Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer

Gastric cancer (GC) is one of the most prevalent malignant tumor types and the third leading cause of cancer-related death worldwide. Its morbidity and mortality are very high due to a lack of understanding about its pathogenesis and the slow development of novel therapeutic strategies. Long non-cod...

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Autores principales:	Ying Liu, Wei Ding, Wanpeng Yu, Yuan Zhang, Xiang Ao, Jianxun Wang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	long non-coding RNA biogenesis biomarker therapeutic target gastric cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/baf485ed79e3427993caa837fae009f2
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spelling	oai:doaj.org-article:baf485ed79e3427993caa837fae009f22021-11-26T04:35:17ZLong non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer2372-770510.1016/j.omto.2021.11.005https://doaj.org/article/baf485ed79e3427993caa837fae009f22021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2372770521001546https://doaj.org/toc/2372-7705Gastric cancer (GC) is one of the most prevalent malignant tumor types and the third leading cause of cancer-related death worldwide. Its morbidity and mortality are very high due to a lack of understanding about its pathogenesis and the slow development of novel therapeutic strategies. Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs with a length of more than 200 nt. They play crucial roles in a wide spectrum of physiological and pathological processes by regulating the expression of genes involved in proliferation, differentiation, apoptosis, cell cycle, invasion, metastasis, DNA damage, and carcinogenesis. The aberrant expression of lncRNAs has been found in various cancer types. A growing amount of evidence demonstrates that lncRNAs are involved in many aspects of GC pathogenesis, including its occurrence, metastasis, and recurrence, indicating their potential role as novel biomarkers in the diagnosis, prognosis, and therapeutic targets of GC. This review systematically summarizes the biogenesis, biological properties, and functions of lncRNAs and highlights their critical role and clinical significance in GC. This information may contribute to the development of better diagnostics and treatments for GC.Ying LiuWei DingWanpeng YuYuan ZhangXiang AoJianxun WangElsevierarticlelong non-coding RNAbiogenesisbiomarkertherapeutic targetgastric cancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENMolecular Therapy: Oncolytics, Vol 23, Iss , Pp 458-476 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	long non-coding RNA biogenesis biomarker therapeutic target gastric cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	long non-coding RNA biogenesis biomarker therapeutic target gastric cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ying Liu Wei Ding Wanpeng Yu Yuan Zhang Xiang Ao Jianxun Wang Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer
description	Gastric cancer (GC) is one of the most prevalent malignant tumor types and the third leading cause of cancer-related death worldwide. Its morbidity and mortality are very high due to a lack of understanding about its pathogenesis and the slow development of novel therapeutic strategies. Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs with a length of more than 200 nt. They play crucial roles in a wide spectrum of physiological and pathological processes by regulating the expression of genes involved in proliferation, differentiation, apoptosis, cell cycle, invasion, metastasis, DNA damage, and carcinogenesis. The aberrant expression of lncRNAs has been found in various cancer types. A growing amount of evidence demonstrates that lncRNAs are involved in many aspects of GC pathogenesis, including its occurrence, metastasis, and recurrence, indicating their potential role as novel biomarkers in the diagnosis, prognosis, and therapeutic targets of GC. This review systematically summarizes the biogenesis, biological properties, and functions of lncRNAs and highlights their critical role and clinical significance in GC. This information may contribute to the development of better diagnostics and treatments for GC.
format	article
author	Ying Liu Wei Ding Wanpeng Yu Yuan Zhang Xiang Ao Jianxun Wang
author_facet	Ying Liu Wei Ding Wanpeng Yu Yuan Zhang Xiang Ao Jianxun Wang
author_sort	Ying Liu
title	Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer
title_short	Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer
title_full	Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer
title_fullStr	Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer
title_full_unstemmed	Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer
title_sort	long non-coding rnas: biogenesis, functions, and clinical significance in gastric cancer
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/baf485ed79e3427993caa837fae009f2
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Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer

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