Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds

Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds

Abstract Peripheral administration (oral, intranasal, intraperitoneal, intravenous) of assembled A53T α-synuclein induced synucleinopathy in heterozygous mice transgenic for human mutant A53T α-synuclein (line M83). The same was the case when cerebellar extracts from a case of multiple system atroph...

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Bibliographic Details
Main Authors: Jennifer A. Macdonald, John L. Chen, Masami Masuda-Suzukake, Manuel Schweighauser, Zane Jaunmuktane, Thomas Warner, Janice L. Holton, Annabelle Grossman, Richard Berks, Isabelle Lavenir, Michel Goedert
Format: article
Language:EN
Published: BMC 2021
Subjects:
α-Synuclein
Multiple system atrophy
Seeded assembly
Neurodegeneration
Microglia
Neurology. Diseases of the nervous system
RC346-429
Online Access:https://doaj.org/article/bb04ab8adf9d41ed8dc3cbb1e5c3ee4c
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