Plasma protein expression profiles, cardiovascular disease, and religious struggles among South Asians in the MASALA study

Abstract Blood protein concentrations are clinically useful, predictive biomarkers of cardiovascular disease (CVD). Despite a higher burden of CVD among U.S. South Asians, no CVD-related proteomics study has been conducted in this sub-population. The aim of this study is to investigate the associati...

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Autores principales:	Long H. Ngo, M. Austin Argentieri, Simon T. Dillon, Blake Victor Kent, Alka M. Kanaya, Alexandra E. Shields, Towia A. Libermann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bae0f6c38d7d4bafa717a0a00d3f53ea
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spelling	oai:doaj.org-article:bae0f6c38d7d4bafa717a0a00d3f53ea2021-12-02T15:23:10ZPlasma protein expression profiles, cardiovascular disease, and religious struggles among South Asians in the MASALA study10.1038/s41598-020-79429-12045-2322https://doaj.org/article/bae0f6c38d7d4bafa717a0a00d3f53ea2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79429-1https://doaj.org/toc/2045-2322Abstract Blood protein concentrations are clinically useful, predictive biomarkers of cardiovascular disease (CVD). Despite a higher burden of CVD among U.S. South Asians, no CVD-related proteomics study has been conducted in this sub-population. The aim of this study is to investigate the associations between plasma protein levels and CVD incidence, and to assess the potential influence of religiosity/spirituality (R/S) on significant protein-CVD associations, in South Asians from the MASALA Study. We used a nested case–control design of 50 participants with incident CVD and 50 sex- and age-matched controls. Plasma samples were analyzed by SOMAscan for expression of 1305 proteins. Multivariable logistic regression models and model selection using Akaike Information Criteria were performed on the proteins and clinical covariates, with further effect modification analyses conducted to assess the influence of R/S measures on significant associations between proteins and incident CVD events. We identified 36 proteins that were significantly expressed differentially among CVD cases compared to matched controls. These proteins are involved in immune cell recruitment, atherosclerosis, endothelial cell differentiation, and vascularization. A final multivariable model found three proteins (Contactin-5 [CNTN5], Low affinity immunoglobulin gamma Fc region receptor II-a [FCGR2A], and Complement factor B [CFB]) associated with incident CVD after adjustment for diabetes (AUC = 0.82). Religious struggles that exacerbate the adverse impact of stressful life events, significantly modified the effect of Contactin-5 and Complement factor B on risk of CVD. Our research is this first assessment of the relationship between protein concentrations and risk of CVD in a South Asian sample. Further research is needed to understand patterns of proteomic profiles across diverse ethnic communities, and the influence of resources for resiliency on proteomic signatures and ultimately, risk of CVD.Long H. NgoM. Austin ArgentieriSimon T. DillonBlake Victor KentAlka M. KanayaAlexandra E. ShieldsTowia A. LibermannNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Long H. Ngo M. Austin Argentieri Simon T. Dillon Blake Victor Kent Alka M. Kanaya Alexandra E. Shields Towia A. Libermann Plasma protein expression profiles, cardiovascular disease, and religious struggles among South Asians in the MASALA study
description	Abstract Blood protein concentrations are clinically useful, predictive biomarkers of cardiovascular disease (CVD). Despite a higher burden of CVD among U.S. South Asians, no CVD-related proteomics study has been conducted in this sub-population. The aim of this study is to investigate the associations between plasma protein levels and CVD incidence, and to assess the potential influence of religiosity/spirituality (R/S) on significant protein-CVD associations, in South Asians from the MASALA Study. We used a nested case–control design of 50 participants with incident CVD and 50 sex- and age-matched controls. Plasma samples were analyzed by SOMAscan for expression of 1305 proteins. Multivariable logistic regression models and model selection using Akaike Information Criteria were performed on the proteins and clinical covariates, with further effect modification analyses conducted to assess the influence of R/S measures on significant associations between proteins and incident CVD events. We identified 36 proteins that were significantly expressed differentially among CVD cases compared to matched controls. These proteins are involved in immune cell recruitment, atherosclerosis, endothelial cell differentiation, and vascularization. A final multivariable model found three proteins (Contactin-5 [CNTN5], Low affinity immunoglobulin gamma Fc region receptor II-a [FCGR2A], and Complement factor B [CFB]) associated with incident CVD after adjustment for diabetes (AUC = 0.82). Religious struggles that exacerbate the adverse impact of stressful life events, significantly modified the effect of Contactin-5 and Complement factor B on risk of CVD. Our research is this first assessment of the relationship between protein concentrations and risk of CVD in a South Asian sample. Further research is needed to understand patterns of proteomic profiles across diverse ethnic communities, and the influence of resources for resiliency on proteomic signatures and ultimately, risk of CVD.
format	article
author	Long H. Ngo M. Austin Argentieri Simon T. Dillon Blake Victor Kent Alka M. Kanaya Alexandra E. Shields Towia A. Libermann
author_facet	Long H. Ngo M. Austin Argentieri Simon T. Dillon Blake Victor Kent Alka M. Kanaya Alexandra E. Shields Towia A. Libermann
author_sort	Long H. Ngo
title	Plasma protein expression profiles, cardiovascular disease, and religious struggles among South Asians in the MASALA study
title_short	Plasma protein expression profiles, cardiovascular disease, and religious struggles among South Asians in the MASALA study
title_full	Plasma protein expression profiles, cardiovascular disease, and religious struggles among South Asians in the MASALA study
title_fullStr	Plasma protein expression profiles, cardiovascular disease, and religious struggles among South Asians in the MASALA study
title_full_unstemmed	Plasma protein expression profiles, cardiovascular disease, and religious struggles among South Asians in the MASALA study
title_sort	plasma protein expression profiles, cardiovascular disease, and religious struggles among south asians in the masala study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bae0f6c38d7d4bafa717a0a00d3f53ea
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Plasma protein expression profiles, cardiovascular disease, and religious struggles among South Asians in the MASALA study

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