Enhancement of radiotherapy by ceria nanoparticles modified with neogambogic acid in breast cancer cells

Feng Chen,1 Xiao Hong Zhang,1 Xiao Dan Hu,1 Wei Zhang,1 Zhi Chao Lou,1 Li Hua Xie,1 Pei Dang Liu,2 Hai Qian Zhang1,21College of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, 2Jiangsu Laboratory for Biomaterials and Devices, Southeast University, Nanjing, Peopl...

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Autores principales:	Chen F, Zhang XH, Hu XD, Zhang W, Lou ZC, Xie LH, Liu PD, Zhang HQ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/baee10f302354e1cafd26d380a192a43
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spelling	oai:doaj.org-article:baee10f302354e1cafd26d380a192a432021-12-02T02:10:30ZEnhancement of radiotherapy by ceria nanoparticles modified with neogambogic acid in breast cancer cells1178-2013https://doaj.org/article/baee10f302354e1cafd26d380a192a432015-08-01T00:00:00Zhttp://www.dovepress.com/enhancement-of-radiotherapy-by-ceria-nanoparticles-modified-with-neoga-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Feng Chen,1 Xiao Hong Zhang,1 Xiao Dan Hu,1 Wei Zhang,1 Zhi Chao Lou,1 Li Hua Xie,1 Pei Dang Liu,2 Hai Qian Zhang1,21College of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, 2Jiangsu Laboratory for Biomaterials and Devices, Southeast University, Nanjing, People’s Republic of ChinaAbstract: Radiotherapy is one of the main strategies for cancer treatment but has significant challenges, such as cancer cell resistance and radiation damage to normal tissue. Radiosensitizers that selectively increase the susceptibility of cancer cells to radiation can enhance the effectiveness of radiotherapy. We report here the development of a novel radiosensitizer consisting of monodispersed ceria nanoparticles (CNPs) covered with the anticancer drug neogambogic acid (NGA-CNPs). These were used in conjunction with radiation in MCF-7 breast cancer cells, and the efficacy and mechanisms of action of this combined treatment approach were evaluated. NGA-CNPs potentiated the toxic effects of radiation, leading to a higher rate of cell death than either treatment used alone and inducing the activation of autophagy and cell cycle arrest at the G2/M phase, while pretreatment with NGA or CNPs did not improve the rate of radiation-induced cancer cells death. However, NGA-CNPs decreased both endogenous and radiation-induced reactive oxygen species formation, unlike other nanomaterials. These results suggest that the adjunctive use of NGA-CNPs can increase the effectiveness of radiotherapy in breast cancer treatment by lowering the radiation doses required to kill cancer cells and thereby minimizing collateral damage to healthy adjacent tissue.Keywords: ceria nanoparticles, radiotherapy, breast cancer cells, neogambogic acid, radiosensitizationChen FZhang XHHu XDZhang WLou ZCXie LHLiu PDZhang HQDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 4957-4969 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Chen F Zhang XH Hu XD Zhang W Lou ZC Xie LH Liu PD Zhang HQ Enhancement of radiotherapy by ceria nanoparticles modified with neogambogic acid in breast cancer cells
description	Feng Chen,1 Xiao Hong Zhang,1 Xiao Dan Hu,1 Wei Zhang,1 Zhi Chao Lou,1 Li Hua Xie,1 Pei Dang Liu,2 Hai Qian Zhang1,21College of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, 2Jiangsu Laboratory for Biomaterials and Devices, Southeast University, Nanjing, People’s Republic of ChinaAbstract: Radiotherapy is one of the main strategies for cancer treatment but has significant challenges, such as cancer cell resistance and radiation damage to normal tissue. Radiosensitizers that selectively increase the susceptibility of cancer cells to radiation can enhance the effectiveness of radiotherapy. We report here the development of a novel radiosensitizer consisting of monodispersed ceria nanoparticles (CNPs) covered with the anticancer drug neogambogic acid (NGA-CNPs). These were used in conjunction with radiation in MCF-7 breast cancer cells, and the efficacy and mechanisms of action of this combined treatment approach were evaluated. NGA-CNPs potentiated the toxic effects of radiation, leading to a higher rate of cell death than either treatment used alone and inducing the activation of autophagy and cell cycle arrest at the G2/M phase, while pretreatment with NGA or CNPs did not improve the rate of radiation-induced cancer cells death. However, NGA-CNPs decreased both endogenous and radiation-induced reactive oxygen species formation, unlike other nanomaterials. These results suggest that the adjunctive use of NGA-CNPs can increase the effectiveness of radiotherapy in breast cancer treatment by lowering the radiation doses required to kill cancer cells and thereby minimizing collateral damage to healthy adjacent tissue.Keywords: ceria nanoparticles, radiotherapy, breast cancer cells, neogambogic acid, radiosensitization
format	article
author	Chen F Zhang XH Hu XD Zhang W Lou ZC Xie LH Liu PD Zhang HQ
author_facet	Chen F Zhang XH Hu XD Zhang W Lou ZC Xie LH Liu PD Zhang HQ
author_sort	Chen F
title	Enhancement of radiotherapy by ceria nanoparticles modified with neogambogic acid in breast cancer cells
title_short	Enhancement of radiotherapy by ceria nanoparticles modified with neogambogic acid in breast cancer cells
title_full	Enhancement of radiotherapy by ceria nanoparticles modified with neogambogic acid in breast cancer cells
title_fullStr	Enhancement of radiotherapy by ceria nanoparticles modified with neogambogic acid in breast cancer cells
title_full_unstemmed	Enhancement of radiotherapy by ceria nanoparticles modified with neogambogic acid in breast cancer cells
title_sort	enhancement of radiotherapy by ceria nanoparticles modified with neogambogic acid in breast cancer cells
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/baee10f302354e1cafd26d380a192a43
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Enhancement of radiotherapy by ceria nanoparticles modified with neogambogic acid in&nbsp;breast cancer cells

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Enhancement of radiotherapy by ceria nanoparticles modified with neogambogic acid in breast cancer cells