Critical appraisal of once-weekly formulation of exenatide in the control of type 2 diabetes mellitus

Jason Seewoodhary1, Leanne Griffin1, Stephen C Bain11Department of Diabetes and Endocrinology, Swansea School of Medicine, University of Wales, Swansea SA2 8PP, UKAbstract: Exenatide (also known as exendin-4) is a glucagon-like peptide-1 mimetic, which is indicated for the treatment of type 2 diabet...

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Autores principales: Seewoodhary J, Griffin, Bain S
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Publicado: Dove Medical Press 2010
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spelling oai:doaj.org-article:bad96351b7d74267b44ac891c70c9d992021-12-02T00:35:50ZCritical appraisal of once-weekly formulation of exenatide in the control of type 2 diabetes mellitus1178-7007https://doaj.org/article/bad96351b7d74267b44ac891c70c9d992010-05-01T00:00:00Zhttps://www.dovepress.com/critical-appraisal-of-once-weekly-formulation-of-exenatide-in-the-cont-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Jason Seewoodhary1, Leanne Griffin1, Stephen C Bain11Department of Diabetes and Endocrinology, Swansea School of Medicine, University of Wales, Swansea SA2 8PP, UKAbstract: Exenatide (also known as exendin-4) is a glucagon-like peptide-1 mimetic, which is indicated for the treatment of type 2 diabetes mellitus. The currently available formulation of this drug is a twice-daily exenatide (exenatide BID) injection that should be administered within 60 minutes of food. Once-weekly exenatide (exenatide QW) formulation is now being assessed in a clinical trial program. Exenatide QW has been shown to be the only noninsulin monotherapy to achieve glycosylated hemoglobin levels of <7% in >75% of treated patients. It has also demonstrated potential cardiovascular benefits by lowering total and low-density lipoprotein cholesterol concentrations, triglyceride levels, and both systolic and diastolic blood pressure. In addition, patients treated with exenatide QW achieved significant weight loss, which may also lead to significant cardiovascular risk reduction. Exenatide QW is associated with a lower incidence of gastrointestinal adverse effects compared with exenatide BID, and no patients treated with exenatide QW monotherapy experienced a confirmed hypoglycemic event. Exenatide QW results in 24-hour coverage with exenatide concentrations that are known to improve glycemic control and remain well tolerated in patients with type 2 diabetes mellitus. This review defines the state of play with exenatide QW by critically appraising its role in clinical practice.Keywords: GLP-1 mimetic, HbA1c, weight lossSeewoodhary JGriffinBain SDove Medical PressarticleType 2 DiabetesExenatide QWGLP-1 mimeticHbA1CWeight lossSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 3, Pp 165-172 (2010)
institution DOAJ
collection DOAJ
language EN
topic Type 2 Diabetes
Exenatide QW
GLP-1 mimetic
HbA1C
Weight loss
Specialties of internal medicine
RC581-951
spellingShingle Type 2 Diabetes
Exenatide QW
GLP-1 mimetic
HbA1C
Weight loss
Specialties of internal medicine
RC581-951
Seewoodhary J
Griffin
Bain S
Critical appraisal of once-weekly formulation of exenatide in the control of type 2 diabetes mellitus
description Jason Seewoodhary1, Leanne Griffin1, Stephen C Bain11Department of Diabetes and Endocrinology, Swansea School of Medicine, University of Wales, Swansea SA2 8PP, UKAbstract: Exenatide (also known as exendin-4) is a glucagon-like peptide-1 mimetic, which is indicated for the treatment of type 2 diabetes mellitus. The currently available formulation of this drug is a twice-daily exenatide (exenatide BID) injection that should be administered within 60 minutes of food. Once-weekly exenatide (exenatide QW) formulation is now being assessed in a clinical trial program. Exenatide QW has been shown to be the only noninsulin monotherapy to achieve glycosylated hemoglobin levels of <7% in >75% of treated patients. It has also demonstrated potential cardiovascular benefits by lowering total and low-density lipoprotein cholesterol concentrations, triglyceride levels, and both systolic and diastolic blood pressure. In addition, patients treated with exenatide QW achieved significant weight loss, which may also lead to significant cardiovascular risk reduction. Exenatide QW is associated with a lower incidence of gastrointestinal adverse effects compared with exenatide BID, and no patients treated with exenatide QW monotherapy experienced a confirmed hypoglycemic event. Exenatide QW results in 24-hour coverage with exenatide concentrations that are known to improve glycemic control and remain well tolerated in patients with type 2 diabetes mellitus. This review defines the state of play with exenatide QW by critically appraising its role in clinical practice.Keywords: GLP-1 mimetic, HbA1c, weight loss
format article
author Seewoodhary J
Griffin
Bain S
author_facet Seewoodhary J
Griffin
Bain S
author_sort Seewoodhary J
title Critical appraisal of once-weekly formulation of exenatide in the control of type 2 diabetes mellitus
title_short Critical appraisal of once-weekly formulation of exenatide in the control of type 2 diabetes mellitus
title_full Critical appraisal of once-weekly formulation of exenatide in the control of type 2 diabetes mellitus
title_fullStr Critical appraisal of once-weekly formulation of exenatide in the control of type 2 diabetes mellitus
title_full_unstemmed Critical appraisal of once-weekly formulation of exenatide in the control of type 2 diabetes mellitus
title_sort critical appraisal of once-weekly formulation of exenatide in the control of type 2 diabetes mellitus
publisher Dove Medical Press
publishDate 2010
url https://doaj.org/article/bad96351b7d74267b44ac891c70c9d99
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