Acute Limb Ischemia in the Young: A Rare Case of Essential Thrombocytosis

Acute limb ischemia (ALI) is rarely observed in young populations. The hypercoagulable state is a notable cause of ALI other than artery disease progression and cardiac embolization. A hypercoagulable state occurs in essential thrombocytosis because of the overproduction of hematopoietic cells secon...

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Autores principales:	Johanes Nugroho, Ruth Gunadi
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/bae05b528f3c4b7895580a64408909ac
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spelling	oai:doaj.org-article:bae05b528f3c4b7895580a64408909ac2021-11-29T00:55:46ZAcute Limb Ischemia in the Young: A Rare Case of Essential Thrombocytosis2090-641210.1155/2021/2563578https://doaj.org/article/bae05b528f3c4b7895580a64408909ac2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/2563578https://doaj.org/toc/2090-6412Acute limb ischemia (ALI) is rarely observed in young populations. The hypercoagulable state is a notable cause of ALI other than artery disease progression and cardiac embolization. A hypercoagulable state occurs in essential thrombocytosis because of the overproduction of hematopoietic cells secondary to the mutation of the JAK2, CALR, or MPL genes. We report a rare case of a 37-year-old woman presenting with Rutherford IIA ALI in the left lower extremity. Laboratory data revealed she had a platelet count reaching up to 1.38 mil/μL, with other blood profiles being normal. A JAK2 mutation examination was later performed and proved positive. After careful management with catheter-directed thrombolysis, surgical thrombectomy, and cytoreductive therapy using hydroxyurea, the symptoms subsided and eventually restored the patient to physical activity in less than one month.Johanes NugrohoRuth GunadiHindawi LimitedarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENCase Reports in Cardiology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Johanes Nugroho Ruth Gunadi Acute Limb Ischemia in the Young: A Rare Case of Essential Thrombocytosis
description	Acute limb ischemia (ALI) is rarely observed in young populations. The hypercoagulable state is a notable cause of ALI other than artery disease progression and cardiac embolization. A hypercoagulable state occurs in essential thrombocytosis because of the overproduction of hematopoietic cells secondary to the mutation of the JAK2, CALR, or MPL genes. We report a rare case of a 37-year-old woman presenting with Rutherford IIA ALI in the left lower extremity. Laboratory data revealed she had a platelet count reaching up to 1.38 mil/μL, with other blood profiles being normal. A JAK2 mutation examination was later performed and proved positive. After careful management with catheter-directed thrombolysis, surgical thrombectomy, and cytoreductive therapy using hydroxyurea, the symptoms subsided and eventually restored the patient to physical activity in less than one month.
format	article
author	Johanes Nugroho Ruth Gunadi
author_facet	Johanes Nugroho Ruth Gunadi
author_sort	Johanes Nugroho
title	Acute Limb Ischemia in the Young: A Rare Case of Essential Thrombocytosis
title_short	Acute Limb Ischemia in the Young: A Rare Case of Essential Thrombocytosis
title_full	Acute Limb Ischemia in the Young: A Rare Case of Essential Thrombocytosis
title_fullStr	Acute Limb Ischemia in the Young: A Rare Case of Essential Thrombocytosis
title_full_unstemmed	Acute Limb Ischemia in the Young: A Rare Case of Essential Thrombocytosis
title_sort	acute limb ischemia in the young: a rare case of essential thrombocytosis
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/bae05b528f3c4b7895580a64408909ac
work_keys_str_mv	AT johanesnugroho acutelimbischemiaintheyoungararecaseofessentialthrombocytosis AT ruthgunadi acutelimbischemiaintheyoungararecaseofessentialthrombocytosis
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Acute Limb Ischemia in the Young: A Rare Case of Essential Thrombocytosis

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