Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling

The Snf1-related kinase (SNRK) is widely expressed and yet its function is poorly understood. Here the authors show that SNRK regulates mitochondrial coupling via the Trib3-PPARα-UCP3 pathway and that cardiac overexpression of SNRK decreases metabolic substrate usage and oxygen consumption but maint...

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Autores principales:	Amy K. Rines, Hsiang-Chun Chang, Rongxue Wu, Tatsuya Sato, Arineh Khechaduri, Hidemichi Kouzu, Jason Shapiro, Meng Shang, Michael A. Burke, Eltyeb Abdelwahid, Xinghang Jiang, Chunlei Chen, Tenley A. Rawlings, Gary D. Lopaschuk, Paul T. Schumacker, E. Dale Abel, Hossein Ardehali
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bae6e26f24c34045be0fbe2c38eff574
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spelling	oai:doaj.org-article:bae6e26f24c34045be0fbe2c38eff5742021-12-02T16:51:52ZSnf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling10.1038/ncomms140952041-1723https://doaj.org/article/bae6e26f24c34045be0fbe2c38eff5742017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14095https://doaj.org/toc/2041-1723The Snf1-related kinase (SNRK) is widely expressed and yet its function is poorly understood. Here the authors show that SNRK regulates mitochondrial coupling via the Trib3-PPARα-UCP3 pathway and that cardiac overexpression of SNRK decreases metabolic substrate usage and oxygen consumption but maintains cardiac function and energy in mice.Amy K. RinesHsiang-Chun ChangRongxue WuTatsuya SatoArineh KhechaduriHidemichi KouzuJason ShapiroMeng ShangMichael A. BurkeEltyeb AbdelwahidXinghang JiangChunlei ChenTenley A. RawlingsGary D. LopaschukPaul T. SchumackerE. Dale AbelHossein ArdehaliNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amy K. Rines Hsiang-Chun Chang Rongxue Wu Tatsuya Sato Arineh Khechaduri Hidemichi Kouzu Jason Shapiro Meng Shang Michael A. Burke Eltyeb Abdelwahid Xinghang Jiang Chunlei Chen Tenley A. Rawlings Gary D. Lopaschuk Paul T. Schumacker E. Dale Abel Hossein Ardehali Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling
description	The Snf1-related kinase (SNRK) is widely expressed and yet its function is poorly understood. Here the authors show that SNRK regulates mitochondrial coupling via the Trib3-PPARα-UCP3 pathway and that cardiac overexpression of SNRK decreases metabolic substrate usage and oxygen consumption but maintains cardiac function and energy in mice.
format	article
author	Amy K. Rines Hsiang-Chun Chang Rongxue Wu Tatsuya Sato Arineh Khechaduri Hidemichi Kouzu Jason Shapiro Meng Shang Michael A. Burke Eltyeb Abdelwahid Xinghang Jiang Chunlei Chen Tenley A. Rawlings Gary D. Lopaschuk Paul T. Schumacker E. Dale Abel Hossein Ardehali
author_facet	Amy K. Rines Hsiang-Chun Chang Rongxue Wu Tatsuya Sato Arineh Khechaduri Hidemichi Kouzu Jason Shapiro Meng Shang Michael A. Burke Eltyeb Abdelwahid Xinghang Jiang Chunlei Chen Tenley A. Rawlings Gary D. Lopaschuk Paul T. Schumacker E. Dale Abel Hossein Ardehali
author_sort	Amy K. Rines
title	Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling
title_short	Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling
title_full	Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling
title_fullStr	Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling
title_full_unstemmed	Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling
title_sort	snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bae6e26f24c34045be0fbe2c38eff574
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Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling

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