Association of SLC6A4 methylation with long-term outcomes after stroke: focus on the interaction with suicidal ideation

Abstract Serotonin (5-HT) plays an important role in cerebrovascular homeostasis and psychiatric disorders, including suicidality. Methylation of the serotonin transporter gene (SLC6A4) is associated with 5-HT expression. However, the prognostic roles of SLC6A4 methylation and suicidal ideation (SI)...

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Autores principales:	Hee-Ju Kang, Eun-Hye Lee, Ju-Wan Kim, Sung-Wan Kim, Il-Seon Shin, Joon-Tae Kim, Man-Seok Park, Ki-Hyun Cho, Jung-Soo Han, In Kyoon Lyoo, Jae-Min Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bb0bc55c5bec419d8b28043349010ea6
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spelling	oai:doaj.org-article:bb0bc55c5bec419d8b28043349010ea62021-12-02T14:06:19ZAssociation of SLC6A4 methylation with long-term outcomes after stroke: focus on the interaction with suicidal ideation10.1038/s41598-021-81854-92045-2322https://doaj.org/article/bb0bc55c5bec419d8b28043349010ea62021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81854-9https://doaj.org/toc/2045-2322Abstract Serotonin (5-HT) plays an important role in cerebrovascular homeostasis and psychiatric disorders, including suicidality. Methylation of the serotonin transporter gene (SLC6A4) is associated with 5-HT expression. However, the prognostic roles of SLC6A4 methylation and suicidal ideation (SI) in long-term outcomes of stroke have not been evaluated. We investigated the independent and interactive effects of SLC6A4 methylation and SI immediately after stroke on long-term outcomes. Blood SLC6A4 methylation status and SI based on the suicide item of the Montgomery–Åsberg Depression Rating Scale were assessed in 278 patients at 2 weeks after stroke. After the index stroke, cerebro-cardiovascular events by SLC6A4 methylation status and SI were investigated over an 8–14-year follow-up period and using Cox regression models adjusted for a range of covariates. SLC6A4 hypermethylation and SI within 2 weeks of stroke both predicted worse long-term outcomes, independent of covariates. A significant interaction effect of SI and the methylation status of CpG 4 on long-term stroke outcomes was also identified. The association between SLC6A4 methylation and long-term adverse outcomes may be strengthened in the presence of SI within 2 weeks after stroke. Evaluation of methylation and SI status during the acute phase can be helpful when assessing stroke patients.Hee-Ju KangEun-Hye LeeJu-Wan KimSung-Wan KimIl-Seon ShinJoon-Tae KimMan-Seok ParkKi-Hyun ChoJung-Soo HanIn Kyoon LyooJae-Min KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hee-Ju Kang Eun-Hye Lee Ju-Wan Kim Sung-Wan Kim Il-Seon Shin Joon-Tae Kim Man-Seok Park Ki-Hyun Cho Jung-Soo Han In Kyoon Lyoo Jae-Min Kim Association of SLC6A4 methylation with long-term outcomes after stroke: focus on the interaction with suicidal ideation
description	Abstract Serotonin (5-HT) plays an important role in cerebrovascular homeostasis and psychiatric disorders, including suicidality. Methylation of the serotonin transporter gene (SLC6A4) is associated with 5-HT expression. However, the prognostic roles of SLC6A4 methylation and suicidal ideation (SI) in long-term outcomes of stroke have not been evaluated. We investigated the independent and interactive effects of SLC6A4 methylation and SI immediately after stroke on long-term outcomes. Blood SLC6A4 methylation status and SI based on the suicide item of the Montgomery–Åsberg Depression Rating Scale were assessed in 278 patients at 2 weeks after stroke. After the index stroke, cerebro-cardiovascular events by SLC6A4 methylation status and SI were investigated over an 8–14-year follow-up period and using Cox regression models adjusted for a range of covariates. SLC6A4 hypermethylation and SI within 2 weeks of stroke both predicted worse long-term outcomes, independent of covariates. A significant interaction effect of SI and the methylation status of CpG 4 on long-term stroke outcomes was also identified. The association between SLC6A4 methylation and long-term adverse outcomes may be strengthened in the presence of SI within 2 weeks after stroke. Evaluation of methylation and SI status during the acute phase can be helpful when assessing stroke patients.
format	article
author	Hee-Ju Kang Eun-Hye Lee Ju-Wan Kim Sung-Wan Kim Il-Seon Shin Joon-Tae Kim Man-Seok Park Ki-Hyun Cho Jung-Soo Han In Kyoon Lyoo Jae-Min Kim
author_facet	Hee-Ju Kang Eun-Hye Lee Ju-Wan Kim Sung-Wan Kim Il-Seon Shin Joon-Tae Kim Man-Seok Park Ki-Hyun Cho Jung-Soo Han In Kyoon Lyoo Jae-Min Kim
author_sort	Hee-Ju Kang
title	Association of SLC6A4 methylation with long-term outcomes after stroke: focus on the interaction with suicidal ideation
title_short	Association of SLC6A4 methylation with long-term outcomes after stroke: focus on the interaction with suicidal ideation
title_full	Association of SLC6A4 methylation with long-term outcomes after stroke: focus on the interaction with suicidal ideation
title_fullStr	Association of SLC6A4 methylation with long-term outcomes after stroke: focus on the interaction with suicidal ideation
title_full_unstemmed	Association of SLC6A4 methylation with long-term outcomes after stroke: focus on the interaction with suicidal ideation
title_sort	association of slc6a4 methylation with long-term outcomes after stroke: focus on the interaction with suicidal ideation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bb0bc55c5bec419d8b28043349010ea6
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Association of SLC6A4 methylation with long-term outcomes after stroke: focus on the interaction with suicidal ideation

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