Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza

Abstract While several studies have described the clinical course of patients with coronavirus disease 2019 (COVID-19), direct comparisons with patients with seasonal influenza are scarce. We compared 166 patients with COVID-19 diagnosed between February 27 and June 14, 2020, and 255 patients with s...

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Autores principales:	Thomas Theo Brehm, Marc van der Meirschen, Annette Hennigs, Kevin Roedl, Dominik Jarczak, Dominic Wichmann, Daniel Frings, Axel Nierhaus, Tim Oqueka, Walter Fiedler, Maximilian Christopeit, Christian Kraef, Alexander Schultze, Marc Lütgehetmann, Marylyn M Addo, Stefan Schmiedel, Stefan Kluge, Julian Schulze zur Wiesch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bad57a05f85249a9bde2f767c45d1984
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spelling	oai:doaj.org-article:bad57a05f85249a9bde2f767c45d19842021-12-02T13:33:44ZComparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza10.1038/s41598-021-85081-02045-2322https://doaj.org/article/bad57a05f85249a9bde2f767c45d19842021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85081-0https://doaj.org/toc/2045-2322Abstract While several studies have described the clinical course of patients with coronavirus disease 2019 (COVID-19), direct comparisons with patients with seasonal influenza are scarce. We compared 166 patients with COVID-19 diagnosed between February 27 and June 14, 2020, and 255 patients with seasonal influenza diagnosed during the 2017–18 season at the same hospital to describe common features and differences in clinical characteristics and course of disease. Patients with COVID-19 were younger (median age [IQR], 59 [45–71] vs 66 [52–77]; P < 0001) and had fewer comorbidities at baseline with a lower mean overall age-adjusted Charlson Comorbidity Index (mean [SD], 3.0 [2.6] vs 4.0 [2.7]; P < 0.001) than patients with seasonal influenza. COVID-19 patients had a longer duration of hospitalization (mean [SD], 25.9 days [26.6 days] vs 17.2 days [21.0 days]; P = 0.002), a more frequent need for oxygen therapy (101 [60.8%] vs 103 [40.4%]; P < 0.001) and invasive ventilation (52 [31.3%] vs 32 [12.5%]; P < 0.001) and were more frequently admitted to the intensive care unit (70 [42.2%] vs 51 [20.0%]; P < 0.001) than seasonal influenza patients. Among immunocompromised patients, those in the COVID-19 group had a higher hospital mortality compared to those in the seasonal influenza group (13 [33.3%] vs 8 [11.6%], P = 0.01). In conclusion, we show that COVID-19 patients were younger and had fewer baseline comorbidities than seasonal influenza patients but were at increased risk for severe illness. The high mortality observed in immunocompromised COVID-19 patients emphasizes the importance of protecting these patient groups from SARS-CoV-2 infection.Thomas Theo BrehmMarc van der MeirschenAnnette HennigsKevin RoedlDominik JarczakDominic WichmannDaniel FringsAxel NierhausTim OquekaWalter FiedlerMaximilian ChristopeitChristian KraefAlexander SchultzeMarc LütgehetmannMarylyn M AddoStefan SchmiedelStefan KlugeJulian Schulze zur WieschNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Thomas Theo Brehm Marc van der Meirschen Annette Hennigs Kevin Roedl Dominik Jarczak Dominic Wichmann Daniel Frings Axel Nierhaus Tim Oqueka Walter Fiedler Maximilian Christopeit Christian Kraef Alexander Schultze Marc Lütgehetmann Marylyn M Addo Stefan Schmiedel Stefan Kluge Julian Schulze zur Wiesch Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza
description	Abstract While several studies have described the clinical course of patients with coronavirus disease 2019 (COVID-19), direct comparisons with patients with seasonal influenza are scarce. We compared 166 patients with COVID-19 diagnosed between February 27 and June 14, 2020, and 255 patients with seasonal influenza diagnosed during the 2017–18 season at the same hospital to describe common features and differences in clinical characteristics and course of disease. Patients with COVID-19 were younger (median age [IQR], 59 [45–71] vs 66 [52–77]; P < 0001) and had fewer comorbidities at baseline with a lower mean overall age-adjusted Charlson Comorbidity Index (mean [SD], 3.0 [2.6] vs 4.0 [2.7]; P < 0.001) than patients with seasonal influenza. COVID-19 patients had a longer duration of hospitalization (mean [SD], 25.9 days [26.6 days] vs 17.2 days [21.0 days]; P = 0.002), a more frequent need for oxygen therapy (101 [60.8%] vs 103 [40.4%]; P < 0.001) and invasive ventilation (52 [31.3%] vs 32 [12.5%]; P < 0.001) and were more frequently admitted to the intensive care unit (70 [42.2%] vs 51 [20.0%]; P < 0.001) than seasonal influenza patients. Among immunocompromised patients, those in the COVID-19 group had a higher hospital mortality compared to those in the seasonal influenza group (13 [33.3%] vs 8 [11.6%], P = 0.01). In conclusion, we show that COVID-19 patients were younger and had fewer baseline comorbidities than seasonal influenza patients but were at increased risk for severe illness. The high mortality observed in immunocompromised COVID-19 patients emphasizes the importance of protecting these patient groups from SARS-CoV-2 infection.
format	article
author	Thomas Theo Brehm Marc van der Meirschen Annette Hennigs Kevin Roedl Dominik Jarczak Dominic Wichmann Daniel Frings Axel Nierhaus Tim Oqueka Walter Fiedler Maximilian Christopeit Christian Kraef Alexander Schultze Marc Lütgehetmann Marylyn M Addo Stefan Schmiedel Stefan Kluge Julian Schulze zur Wiesch
author_facet	Thomas Theo Brehm Marc van der Meirschen Annette Hennigs Kevin Roedl Dominik Jarczak Dominic Wichmann Daniel Frings Axel Nierhaus Tim Oqueka Walter Fiedler Maximilian Christopeit Christian Kraef Alexander Schultze Marc Lütgehetmann Marylyn M Addo Stefan Schmiedel Stefan Kluge Julian Schulze zur Wiesch
author_sort	Thomas Theo Brehm
title	Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza
title_short	Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza
title_full	Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza
title_fullStr	Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza
title_full_unstemmed	Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza
title_sort	comparison of clinical characteristics and disease outcome of covid-19 and seasonal influenza
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bad57a05f85249a9bde2f767c45d1984
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Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza

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