Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus

The subthalamic nucleus (STN) is theorized to globally suppress movement through connections with downstream basal ganglia structures. Current theories are supported by increased STN activity when subjects withhold an uninitiated action plan, but a critical test of these theories requires studying S...

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Autores principales:	Dennis London, Arash Fazl, Kalman Katlowitz, Marisol Soula, Michael H Pourfar, Alon Y Mogilner, Roozbeh Kiani
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	subthalamic nucleus cognitive control basal ganglia systems neuroscience electrophysiology Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/bae96dd81d9e4259b12bb436b163c255
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id	oai:doaj.org-article:bae96dd81d9e4259b12bb436b163c255
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spelling	oai:doaj.org-article:bae96dd81d9e4259b12bb436b163c2552021-11-15T06:04:48ZDistinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus10.7554/eLife.648932050-084Xe64893https://doaj.org/article/bae96dd81d9e4259b12bb436b163c2552021-09-01T00:00:00Zhttps://elifesciences.org/articles/64893https://doaj.org/toc/2050-084XThe subthalamic nucleus (STN) is theorized to globally suppress movement through connections with downstream basal ganglia structures. Current theories are supported by increased STN activity when subjects withhold an uninitiated action plan, but a critical test of these theories requires studying STN responses when an ongoing action is replaced with an alternative. We perform this test in subjects with Parkinson’s disease using an extended reaching task where the movement trajectory changes mid-action. We show that STN activity decreases during action switches, contrary to prevalent theories. Furthermore, beta oscillations in the STN local field potential, which are associated with movement inhibition, do not show increased power or spiking entrainment during switches. We report an inhomogeneous population neural code in STN, with one sub-population encoding movement kinematics and direction and another encoding unexpected action switches. We suggest an elaborate neural code in STN that contributes to planning actions and changing the plans.Dennis LondonArash FazlKalman KatlowitzMarisol SoulaMichael H PourfarAlon Y MogilnerRoozbeh KianieLife Sciences Publications Ltdarticlesubthalamic nucleuscognitive controlbasal gangliasystems neuroscienceelectrophysiologyMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	subthalamic nucleus cognitive control basal ganglia systems neuroscience electrophysiology Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	subthalamic nucleus cognitive control basal ganglia systems neuroscience electrophysiology Medicine R Science Q Biology (General) QH301-705.5 Dennis London Arash Fazl Kalman Katlowitz Marisol Soula Michael H Pourfar Alon Y Mogilner Roozbeh Kiani Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus
description	The subthalamic nucleus (STN) is theorized to globally suppress movement through connections with downstream basal ganglia structures. Current theories are supported by increased STN activity when subjects withhold an uninitiated action plan, but a critical test of these theories requires studying STN responses when an ongoing action is replaced with an alternative. We perform this test in subjects with Parkinson’s disease using an extended reaching task where the movement trajectory changes mid-action. We show that STN activity decreases during action switches, contrary to prevalent theories. Furthermore, beta oscillations in the STN local field potential, which are associated with movement inhibition, do not show increased power or spiking entrainment during switches. We report an inhomogeneous population neural code in STN, with one sub-population encoding movement kinematics and direction and another encoding unexpected action switches. We suggest an elaborate neural code in STN that contributes to planning actions and changing the plans.
format	article
author	Dennis London Arash Fazl Kalman Katlowitz Marisol Soula Michael H Pourfar Alon Y Mogilner Roozbeh Kiani
author_facet	Dennis London Arash Fazl Kalman Katlowitz Marisol Soula Michael H Pourfar Alon Y Mogilner Roozbeh Kiani
author_sort	Dennis London
title	Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus
title_short	Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus
title_full	Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus
title_fullStr	Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus
title_full_unstemmed	Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus
title_sort	distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/bae96dd81d9e4259b12bb436b163c255
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Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus

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