Predicting chromosome damage in astronauts participating in international space station missions

Abstract Space radiation consists of energetic protons and other heavier ions. During the International Space Station program, chromosome aberrations in lymphocytes of astronauts have been analyzed to estimate received biological doses of space radiation. More specifically, pre-flight blood samples...

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Autores principales:	Alan Feiveson, Kerry George, Mark Shavers, Maria Moreno-Villanueva, Ye Zhang, Adriana Babiak-Vazquez, Brian Crucian, Edward Semones, Honglu Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bade7148abc2402f9e8c4d6c3b98ddad
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spelling	oai:doaj.org-article:bade7148abc2402f9e8c4d6c3b98ddad2021-12-02T13:20:14ZPredicting chromosome damage in astronauts participating in international space station missions10.1038/s41598-021-84242-52045-2322https://doaj.org/article/bade7148abc2402f9e8c4d6c3b98ddad2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84242-5https://doaj.org/toc/2045-2322Abstract Space radiation consists of energetic protons and other heavier ions. During the International Space Station program, chromosome aberrations in lymphocytes of astronauts have been analyzed to estimate received biological doses of space radiation. More specifically, pre-flight blood samples were exposed ex vivo to varying doses of gamma rays, while post-flight blood samples were collected shortly and several months after landing. Here, in a study of 43 crew-missions, we investigated whether individual radiosensitivity, as determined by the ex vivo dose–response of the pre-flight chromosome aberration rate (CAR), contributes to the prediction of the post-flight CAR incurred from the radiation exposure during missions. Random-effects Poisson regression was used to estimate subject-specific radiosensitivities from the preflight dose–response data, which were in turn used to predict post-flight CAR and subject-specific relative biological effectiveness (RBEs) between space radiation and gamma radiation. Covariates age, gender were also considered. Results indicate that there is predictive value in background CAR as well as radiosensitivity determined preflight for explaining individual differences in post-flight CAR over and above that which could be explained by BFO dose alone. The in vivo RBE for space radiation was estimated to be approximately 3 relative to the ex vivo dose response to gamma irradiation. In addition, pre-flight radiosensitivity tended to be higher for individuals having a higher background CAR, suggesting that individuals with greater radiosensitivity can be more sensitive to other environmental stressors encountered in daily life. We also noted that both background CAR and radiosensitivity tend to increase with age, although both are highly variable. Finally, we observed no significant difference between the observed CAR shortly after mission and at > 6 months post-mission.Alan FeivesonKerry GeorgeMark ShaversMaria Moreno-VillanuevaYe ZhangAdriana Babiak-VazquezBrian CrucianEdward SemonesHonglu WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alan Feiveson Kerry George Mark Shavers Maria Moreno-Villanueva Ye Zhang Adriana Babiak-Vazquez Brian Crucian Edward Semones Honglu Wu Predicting chromosome damage in astronauts participating in international space station missions
description	Abstract Space radiation consists of energetic protons and other heavier ions. During the International Space Station program, chromosome aberrations in lymphocytes of astronauts have been analyzed to estimate received biological doses of space radiation. More specifically, pre-flight blood samples were exposed ex vivo to varying doses of gamma rays, while post-flight blood samples were collected shortly and several months after landing. Here, in a study of 43 crew-missions, we investigated whether individual radiosensitivity, as determined by the ex vivo dose–response of the pre-flight chromosome aberration rate (CAR), contributes to the prediction of the post-flight CAR incurred from the radiation exposure during missions. Random-effects Poisson regression was used to estimate subject-specific radiosensitivities from the preflight dose–response data, which were in turn used to predict post-flight CAR and subject-specific relative biological effectiveness (RBEs) between space radiation and gamma radiation. Covariates age, gender were also considered. Results indicate that there is predictive value in background CAR as well as radiosensitivity determined preflight for explaining individual differences in post-flight CAR over and above that which could be explained by BFO dose alone. The in vivo RBE for space radiation was estimated to be approximately 3 relative to the ex vivo dose response to gamma irradiation. In addition, pre-flight radiosensitivity tended to be higher for individuals having a higher background CAR, suggesting that individuals with greater radiosensitivity can be more sensitive to other environmental stressors encountered in daily life. We also noted that both background CAR and radiosensitivity tend to increase with age, although both are highly variable. Finally, we observed no significant difference between the observed CAR shortly after mission and at > 6 months post-mission.
format	article
author	Alan Feiveson Kerry George Mark Shavers Maria Moreno-Villanueva Ye Zhang Adriana Babiak-Vazquez Brian Crucian Edward Semones Honglu Wu
author_facet	Alan Feiveson Kerry George Mark Shavers Maria Moreno-Villanueva Ye Zhang Adriana Babiak-Vazquez Brian Crucian Edward Semones Honglu Wu
author_sort	Alan Feiveson
title	Predicting chromosome damage in astronauts participating in international space station missions
title_short	Predicting chromosome damage in astronauts participating in international space station missions
title_full	Predicting chromosome damage in astronauts participating in international space station missions
title_fullStr	Predicting chromosome damage in astronauts participating in international space station missions
title_full_unstemmed	Predicting chromosome damage in astronauts participating in international space station missions
title_sort	predicting chromosome damage in astronauts participating in international space station missions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bade7148abc2402f9e8c4d6c3b98ddad
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Predicting chromosome damage in astronauts participating in international space station missions

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