Multiple Antitumor Molecular Mechanisms Are Activated by a Fully Synthetic and Stabilized Pharmaceutical Product Delivering the Active Compound Sulforaphane (SFX-01) in Preclinical Model of Human Glioblastoma

Multiple Antitumor Molecular Mechanisms Are Activated by a Fully Synthetic and Stabilized Pharmaceutical Product Delivering the Active Compound Sulforaphane (SFX-01) in Preclinical Model of Human Glioblastoma

Frequent relapses and therapeutic resistance make the management of glioblastoma (GBM, grade IV glioma), extremely difficult. Therefore, it is necessary to develop new pharmacological compounds to be used as a single treatment or in combination with current therapies in order to improve their effect...

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Bibliographic Details
Main Authors: Alessandro Colapietro, Alessandra Rossetti, Andrea Mancini, Stefano Martellucci, Giuseppe Ocone, Fanny Pulcini, Leda Biordi, Loredana Cristiano, Vincenzo Mattei, Simona Delle Monache, Francesco Marampon, Giovanni Luca Gravina, Claudio Festuccia
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
GBM
sulforaphane
SFX-01
hypoxia
epithelial-to-mesenchymal trans-differentiation (EMT)
stemness and tumor recurrence
Medicine
R
Pharmacy and materia medica
RS1-441
Online Access:https://doaj.org/article/baf03a3f94c84c318f59603f59efb87f
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