Implications of photodynamic cancer therapy: an overview of PDT mechanisms basically and practically

Abstract Background Tumor eradication is one of the most important challengeable categories in oncological studies. In this account, besides the molecular genetics methods including cell therapy, gene therapy, immunotherapy, and general cancer therapy procedures like surgery, radiotherapy, and chemo...

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Autores principales:	Nafiseh Sobhani, Ali Akbar Samadani
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Photodynamic cancer therapy Mechanisms Oncological studies Cancerous tissues and cells Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/bb09ca7341e84569b0fff1f24c20350e
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spelling	oai:doaj.org-article:bb09ca7341e84569b0fff1f24c20350e2021-11-21T12:06:31ZImplications of photodynamic cancer therapy: an overview of PDT mechanisms basically and practically10.1186/s43046-021-00093-12589-0409https://doaj.org/article/bb09ca7341e84569b0fff1f24c20350e2021-11-01T00:00:00Zhttps://doi.org/10.1186/s43046-021-00093-1https://doaj.org/toc/2589-0409Abstract Background Tumor eradication is one of the most important challengeable categories in oncological studies. In this account, besides the molecular genetics methods including cell therapy, gene therapy, immunotherapy, and general cancer therapy procedures like surgery, radiotherapy, and chemotherapy, photodynamic adjuvant therapy is of great importance. Photodynamic therapy (PDT) as a relatively noninvasive therapeutic method utilizes the irradiation of an appropriate wavelength which is absorbed by a photosensitizing agent in the presence of oxygen. Main body of the abstract In this procedure, a series of events lead to the direct death of malignant cells such as damage to the microvasculature and also the induction of a local inflammatory function. PDT has participated with other treatment modalities especially in the early stage of malignant tumors and has resulted in decreasing morbidity besides improving survival rate and quality of life. High spatial resolution of PDT has attracted considerable attention in the field of image-guided photodynamic therapy combined with chemotherapy of multidrug resistance cancers. Although PDT outcomes vary across the different tumor types, minimal natural tissue toxicity, minor systemic effects, significant reduction in long-term disease, lack of innate or acquired resistance mechanisms, and excellent cosmetic effects, as well as limb function, make it a valuable treatment option for combination therapies. Short conclusion In this review article, we tried to discuss the potential of PDT in the treatment of some dermatologic and solid tumors, particularly all its important mechanisms.Nafiseh SobhaniAli Akbar SamadaniSpringerOpenarticlePhotodynamic cancer therapyMechanismsOncological studiesCancerous tissues and cellsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENJournal of the Egyptian National Cancer Institute, Vol 33, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Photodynamic cancer therapy Mechanisms Oncological studies Cancerous tissues and cells Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Photodynamic cancer therapy Mechanisms Oncological studies Cancerous tissues and cells Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Nafiseh Sobhani Ali Akbar Samadani Implications of photodynamic cancer therapy: an overview of PDT mechanisms basically and practically
description	Abstract Background Tumor eradication is one of the most important challengeable categories in oncological studies. In this account, besides the molecular genetics methods including cell therapy, gene therapy, immunotherapy, and general cancer therapy procedures like surgery, radiotherapy, and chemotherapy, photodynamic adjuvant therapy is of great importance. Photodynamic therapy (PDT) as a relatively noninvasive therapeutic method utilizes the irradiation of an appropriate wavelength which is absorbed by a photosensitizing agent in the presence of oxygen. Main body of the abstract In this procedure, a series of events lead to the direct death of malignant cells such as damage to the microvasculature and also the induction of a local inflammatory function. PDT has participated with other treatment modalities especially in the early stage of malignant tumors and has resulted in decreasing morbidity besides improving survival rate and quality of life. High spatial resolution of PDT has attracted considerable attention in the field of image-guided photodynamic therapy combined with chemotherapy of multidrug resistance cancers. Although PDT outcomes vary across the different tumor types, minimal natural tissue toxicity, minor systemic effects, significant reduction in long-term disease, lack of innate or acquired resistance mechanisms, and excellent cosmetic effects, as well as limb function, make it a valuable treatment option for combination therapies. Short conclusion In this review article, we tried to discuss the potential of PDT in the treatment of some dermatologic and solid tumors, particularly all its important mechanisms.
format	article
author	Nafiseh Sobhani Ali Akbar Samadani
author_facet	Nafiseh Sobhani Ali Akbar Samadani
author_sort	Nafiseh Sobhani
title	Implications of photodynamic cancer therapy: an overview of PDT mechanisms basically and practically
title_short	Implications of photodynamic cancer therapy: an overview of PDT mechanisms basically and practically
title_full	Implications of photodynamic cancer therapy: an overview of PDT mechanisms basically and practically
title_fullStr	Implications of photodynamic cancer therapy: an overview of PDT mechanisms basically and practically
title_full_unstemmed	Implications of photodynamic cancer therapy: an overview of PDT mechanisms basically and practically
title_sort	implications of photodynamic cancer therapy: an overview of pdt mechanisms basically and practically
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/bb09ca7341e84569b0fff1f24c20350e
work_keys_str_mv	AT nafisehsobhani implicationsofphotodynamiccancertherapyanoverviewofpdtmechanismsbasicallyandpractically AT aliakbarsamadani implicationsofphotodynamiccancertherapyanoverviewofpdtmechanismsbasicallyandpractically
_version_	1718419268451696640

Implications of photodynamic cancer therapy: an overview of PDT mechanisms basically and practically

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