Prognostic value of programmed cell death protein 1 expression on CD8+ T lymphocytes in pancreatic cancer

Abstract Pancreatic cancer is one of the most aggressive malignancies and has a highly immunosuppressive tumour microenvironment. Immune checkpoint blockade has led to remarkable and durable objective responses in a number of malignancies and antibody-based strategies targeting programmed cell death...

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Autores principales:	Tao Shen, Liangjing Zhou, Hua Shen, Chengfei Shi, Shengnan Jia, Guo Ping Ding, Liping Cao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bae1c121b6524a89b21f7a9b00a14778
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spelling	oai:doaj.org-article:bae1c121b6524a89b21f7a9b00a147782021-12-02T15:06:01ZPrognostic value of programmed cell death protein 1 expression on CD8+ T lymphocytes in pancreatic cancer10.1038/s41598-017-08479-92045-2322https://doaj.org/article/bae1c121b6524a89b21f7a9b00a147782017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08479-9https://doaj.org/toc/2045-2322Abstract Pancreatic cancer is one of the most aggressive malignancies and has a highly immunosuppressive tumour microenvironment. Immune checkpoint blockade has led to remarkable and durable objective responses in a number of malignancies and antibody-based strategies targeting programmed cell death protein 1 (PD-1) are showing promise where traditional modalities of surgery, radiotherapy, and chemotherapy have failed. In this study, we examined the clinical value of PD-1 protein expression by CD8+ peripheral T lymphocytes or tumour-infiltrating T lymphocytes (TILs) in pancreatic ductal adenocarcinoma (PDAC). Expression of PD-1 protein on CD8+ TILs correlated with overall survival and clinicopathological characteristics such as clinical stage, N classification, and M classification. Similar findings were observed for the expression of PD-1 protein on peripheral CD8+ T cells, whereas its expression on peripheral CD4+ T cells showed no significance. Comparison of the levels of PD-1 protein expressed by peripheral CD8+ T cells before and 4 weeks after surgery indicated that preoperative and postoperative status of peripheral PD-1 expression was unchanged. Our findings showed that PD-1 protein expressed by peripheral or tumour-infiltrated CD8+ T cells was a promising biomarker for diagnosis and prognosis in PDAC and might help guide future immunotherapies.Tao ShenLiangjing ZhouHua ShenChengfei ShiShengnan JiaGuo Ping DingLiping CaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tao Shen Liangjing Zhou Hua Shen Chengfei Shi Shengnan Jia Guo Ping Ding Liping Cao Prognostic value of programmed cell death protein 1 expression on CD8+ T lymphocytes in pancreatic cancer
description	Abstract Pancreatic cancer is one of the most aggressive malignancies and has a highly immunosuppressive tumour microenvironment. Immune checkpoint blockade has led to remarkable and durable objective responses in a number of malignancies and antibody-based strategies targeting programmed cell death protein 1 (PD-1) are showing promise where traditional modalities of surgery, radiotherapy, and chemotherapy have failed. In this study, we examined the clinical value of PD-1 protein expression by CD8+ peripheral T lymphocytes or tumour-infiltrating T lymphocytes (TILs) in pancreatic ductal adenocarcinoma (PDAC). Expression of PD-1 protein on CD8+ TILs correlated with overall survival and clinicopathological characteristics such as clinical stage, N classification, and M classification. Similar findings were observed for the expression of PD-1 protein on peripheral CD8+ T cells, whereas its expression on peripheral CD4+ T cells showed no significance. Comparison of the levels of PD-1 protein expressed by peripheral CD8+ T cells before and 4 weeks after surgery indicated that preoperative and postoperative status of peripheral PD-1 expression was unchanged. Our findings showed that PD-1 protein expressed by peripheral or tumour-infiltrated CD8+ T cells was a promising biomarker for diagnosis and prognosis in PDAC and might help guide future immunotherapies.
format	article
author	Tao Shen Liangjing Zhou Hua Shen Chengfei Shi Shengnan Jia Guo Ping Ding Liping Cao
author_facet	Tao Shen Liangjing Zhou Hua Shen Chengfei Shi Shengnan Jia Guo Ping Ding Liping Cao
author_sort	Tao Shen
title	Prognostic value of programmed cell death protein 1 expression on CD8+ T lymphocytes in pancreatic cancer
title_short	Prognostic value of programmed cell death protein 1 expression on CD8+ T lymphocytes in pancreatic cancer
title_full	Prognostic value of programmed cell death protein 1 expression on CD8+ T lymphocytes in pancreatic cancer
title_fullStr	Prognostic value of programmed cell death protein 1 expression on CD8+ T lymphocytes in pancreatic cancer
title_full_unstemmed	Prognostic value of programmed cell death protein 1 expression on CD8+ T lymphocytes in pancreatic cancer
title_sort	prognostic value of programmed cell death protein 1 expression on cd8+ t lymphocytes in pancreatic cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bae1c121b6524a89b21f7a9b00a14778
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_version_	1718388667284717568

Prognostic value of programmed cell death protein 1 expression on CD8+ T lymphocytes in pancreatic cancer

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