Predictors of Mortality Among Adult HIV-Infected Patients Taking Antiretroviral Therapy (ART) in Harari Hospitals, Ethiopia

Abdi Birhanu,1 Tariku Dingeta,2 Moti Tolera2 1School of Medicine, College of Health and Medical Science, Haramaya University, Harar, Ethiopia; 2School of Public Health, College of Health and Medical Science, Haramaya University, Harar, EthiopiaCorrespondence: Abdi BirhanuSchool of Medicine, College...

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Autores principales:	Birhanu A, Dingeta T, Tolera M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	predictors mortality hiv art adult ethiopia. Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/baeded3e43c9423a98a11dcfdbb8d701
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spelling	oai:doaj.org-article:baeded3e43c9423a98a11dcfdbb8d7012021-12-02T16:32:14ZPredictors of Mortality Among Adult HIV-Infected Patients Taking Antiretroviral Therapy (ART) in Harari Hospitals, Ethiopia1179-1373https://doaj.org/article/baeded3e43c9423a98a11dcfdbb8d7012021-07-01T00:00:00Zhttps://www.dovepress.com/predictors-of-mortality-among-adult-hiv-infected-patients-taking-antir-peer-reviewed-fulltext-article-HIVhttps://doaj.org/toc/1179-1373Abdi Birhanu,1 Tariku Dingeta,2 Moti Tolera2 1School of Medicine, College of Health and Medical Science, Haramaya University, Harar, Ethiopia; 2School of Public Health, College of Health and Medical Science, Haramaya University, Harar, EthiopiaCorrespondence: Abdi BirhanuSchool of Medicine, College of Health and Medical Science, Haramaya University, PO Box: 235, Harar, EthiopiaTel +251917094058Email abdiibiree@gmail.comIntroduction: Despite the world has made efforts, the reduction of acquired immunodeficiency syndrome (AIDS) related mortality by giving antiretroviral therapy (ART), still HIV/AIDS is killing people while they are on ART. However, the current progress and associated factors of mortality among ART-taking patients are hardly available. Therefore, this study was aimed to determine predictors of mortality among HIV-infected adult patients after starting antiretroviral therapy in Harar Hospitals, Harari region, Ethiopia.Methods: A facility-based retrospective cohort study was employed with randomly selected 610 medical records of HIV patients on antiretroviral therapy (ART). Adjusted hazard ratio (AHR) with 95% confidence interval (CI) was used to identify predictors of mortality using multivariate Cox proportional hazard model.Results: Among 610 medical records analyzed with a total of 1410.7 follow-up years, 67 (11%) deaths were found giving an overall mortality rate of 4.75 per 100 person-years. The independent predictor of mortality identified was ambulatory/bedridden functional status (AHR=2.48; 95% CI: 1.43– 4.28), taking other than Tenofovir-based regimen (AHR=2.5,95% CI; 1.04– 5.94), not taking isoniazid preventive therapy (IPT) (AHR=2.8; 95% CI: 1.61,4.71), hemoglobin < 11g/dl (AHR=3.33,95% CI 1.94– 5.69), and poor adherence to ART (AHR= 3.62, 95% CI: 1.87– 7.0).Conclusion: This study demonstrated that poor ART adherence, not taking IPT, and initiating ART with a non-Tenofovir-based regimen and low hemoglobin count were significantly associated with the risk of death. For this reason, addressing these all significant predictors is essential to prevent early death.Keywords: predictors, mortality, HIV, ART, adult, EthiopiaBirhanu ADingeta TTolera MDove Medical Pressarticlepredictorsmortalityhivartadultethiopia.Immunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 13, Pp 727-736 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	predictors mortality hiv art adult ethiopia. Immunologic diseases. Allergy RC581-607
spellingShingle	predictors mortality hiv art adult ethiopia. Immunologic diseases. Allergy RC581-607 Birhanu A Dingeta T Tolera M Predictors of Mortality Among Adult HIV-Infected Patients Taking Antiretroviral Therapy (ART) in Harari Hospitals, Ethiopia
description	Abdi Birhanu,1 Tariku Dingeta,2 Moti Tolera2 1School of Medicine, College of Health and Medical Science, Haramaya University, Harar, Ethiopia; 2School of Public Health, College of Health and Medical Science, Haramaya University, Harar, EthiopiaCorrespondence: Abdi BirhanuSchool of Medicine, College of Health and Medical Science, Haramaya University, PO Box: 235, Harar, EthiopiaTel +251917094058Email abdiibiree@gmail.comIntroduction: Despite the world has made efforts, the reduction of acquired immunodeficiency syndrome (AIDS) related mortality by giving antiretroviral therapy (ART), still HIV/AIDS is killing people while they are on ART. However, the current progress and associated factors of mortality among ART-taking patients are hardly available. Therefore, this study was aimed to determine predictors of mortality among HIV-infected adult patients after starting antiretroviral therapy in Harar Hospitals, Harari region, Ethiopia.Methods: A facility-based retrospective cohort study was employed with randomly selected 610 medical records of HIV patients on antiretroviral therapy (ART). Adjusted hazard ratio (AHR) with 95% confidence interval (CI) was used to identify predictors of mortality using multivariate Cox proportional hazard model.Results: Among 610 medical records analyzed with a total of 1410.7 follow-up years, 67 (11%) deaths were found giving an overall mortality rate of 4.75 per 100 person-years. The independent predictor of mortality identified was ambulatory/bedridden functional status (AHR=2.48; 95% CI: 1.43– 4.28), taking other than Tenofovir-based regimen (AHR=2.5,95% CI; 1.04– 5.94), not taking isoniazid preventive therapy (IPT) (AHR=2.8; 95% CI: 1.61,4.71), hemoglobin < 11g/dl (AHR=3.33,95% CI 1.94– 5.69), and poor adherence to ART (AHR= 3.62, 95% CI: 1.87– 7.0).Conclusion: This study demonstrated that poor ART adherence, not taking IPT, and initiating ART with a non-Tenofovir-based regimen and low hemoglobin count were significantly associated with the risk of death. For this reason, addressing these all significant predictors is essential to prevent early death.Keywords: predictors, mortality, HIV, ART, adult, Ethiopia
format	article
author	Birhanu A Dingeta T Tolera M
author_facet	Birhanu A Dingeta T Tolera M
author_sort	Birhanu A
title	Predictors of Mortality Among Adult HIV-Infected Patients Taking Antiretroviral Therapy (ART) in Harari Hospitals, Ethiopia
title_short	Predictors of Mortality Among Adult HIV-Infected Patients Taking Antiretroviral Therapy (ART) in Harari Hospitals, Ethiopia
title_full	Predictors of Mortality Among Adult HIV-Infected Patients Taking Antiretroviral Therapy (ART) in Harari Hospitals, Ethiopia
title_fullStr	Predictors of Mortality Among Adult HIV-Infected Patients Taking Antiretroviral Therapy (ART) in Harari Hospitals, Ethiopia
title_full_unstemmed	Predictors of Mortality Among Adult HIV-Infected Patients Taking Antiretroviral Therapy (ART) in Harari Hospitals, Ethiopia
title_sort	predictors of mortality among adult hiv-infected patients taking antiretroviral therapy (art) in harari hospitals, ethiopia
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/baeded3e43c9423a98a11dcfdbb8d701
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Predictors of Mortality Among Adult HIV-Infected Patients Taking Antiretroviral Therapy (ART) in Harari Hospitals, Ethiopia

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