Mitochondrial supercomplex assembly promotes breast and endometrial tumorigenesis by metabolic alterations and enhanced hypoxia tolerance
title_full_unstemmed	Mitochondrial supercomplex assembly promotes breast and endometrial tumorigenesis by metabolic alterations and enhanced hypoxia tolerance
title_sort	mitochondrial supercomplex assembly promotes breast and endometrial tumorigenesis by metabolic alterations and enhanced hypoxia tolerance
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bad10cef981742fbab5db0b208752c93
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Mitochondrial supercomplex assembly promotes breast and endometrial tumorigenesis by metabolic alterations and enhanced hypoxia tolerance

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