Molecular mechanism of the MORC4 ATPase activation

Human Microrchidia 4 (MORC4) ATPase has been implicated in acute and chronic pancreatitis, inflammatory disorders and cancer. Here the authors describe the structure–function relationship of MORC4 and define the molecular mechanism for MORC4 activation.

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Autores principales:	Adam H. Tencer, Khan L. Cox, Gregory M. Wright, Yi Zhang, Christopher J. Petell, Brianna J. Klein, Brian D. Strahl, Joshua C. Black, Michael G. Poirier, Tatiana G. Kutateladze
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bae9c480125f473e8a017411be513b35
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spelling	oai:doaj.org-article:bae9c480125f473e8a017411be513b352021-12-02T17:32:12ZMolecular mechanism of the MORC4 ATPase activation10.1038/s41467-020-19278-82041-1723https://doaj.org/article/bae9c480125f473e8a017411be513b352020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19278-8https://doaj.org/toc/2041-1723Human Microrchidia 4 (MORC4) ATPase has been implicated in acute and chronic pancreatitis, inflammatory disorders and cancer. Here the authors describe the structure–function relationship of MORC4 and define the molecular mechanism for MORC4 activation.Adam H. TencerKhan L. CoxGregory M. WrightYi ZhangChristopher J. PetellBrianna J. KleinBrian D. StrahlJoshua C. BlackMichael G. PoirierTatiana G. KutateladzeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Adam H. Tencer Khan L. Cox Gregory M. Wright Yi Zhang Christopher J. Petell Brianna J. Klein Brian D. Strahl Joshua C. Black Michael G. Poirier Tatiana G. Kutateladze Molecular mechanism of the MORC4 ATPase activation
description	Human Microrchidia 4 (MORC4) ATPase has been implicated in acute and chronic pancreatitis, inflammatory disorders and cancer. Here the authors describe the structure–function relationship of MORC4 and define the molecular mechanism for MORC4 activation.
format	article
author	Adam H. Tencer Khan L. Cox Gregory M. Wright Yi Zhang Christopher J. Petell Brianna J. Klein Brian D. Strahl Joshua C. Black Michael G. Poirier Tatiana G. Kutateladze
author_facet	Adam H. Tencer Khan L. Cox Gregory M. Wright Yi Zhang Christopher J. Petell Brianna J. Klein Brian D. Strahl Joshua C. Black Michael G. Poirier Tatiana G. Kutateladze
author_sort	Adam H. Tencer
title	Molecular mechanism of the MORC4 ATPase activation
title_short	Molecular mechanism of the MORC4 ATPase activation
title_full	Molecular mechanism of the MORC4 ATPase activation
title_fullStr	Molecular mechanism of the MORC4 ATPase activation
title_full_unstemmed	Molecular mechanism of the MORC4 ATPase activation
title_sort	molecular mechanism of the morc4 atpase activation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bae9c480125f473e8a017411be513b35
work_keys_str_mv	AT adamhtencer molecularmechanismofthemorc4atpaseactivation AT khanlcox molecularmechanismofthemorc4atpaseactivation AT gregorymwright molecularmechanismofthemorc4atpaseactivation AT yizhang molecularmechanismofthemorc4atpaseactivation AT christopherjpetell molecularmechanismofthemorc4atpaseactivation AT briannajklein molecularmechanismofthemorc4atpaseactivation AT briandstrahl molecularmechanismofthemorc4atpaseactivation AT joshuacblack molecularmechanismofthemorc4atpaseactivation AT michaelgpoirier molecularmechanismofthemorc4atpaseactivation AT tatianagkutateladze molecularmechanismofthemorc4atpaseactivation
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Molecular mechanism of the MORC4 ATPase activation

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