Th17 cells are involved in the local control of tumor progression in primary intraocular lymphoma.

<h4>Background</h4>Th17 cells play an important role in the pathogenesis of many autoimmune diseases, but despite some reports of their antitumor properties, too little is known about their presence and role in cancers. Specifically, knowledge is sparse about the relation of Th17 to lymp...

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Autores principales:	Claire Galand, Sabrina Donnou, Lucile Crozet, Séverine Brunet, Valérie Touitou, Hanane Ouakrim, Wolf Herman Fridman, Catherine Sautès-Fridman, Sylvain Fisson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bae849ce35b145469b530b699892ee0c
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spelling	oai:doaj.org-article:bae849ce35b145469b530b699892ee0c2021-11-04T06:08:14ZTh17 cells are involved in the local control of tumor progression in primary intraocular lymphoma.1932-620310.1371/journal.pone.0024622https://doaj.org/article/bae849ce35b145469b530b699892ee0c2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21949734/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Th17 cells play an important role in the pathogenesis of many autoimmune diseases, but despite some reports of their antitumor properties, too little is known about their presence and role in cancers. Specifically, knowledge is sparse about the relation of Th17 to lymphoma microenvironments and, more particularly, to the microenvironment of primary intraocular B-cell lymphoma (PIOL), an aggressive lymphoma with a poor prognosis.<h4>Methods and principal findings</h4>In this work, we investigated the presence of Th17 cells and their related cytokines in a syngeneic model of PIOL, a subtype of non-Hodgkin lymphoma. The very small number of lymphocytes trafficking in normal eyes, which represent a low background as compared to tumor-bearing eyes, allows us to develop the present model to characterize the different lymphocyte subsets present when a tumor is developing. IL-21 mRNA was expressed concomitantly with IL-17 mRNA in tumor-bearing eyes and intracellular expression of IL-17A and IL-21 in infiltrating CD4(+) T lymphocytes. Interestingly, IL-17A production by T cells was negatively correlated with tumor burden. We also showed that IL-21 but not IL-17 inhibits tumor cell proliferation in vitro.<h4>Conclusions</h4>These data demonstrate that IL-17A and IL-21-producing CD4(+) T cells, referred as Th17 cells, infiltrate this tumor locally and suggest that Th17-related cytokines may counteract tumor progression via IL-21 production. Thus, Th17 cells or their related cytokines could be considered to be a new therapeutic approach for non-Hodgkin B-cell lymphomas, particularly those with an ocular localization.Claire GalandSabrina DonnouLucile CrozetSéverine BrunetValérie TouitouHanane OuakrimWolf Herman FridmanCatherine Sautès-FridmanSylvain FissonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e24622 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Claire Galand Sabrina Donnou Lucile Crozet Séverine Brunet Valérie Touitou Hanane Ouakrim Wolf Herman Fridman Catherine Sautès-Fridman Sylvain Fisson Th17 cells are involved in the local control of tumor progression in primary intraocular lymphoma.
description	<h4>Background</h4>Th17 cells play an important role in the pathogenesis of many autoimmune diseases, but despite some reports of their antitumor properties, too little is known about their presence and role in cancers. Specifically, knowledge is sparse about the relation of Th17 to lymphoma microenvironments and, more particularly, to the microenvironment of primary intraocular B-cell lymphoma (PIOL), an aggressive lymphoma with a poor prognosis.<h4>Methods and principal findings</h4>In this work, we investigated the presence of Th17 cells and their related cytokines in a syngeneic model of PIOL, a subtype of non-Hodgkin lymphoma. The very small number of lymphocytes trafficking in normal eyes, which represent a low background as compared to tumor-bearing eyes, allows us to develop the present model to characterize the different lymphocyte subsets present when a tumor is developing. IL-21 mRNA was expressed concomitantly with IL-17 mRNA in tumor-bearing eyes and intracellular expression of IL-17A and IL-21 in infiltrating CD4(+) T lymphocytes. Interestingly, IL-17A production by T cells was negatively correlated with tumor burden. We also showed that IL-21 but not IL-17 inhibits tumor cell proliferation in vitro.<h4>Conclusions</h4>These data demonstrate that IL-17A and IL-21-producing CD4(+) T cells, referred as Th17 cells, infiltrate this tumor locally and suggest that Th17-related cytokines may counteract tumor progression via IL-21 production. Thus, Th17 cells or their related cytokines could be considered to be a new therapeutic approach for non-Hodgkin B-cell lymphomas, particularly those with an ocular localization.
format	article
author	Claire Galand Sabrina Donnou Lucile Crozet Séverine Brunet Valérie Touitou Hanane Ouakrim Wolf Herman Fridman Catherine Sautès-Fridman Sylvain Fisson
author_facet	Claire Galand Sabrina Donnou Lucile Crozet Séverine Brunet Valérie Touitou Hanane Ouakrim Wolf Herman Fridman Catherine Sautès-Fridman Sylvain Fisson
author_sort	Claire Galand
title	Th17 cells are involved in the local control of tumor progression in primary intraocular lymphoma.
title_short	Th17 cells are involved in the local control of tumor progression in primary intraocular lymphoma.
title_full	Th17 cells are involved in the local control of tumor progression in primary intraocular lymphoma.
title_fullStr	Th17 cells are involved in the local control of tumor progression in primary intraocular lymphoma.
title_full_unstemmed	Th17 cells are involved in the local control of tumor progression in primary intraocular lymphoma.
title_sort	th17 cells are involved in the local control of tumor progression in primary intraocular lymphoma.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/bae849ce35b145469b530b699892ee0c
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Th17 cells are involved in the local control of tumor progression in primary intraocular lymphoma.

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