Gene-expression signatures can distinguish gastric cancer grades and stages.

Microarray gene-expression data of 54 paired gastric cancer and adjacent noncancerous gastric tissues were analyzed, with the aim to establish gene signatures for cancer grades (well-, moderately-, poorly- or un-differentiated) and stages (I, II, III and IV), which have been determined by pathologis...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Juan Cui, Fan Li, Guoqing Wang, Xuedong Fang, J David Puett, Ying Xu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/baed0e50502e42d6ba9dce899f9c5dc1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:baed0e50502e42d6ba9dce899f9c5dc1
record_format	dspace
spelling	oai:doaj.org-article:baed0e50502e42d6ba9dce899f9c5dc12021-11-18T06:57:06ZGene-expression signatures can distinguish gastric cancer grades and stages.1932-620310.1371/journal.pone.0017819https://doaj.org/article/baed0e50502e42d6ba9dce899f9c5dc12011-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21445269/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Microarray gene-expression data of 54 paired gastric cancer and adjacent noncancerous gastric tissues were analyzed, with the aim to establish gene signatures for cancer grades (well-, moderately-, poorly- or un-differentiated) and stages (I, II, III and IV), which have been determined by pathologists. Our statistical analysis led to the identification of a number of gene combinations whose expression patterns serve well as signatures of different grades and different stages of gastric cancer. A 19-gene signature was found to have discerning power between high- and low-grade gastric cancers in general, with overall classification accuracy at 79.6%. An expanded 198-gene panel allows the stratification of cancers into four grades and control, giving rise to an overall classification agreement of 74.2% between each grade designated by the pathologists and our prediction. Two signatures for cancer staging, consisting of 10 genes and 9 genes, respectively, provide high classification accuracies at 90.0% and 84.0%, among early-, advanced-stage cancer and control. Functional and pathway analyses on these signature genes reveal the significant relevance of the derived signatures to cancer grades and progression. To the best of our knowledge, this represents the first study on identification of genes whose expression patterns can serve as markers for cancer grades and stages.Juan CuiFan LiGuoqing WangXuedong FangJ David PuettYing XuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 3, p e17819 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juan Cui Fan Li Guoqing Wang Xuedong Fang J David Puett Ying Xu Gene-expression signatures can distinguish gastric cancer grades and stages.
description	Microarray gene-expression data of 54 paired gastric cancer and adjacent noncancerous gastric tissues were analyzed, with the aim to establish gene signatures for cancer grades (well-, moderately-, poorly- or un-differentiated) and stages (I, II, III and IV), which have been determined by pathologists. Our statistical analysis led to the identification of a number of gene combinations whose expression patterns serve well as signatures of different grades and different stages of gastric cancer. A 19-gene signature was found to have discerning power between high- and low-grade gastric cancers in general, with overall classification accuracy at 79.6%. An expanded 198-gene panel allows the stratification of cancers into four grades and control, giving rise to an overall classification agreement of 74.2% between each grade designated by the pathologists and our prediction. Two signatures for cancer staging, consisting of 10 genes and 9 genes, respectively, provide high classification accuracies at 90.0% and 84.0%, among early-, advanced-stage cancer and control. Functional and pathway analyses on these signature genes reveal the significant relevance of the derived signatures to cancer grades and progression. To the best of our knowledge, this represents the first study on identification of genes whose expression patterns can serve as markers for cancer grades and stages.
format	article
author	Juan Cui Fan Li Guoqing Wang Xuedong Fang J David Puett Ying Xu
author_facet	Juan Cui Fan Li Guoqing Wang Xuedong Fang J David Puett Ying Xu
author_sort	Juan Cui
title	Gene-expression signatures can distinguish gastric cancer grades and stages.
title_short	Gene-expression signatures can distinguish gastric cancer grades and stages.
title_full	Gene-expression signatures can distinguish gastric cancer grades and stages.
title_fullStr	Gene-expression signatures can distinguish gastric cancer grades and stages.
title_full_unstemmed	Gene-expression signatures can distinguish gastric cancer grades and stages.
title_sort	gene-expression signatures can distinguish gastric cancer grades and stages.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/baed0e50502e42d6ba9dce899f9c5dc1
work_keys_str_mv	AT juancui geneexpressionsignaturescandistinguishgastriccancergradesandstages AT fanli geneexpressionsignaturescandistinguishgastriccancergradesandstages AT guoqingwang geneexpressionsignaturescandistinguishgastriccancergradesandstages AT xuedongfang geneexpressionsignaturescandistinguishgastriccancergradesandstages AT jdavidpuett geneexpressionsignaturescandistinguishgastriccancergradesandstages AT yingxu geneexpressionsignaturescandistinguishgastriccancergradesandstages
_version_	1718424190386700288

Gene-expression signatures can distinguish gastric cancer grades and stages.

Ejemplares similares