Anomalous X-ray diffraction studies of ion transport in K+ channels

The number of K+ occupied binding sites in the selectivity filter of potassium ion channels is still under debate. Here, the authors collect diffraction data on the K+ selective NaK channel NaK2K at a wavelength of 3.35 Å, close to the K absorption edge, revealing that all four binding sites in the...

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Autores principales: Patricia S. Langan, Venu Gopal Vandavasi, Kevin L. Weiss, Pavel V. Afonine, Kamel el Omari, Ramona Duman, Armin Wagner, Leighton Coates
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/bafe95be81dc4ff48f38b4eebc576346
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Sumario:The number of K+ occupied binding sites in the selectivity filter of potassium ion channels is still under debate. Here, the authors collect diffraction data on the K+ selective NaK channel NaK2K at a wavelength of 3.35 Å, close to the K absorption edge, revealing that all four binding sites in the selectivity filter are fully occupied by K+ ions.