Molecular Profile Study of Extracellular Vesicles for the Identification of Useful Small “Hit” in Cancer Diagnosis

Tumor-secreted extracellular vesicles (EVs) are the main mediators of cell-cell communication, permitting cells to exchange proteins, lipids, and metabolites in varying physiological and pathological conditions. They contain signature tumor-derived molecules that reflect the intracellular status of...

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Autores principales:	Giusi Alberti, Christian M. Sánchez-López, Alexia Andres, Radha Santonocito, Claudia Campanella, Francesco Cappello, Antonio Marcilla
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	extracellular vesicles liquid biopsy biomarkers tumor progression metastasis Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/bafabed227544fdabe6b2a675e57ecf6
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spelling	oai:doaj.org-article:bafabed227544fdabe6b2a675e57ecf62021-11-25T16:38:09ZMolecular Profile Study of Extracellular Vesicles for the Identification of Useful Small “Hit” in Cancer Diagnosis10.3390/app1122107872076-3417https://doaj.org/article/bafabed227544fdabe6b2a675e57ecf62021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/22/10787https://doaj.org/toc/2076-3417Tumor-secreted extracellular vesicles (EVs) are the main mediators of cell-cell communication, permitting cells to exchange proteins, lipids, and metabolites in varying physiological and pathological conditions. They contain signature tumor-derived molecules that reflect the intracellular status of their cell of origin. Recent studies have shown that tumor cell-derived EVs can aid in cancer metastasis through the modulation of the tumor microenvironment, suppression of the immune system, pre-metastatic niche formation, and subsequent metastasis. EVs can easily be isolated from a variety of biological fluids, and their content makes them useful biomarkers for the diagnosis, prognosis, monitorization of cancer progression, and response to treatment. This review aims to explore the biomarkers of cancer cell-derived EVs obtained from liquid biopsies, in order to understand cancer progression and metastatic evolution for early diagnosis and precision therapy.Giusi AlbertiChristian M. Sánchez-LópezAlexia AndresRadha SantonocitoClaudia CampanellaFrancesco CappelloAntonio MarcillaMDPI AGarticleextracellular vesiclesliquid biopsybiomarkerstumor progressionmetastasisTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10787, p 10787 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	extracellular vesicles liquid biopsy biomarkers tumor progression metastasis Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	extracellular vesicles liquid biopsy biomarkers tumor progression metastasis Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Giusi Alberti Christian M. Sánchez-López Alexia Andres Radha Santonocito Claudia Campanella Francesco Cappello Antonio Marcilla Molecular Profile Study of Extracellular Vesicles for the Identification of Useful Small “Hit” in Cancer Diagnosis
description	Tumor-secreted extracellular vesicles (EVs) are the main mediators of cell-cell communication, permitting cells to exchange proteins, lipids, and metabolites in varying physiological and pathological conditions. They contain signature tumor-derived molecules that reflect the intracellular status of their cell of origin. Recent studies have shown that tumor cell-derived EVs can aid in cancer metastasis through the modulation of the tumor microenvironment, suppression of the immune system, pre-metastatic niche formation, and subsequent metastasis. EVs can easily be isolated from a variety of biological fluids, and their content makes them useful biomarkers for the diagnosis, prognosis, monitorization of cancer progression, and response to treatment. This review aims to explore the biomarkers of cancer cell-derived EVs obtained from liquid biopsies, in order to understand cancer progression and metastatic evolution for early diagnosis and precision therapy.
format	article
author	Giusi Alberti Christian M. Sánchez-López Alexia Andres Radha Santonocito Claudia Campanella Francesco Cappello Antonio Marcilla
author_facet	Giusi Alberti Christian M. Sánchez-López Alexia Andres Radha Santonocito Claudia Campanella Francesco Cappello Antonio Marcilla
author_sort	Giusi Alberti
title	Molecular Profile Study of Extracellular Vesicles for the Identification of Useful Small “Hit” in Cancer Diagnosis
title_short	Molecular Profile Study of Extracellular Vesicles for the Identification of Useful Small “Hit” in Cancer Diagnosis
title_full	Molecular Profile Study of Extracellular Vesicles for the Identification of Useful Small “Hit” in Cancer Diagnosis
title_fullStr	Molecular Profile Study of Extracellular Vesicles for the Identification of Useful Small “Hit” in Cancer Diagnosis
title_full_unstemmed	Molecular Profile Study of Extracellular Vesicles for the Identification of Useful Small “Hit” in Cancer Diagnosis
title_sort	molecular profile study of extracellular vesicles for the identification of useful small “hit” in cancer diagnosis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bafabed227544fdabe6b2a675e57ecf6
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Molecular Profile Study of Extracellular Vesicles for the Identification of Useful Small “Hit” in Cancer Diagnosis

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