RSPO3 is important for trabecular bone and fracture risk in mice and humans
Genetic association signals for fractures have been reported at the RSPO3 locus, but the causal gene and the underlying mechanism are unknown. Here, the authors show that RSPO3 exerts an important role for vertebral trabecular bone mass and bone strength in mice and fracture risk in humans.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/bb0475854da041a2990d5eeb48bf5cee |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:bb0475854da041a2990d5eeb48bf5cee |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:bb0475854da041a2990d5eeb48bf5cee2021-12-02T19:06:43ZRSPO3 is important for trabecular bone and fracture risk in mice and humans10.1038/s41467-021-25124-22041-1723https://doaj.org/article/bb0475854da041a2990d5eeb48bf5cee2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25124-2https://doaj.org/toc/2041-1723Genetic association signals for fractures have been reported at the RSPO3 locus, but the causal gene and the underlying mechanism are unknown. Here, the authors show that RSPO3 exerts an important role for vertebral trabecular bone mass and bone strength in mice and fracture risk in humans.Karin H. NilssonPetra HenningMaha El ShahawyMaria NethanderThomas Levin AndersenCharlotte EjerstedJianyao WuKarin L. GustafssonAntti KoskelaJuha TuukkanenPedro P. C. SouzaJan TuckermannMattias LorentzonLinda Engström RuudTerho LehtimäkiJon H. TobiasSirui ZhouUlf H. LernerJ. Brent RichardsSofia Movérare-SkrticClaes OhlssonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Karin H. Nilsson Petra Henning Maha El Shahawy Maria Nethander Thomas Levin Andersen Charlotte Ejersted Jianyao Wu Karin L. Gustafsson Antti Koskela Juha Tuukkanen Pedro P. C. Souza Jan Tuckermann Mattias Lorentzon Linda Engström Ruud Terho Lehtimäki Jon H. Tobias Sirui Zhou Ulf H. Lerner J. Brent Richards Sofia Movérare-Skrtic Claes Ohlsson RSPO3 is important for trabecular bone and fracture risk in mice and humans |
| description |
Genetic association signals for fractures have been reported at the RSPO3 locus, but the causal gene and the underlying mechanism are unknown. Here, the authors show that RSPO3 exerts an important role for vertebral trabecular bone mass and bone strength in mice and fracture risk in humans. |
| format |
article |
| author |
Karin H. Nilsson Petra Henning Maha El Shahawy Maria Nethander Thomas Levin Andersen Charlotte Ejersted Jianyao Wu Karin L. Gustafsson Antti Koskela Juha Tuukkanen Pedro P. C. Souza Jan Tuckermann Mattias Lorentzon Linda Engström Ruud Terho Lehtimäki Jon H. Tobias Sirui Zhou Ulf H. Lerner J. Brent Richards Sofia Movérare-Skrtic Claes Ohlsson |
| author_facet |
Karin H. Nilsson Petra Henning Maha El Shahawy Maria Nethander Thomas Levin Andersen Charlotte Ejersted Jianyao Wu Karin L. Gustafsson Antti Koskela Juha Tuukkanen Pedro P. C. Souza Jan Tuckermann Mattias Lorentzon Linda Engström Ruud Terho Lehtimäki Jon H. Tobias Sirui Zhou Ulf H. Lerner J. Brent Richards Sofia Movérare-Skrtic Claes Ohlsson |
| author_sort |
Karin H. Nilsson |
| title |
RSPO3 is important for trabecular bone and fracture risk in mice and humans |
| title_short |
RSPO3 is important for trabecular bone and fracture risk in mice and humans |
| title_full |
RSPO3 is important for trabecular bone and fracture risk in mice and humans |
| title_fullStr |
RSPO3 is important for trabecular bone and fracture risk in mice and humans |
| title_full_unstemmed |
RSPO3 is important for trabecular bone and fracture risk in mice and humans |
| title_sort |
rspo3 is important for trabecular bone and fracture risk in mice and humans |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/bb0475854da041a2990d5eeb48bf5cee |
| work_keys_str_mv |
AT karinhnilsson rspo3isimportantfortrabecularboneandfractureriskinmiceandhumans AT petrahenning rspo3isimportantfortrabecularboneandfractureriskinmiceandhumans AT mahaelshahawy rspo3isimportantfortrabecularboneandfractureriskinmiceandhumans AT marianethander rspo3isimportantfortrabecularboneandfractureriskinmiceandhumans AT thomaslevinandersen rspo3isimportantfortrabecularboneandfractureriskinmiceandhumans AT charlotteejersted rspo3isimportantfortrabecularboneandfractureriskinmiceandhumans AT jianyaowu rspo3isimportantfortrabecularboneandfractureriskinmiceandhumans AT karinlgustafsson rspo3isimportantfortrabecularboneandfractureriskinmiceandhumans AT anttikoskela rspo3isimportantfortrabecularboneandfractureriskinmiceandhumans AT juhatuukkanen rspo3isimportantfortrabecularboneandfractureriskinmiceandhumans AT pedropcsouza rspo3isimportantfortrabecularboneandfractureriskinmiceandhumans AT jantuckermann rspo3isimportantfortrabecularboneandfractureriskinmiceandhumans AT mattiaslorentzon rspo3isimportantfortrabecularboneandfractureriskinmiceandhumans AT lindaengstromruud rspo3isimportantfortrabecularboneandfractureriskinmiceandhumans AT terholehtimaki rspo3isimportantfortrabecularboneandfractureriskinmiceandhumans AT jonhtobias rspo3isimportantfortrabecularboneandfractureriskinmiceandhumans AT siruizhou rspo3isimportantfortrabecularboneandfractureriskinmiceandhumans AT ulfhlerner rspo3isimportantfortrabecularboneandfractureriskinmiceandhumans AT jbrentrichards rspo3isimportantfortrabecularboneandfractureriskinmiceandhumans AT sofiamoverareskrtic rspo3isimportantfortrabecularboneandfractureriskinmiceandhumans AT claesohlsson rspo3isimportantfortrabecularboneandfractureriskinmiceandhumans |
| _version_ |
1718377172504150016 |