Resveratrol against Cardiac Fibrosis: Research Progress in Experimental Animal Models

Cardiac fibrosis is a heterogeneous disease, which is characterized by abundant proliferation of interstitial collagen, disordered arrangement, collagen network reconstruction, increased cardiac stiffness, and decreased systolic and diastolic functions, consequently developing into cardiac insuffici...

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Autores principales:	Dongmin Yu, Zhixian Tang, Ben Li, Junjian Yu, Wentong Li, Ziyou Liu, Chengnan Tian
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	resveratrol cardiac fibrosis cardiac fibrosis-related diseases Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/bada4423efb1405fb81842d7d61d37fa
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spelling	oai:doaj.org-article:bada4423efb1405fb81842d7d61d37fa2021-11-25T18:27:53ZResveratrol against Cardiac Fibrosis: Research Progress in Experimental Animal Models10.3390/molecules262268601420-3049https://doaj.org/article/bada4423efb1405fb81842d7d61d37fa2021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6860https://doaj.org/toc/1420-3049Cardiac fibrosis is a heterogeneous disease, which is characterized by abundant proliferation of interstitial collagen, disordered arrangement, collagen network reconstruction, increased cardiac stiffness, and decreased systolic and diastolic functions, consequently developing into cardiac insufficiency. With several factors participating in and regulating the occurrence and development of cardiac fibrosis, a complex molecular mechanism underlies the disease. Moreover, cardiac fibrosis is closely related to hypertension, myocardial infarction, viral myocarditis, atherosclerosis, and diabetes, which can lead to serious complications such as heart failure, arrhythmia, and sudden cardiac death, thus seriously threatening human life and health. Resveratrol, with the chemical name 3,5,4′-trihydroxy-trans-stilbene, is a polyphenol abundantly present in grapes and red wine. It is known to prevent the occurrence and development of cardiovascular diseases. In addition, it may resist cardiac fibrosis through a variety of growth factors, cytokines, and several cell signaling pathways, thus exerting a protective effect on the heart.Dongmin YuZhixian TangBen LiJunjian YuWentong LiZiyou LiuChengnan TianMDPI AGarticleresveratrolcardiac fibrosiscardiac fibrosis-related diseasesOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6860, p 6860 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	resveratrol cardiac fibrosis cardiac fibrosis-related diseases Organic chemistry QD241-441
spellingShingle	resveratrol cardiac fibrosis cardiac fibrosis-related diseases Organic chemistry QD241-441 Dongmin Yu Zhixian Tang Ben Li Junjian Yu Wentong Li Ziyou Liu Chengnan Tian Resveratrol against Cardiac Fibrosis: Research Progress in Experimental Animal Models
description	Cardiac fibrosis is a heterogeneous disease, which is characterized by abundant proliferation of interstitial collagen, disordered arrangement, collagen network reconstruction, increased cardiac stiffness, and decreased systolic and diastolic functions, consequently developing into cardiac insufficiency. With several factors participating in and regulating the occurrence and development of cardiac fibrosis, a complex molecular mechanism underlies the disease. Moreover, cardiac fibrosis is closely related to hypertension, myocardial infarction, viral myocarditis, atherosclerosis, and diabetes, which can lead to serious complications such as heart failure, arrhythmia, and sudden cardiac death, thus seriously threatening human life and health. Resveratrol, with the chemical name 3,5,4′-trihydroxy-trans-stilbene, is a polyphenol abundantly present in grapes and red wine. It is known to prevent the occurrence and development of cardiovascular diseases. In addition, it may resist cardiac fibrosis through a variety of growth factors, cytokines, and several cell signaling pathways, thus exerting a protective effect on the heart.
format	article
author	Dongmin Yu Zhixian Tang Ben Li Junjian Yu Wentong Li Ziyou Liu Chengnan Tian
author_facet	Dongmin Yu Zhixian Tang Ben Li Junjian Yu Wentong Li Ziyou Liu Chengnan Tian
author_sort	Dongmin Yu
title	Resveratrol against Cardiac Fibrosis: Research Progress in Experimental Animal Models
title_short	Resveratrol against Cardiac Fibrosis: Research Progress in Experimental Animal Models
title_full	Resveratrol against Cardiac Fibrosis: Research Progress in Experimental Animal Models
title_fullStr	Resveratrol against Cardiac Fibrosis: Research Progress in Experimental Animal Models
title_full_unstemmed	Resveratrol against Cardiac Fibrosis: Research Progress in Experimental Animal Models
title_sort	resveratrol against cardiac fibrosis: research progress in experimental animal models
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bada4423efb1405fb81842d7d61d37fa
work_keys_str_mv	AT dongminyu resveratrolagainstcardiacfibrosisresearchprogressinexperimentalanimalmodels AT zhixiantang resveratrolagainstcardiacfibrosisresearchprogressinexperimentalanimalmodels AT benli resveratrolagainstcardiacfibrosisresearchprogressinexperimentalanimalmodels AT junjianyu resveratrolagainstcardiacfibrosisresearchprogressinexperimentalanimalmodels AT wentongli resveratrolagainstcardiacfibrosisresearchprogressinexperimentalanimalmodels AT ziyouliu resveratrolagainstcardiacfibrosisresearchprogressinexperimentalanimalmodels AT chengnantian resveratrolagainstcardiacfibrosisresearchprogressinexperimentalanimalmodels
_version_	1718411154645057536

Resveratrol against Cardiac Fibrosis: Research Progress in Experimental Animal Models

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