Sirtuin 3 (SIRT3) Pathways in Age-Related Cardiovascular and Neurodegenerative Diseases

Age-associated cardiovascular and neurodegenerative diseases lead to high morbidity and mortality around the world. Sirtuins are vital enzymes for metabolic adaptation and provide protective effects against a wide spectrum of pathologies. Among sirtuins, mitochondrial sirtuin 3 (SIRT3) is an essenti...

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Autores principales:	Ciprian N. Silaghi, Marius Farcaș, Alexandra M. Crăciun
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SIRT3 aging neurodegenerative disease cardiovascular disease NAD<sup>+</sup> acetylation Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/bb0be764eee542fd8a06d237654fe633
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spelling	oai:doaj.org-article:bb0be764eee542fd8a06d237654fe6332021-11-25T16:49:10ZSirtuin 3 (SIRT3) Pathways in Age-Related Cardiovascular and Neurodegenerative Diseases10.3390/biomedicines91115742227-9059https://doaj.org/article/bb0be764eee542fd8a06d237654fe6332021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1574https://doaj.org/toc/2227-9059Age-associated cardiovascular and neurodegenerative diseases lead to high morbidity and mortality around the world. Sirtuins are vital enzymes for metabolic adaptation and provide protective effects against a wide spectrum of pathologies. Among sirtuins, mitochondrial sirtuin 3 (SIRT3) is an essential player in preserving the habitual metabolic profile. SIRT3 activity declines as a result of aging-induced changes in cellular metabolism, leading to increased susceptibility to endothelial dysfunction, hypertension, heart failure and neurodegenerative diseases. Stimulating SIRT3 activity via lifestyle, pharmacological or genetic interventions could protect against a plethora of pathologies and could improve health and lifespan. Thus, understanding how SIRT3 operates and how its protective effects could be amplified, will aid in treating age-associated diseases and ultimately, in enhancing the quality of life in elders.Ciprian N. SilaghiMarius FarcașAlexandra M. CrăciunMDPI AGarticleSIRT3agingneurodegenerative diseasecardiovascular diseaseNAD<sup>+</sup>acetylationBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1574, p 1574 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SIRT3 aging neurodegenerative disease cardiovascular disease NAD<sup>+</sup> acetylation Biology (General) QH301-705.5
spellingShingle	SIRT3 aging neurodegenerative disease cardiovascular disease NAD<sup>+</sup> acetylation Biology (General) QH301-705.5 Ciprian N. Silaghi Marius Farcaș Alexandra M. Crăciun Sirtuin 3 (SIRT3) Pathways in Age-Related Cardiovascular and Neurodegenerative Diseases
description	Age-associated cardiovascular and neurodegenerative diseases lead to high morbidity and mortality around the world. Sirtuins are vital enzymes for metabolic adaptation and provide protective effects against a wide spectrum of pathologies. Among sirtuins, mitochondrial sirtuin 3 (SIRT3) is an essential player in preserving the habitual metabolic profile. SIRT3 activity declines as a result of aging-induced changes in cellular metabolism, leading to increased susceptibility to endothelial dysfunction, hypertension, heart failure and neurodegenerative diseases. Stimulating SIRT3 activity via lifestyle, pharmacological or genetic interventions could protect against a plethora of pathologies and could improve health and lifespan. Thus, understanding how SIRT3 operates and how its protective effects could be amplified, will aid in treating age-associated diseases and ultimately, in enhancing the quality of life in elders.
format	article
author	Ciprian N. Silaghi Marius Farcaș Alexandra M. Crăciun
author_facet	Ciprian N. Silaghi Marius Farcaș Alexandra M. Crăciun
author_sort	Ciprian N. Silaghi
title	Sirtuin 3 (SIRT3) Pathways in Age-Related Cardiovascular and Neurodegenerative Diseases
title_short	Sirtuin 3 (SIRT3) Pathways in Age-Related Cardiovascular and Neurodegenerative Diseases
title_full	Sirtuin 3 (SIRT3) Pathways in Age-Related Cardiovascular and Neurodegenerative Diseases
title_fullStr	Sirtuin 3 (SIRT3) Pathways in Age-Related Cardiovascular and Neurodegenerative Diseases
title_full_unstemmed	Sirtuin 3 (SIRT3) Pathways in Age-Related Cardiovascular and Neurodegenerative Diseases
title_sort	sirtuin 3 (sirt3) pathways in age-related cardiovascular and neurodegenerative diseases
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bb0be764eee542fd8a06d237654fe633
work_keys_str_mv	AT cipriannsilaghi sirtuin3sirt3pathwaysinagerelatedcardiovascularandneurodegenerativediseases AT mariusfarcas sirtuin3sirt3pathwaysinagerelatedcardiovascularandneurodegenerativediseases AT alexandramcraciun sirtuin3sirt3pathwaysinagerelatedcardiovascularandneurodegenerativediseases
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Sirtuin 3 (SIRT3) Pathways in Age-Related Cardiovascular and Neurodegenerative Diseases

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