A site of vulnerability at V3 crown defined by HIV-1 bNAb M4008_N1

Mapping of the HIV Env surface epitopes targeted by broadly neutralizing antibodies (bNAbs) is of great interest for HIV-1 vaccine design. Here, the authors present the 3.2 Å cryo-EM structure of the bNAb M4008_N1 in complex with BG505 DS-SOSIP, an engineered native-like Env trimer and observe that...

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Autores principales:	Kun-Wei Chan, Christina C. Luo, Hong Lu, Xueling Wu, Xiang-Peng Kong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bb01949e422e42d6906fec7ea24e7540
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spelling	oai:doaj.org-article:bb01949e422e42d6906fec7ea24e75402021-11-14T12:34:22ZA site of vulnerability at V3 crown defined by HIV-1 bNAb M4008_N110.1038/s41467-021-26846-z2041-1723https://doaj.org/article/bb01949e422e42d6906fec7ea24e75402021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26846-zhttps://doaj.org/toc/2041-1723Mapping of the HIV Env surface epitopes targeted by broadly neutralizing antibodies (bNAbs) is of great interest for HIV-1 vaccine design. Here, the authors present the 3.2 Å cryo-EM structure of the bNAb M4008_N1 in complex with BG505 DS-SOSIP, an engineered native-like Env trimer and observe that the bNAb epitope is centered at the V3 crown and that M4008_N1 uses its CDR H3 to form an extended β-sheet with the β-hairpin of the V3 crown in a conformation stabilized in the prefusion trimer.Kun-Wei ChanChristina C. LuoHong LuXueling WuXiang-Peng KongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kun-Wei Chan Christina C. Luo Hong Lu Xueling Wu Xiang-Peng Kong A site of vulnerability at V3 crown defined by HIV-1 bNAb M4008_N1
description	Mapping of the HIV Env surface epitopes targeted by broadly neutralizing antibodies (bNAbs) is of great interest for HIV-1 vaccine design. Here, the authors present the 3.2 Å cryo-EM structure of the bNAb M4008_N1 in complex with BG505 DS-SOSIP, an engineered native-like Env trimer and observe that the bNAb epitope is centered at the V3 crown and that M4008_N1 uses its CDR H3 to form an extended β-sheet with the β-hairpin of the V3 crown in a conformation stabilized in the prefusion trimer.
format	article
author	Kun-Wei Chan Christina C. Luo Hong Lu Xueling Wu Xiang-Peng Kong
author_facet	Kun-Wei Chan Christina C. Luo Hong Lu Xueling Wu Xiang-Peng Kong
author_sort	Kun-Wei Chan
title	A site of vulnerability at V3 crown defined by HIV-1 bNAb M4008_N1
title_short	A site of vulnerability at V3 crown defined by HIV-1 bNAb M4008_N1
title_full	A site of vulnerability at V3 crown defined by HIV-1 bNAb M4008_N1
title_fullStr	A site of vulnerability at V3 crown defined by HIV-1 bNAb M4008_N1
title_full_unstemmed	A site of vulnerability at V3 crown defined by HIV-1 bNAb M4008_N1
title_sort	site of vulnerability at v3 crown defined by hiv-1 bnab m4008_n1
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bb01949e422e42d6906fec7ea24e7540
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A site of vulnerability at V3 crown defined by HIV-1 bNAb M4008_N1

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