HDAC inhibitors act with 5-aza-2'-deoxycytidine to inhibit cell proliferation by suppressing removal of incorporated abases in lung cancer cells.

HDAC inhibitors act with 5-aza-2'-deoxycytidine to inhibit cell proliferation by suppressing removal of incorporated abases in lung cancer cells.

5-Aza-2'-deoxycytidine (5-aza-CdR) is used extensively as a demethylating agent and acts in concert with histone deacetylase inhibitors (HDACI) to induce apoptosis or inhibition of cell proliferation in human cancer cells. Whether the action of 5-aza-CdR in this synergistic effect results from...

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Autores principales: Guolin Chai, Lian Li, Wen Zhou, Lipeng Wu, Ying Zhao, Donglai Wang, Shaoli Lu, Yu Yu, Haiying Wang, Michael A McNutt, Ye-Guang Hu, Yingqi Chen, Yang Yang, Xin Wu, Gregory A Otterson, Wei-Guo Zhu
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2008
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/bb0948831c134fafa74209741842ac68
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