Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis
Knut A Hestad,1–3 Knut Engedal,4 Jon Elling Whist,1 Pål Aukrust,5–9 Per G Farup,1,10 Tom Eirik Mollnes,9,11–13 Thor Ueland5,7,91Department of Research, Innlandet Hospital Trust, Brumunddal, 2Department of Psychology, Faculty of Social Sciences and Technology M...
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Dove Medical Press
2016
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oai:doaj.org-article:bb0c30bfda054876a41adc74cf3113492021-12-02T03:59:16ZPatients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis1178-2021https://doaj.org/article/bb0c30bfda054876a41adc74cf3113492016-04-01T00:00:00Zhttps://www.dovepress.com/patients-with-depression-display-cytokine-levels-in-serum-and-cerebros-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Knut A Hestad,1–3 Knut Engedal,4 Jon Elling Whist,1 Pål Aukrust,5–9 Per G Farup,1,10 Tom Eirik Mollnes,9,11–13 Thor Ueland5,7,91Department of Research, Innlandet Hospital Trust, Brumunddal, 2Department of Psychology, Faculty of Social Sciences and Technology Management, Norwegian University of Science and Technology (NTNU), Trondheim, 3Department of Public Health, Hedmark University College, Elverum, 4Norwegian Centre for Aging and Health, Vestfold Health Trust, Tønsberg, 5Research Institute of Internal Medicine, 6Section of Clinical Immunology and Infectious Diseases, 7Institute of Clinical Medicine, Oslo University Hospital Rikshospitalet, 8K.G. Jebsen IRC, University of Oslo, Oslo, 9K.G. Jebsen TREC, University of Tromsø, Tromsø, 10Unit for Applied Clinical Research, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, 11Centre of Molecular Inflammation Research, Norwegian University of Science and Technology (NTNU), Trondheim, 12Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, 13Research Laboratory, Nordland Hospital, Bodø, NorwayIntroduction: Several reports indicate that inflammation may play a role in depression and demonstrate enhanced systemic levels of inflammatory mediators. We hypothesized that 44 patients with a diagnosis of depression would present with a specific and different serum and cerebrospinal fluid (CSF) cytokine profile compared to 21 patients with diffuse neurological symptoms, of whom 15 had fatigue as a major symptom, but no change in emotional state.Methods: The diagnoses of the patients with depression were according to the International Classification of Diseases, tenth edition (F32–34 spectra). Cytokine profiles in serum and CSF were determined by multiplex analysis, including 27 cytokines, chemokines, and growth factors.Results: No differences could be found between the two groups studied regarding cytokine levels in serum or CSF except for serum interleukin (IL)-1 receptor antagonist that was lower in the depression group. There were only four high correlations (>0.4) between serum and CSF levels of the cytokines, reflecting independent synthesis and turnover in these two compartments. In the control group, fatigue was associated with increased IL-1 receptor antagonist, IL-10, granulocyte-colony stimulating factor, and interferon-γ (all P<0.01).Conclusion: Patients with depression had a similar cytokine profile as nondepressive patients, both systemically and in CSF. Fatigue was associated with higher levels of some inflammatory markers in the control group. It is possible that the presence of fatigue in a large proportion of patients and controls could contribute to the lack of difference in cytokine levels between these two groups.Keywords: depression, cytokines, chemokines, inflammation, fatigue, serum, CSF, multiplex analysisHestad KAEngedal KWhist JEAukrust PFarup PGMollnes TEUelTDove Medical PressarticleDepressioncytokineschemokinesinflammationfatigueserumCSFMultiplex analysis.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 817-822 (2016) |
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Depression cytokines chemokines inflammation fatigue serum CSF Multiplex analysis. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
Depression cytokines chemokines inflammation fatigue serum CSF Multiplex analysis. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Hestad KA Engedal K Whist JE Aukrust P Farup PG Mollnes TE Uel T Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis |
| description |
Knut A Hestad,1–3 Knut Engedal,4 Jon Elling Whist,1 Pål Aukrust,5–9 Per G Farup,1,10 Tom Eirik Mollnes,9,11–13 Thor Ueland5,7,91Department of Research, Innlandet Hospital Trust, Brumunddal, 2Department of Psychology, Faculty of Social Sciences and Technology Management, Norwegian University of Science and Technology (NTNU), Trondheim, 3Department of Public Health, Hedmark University College, Elverum, 4Norwegian Centre for Aging and Health, Vestfold Health Trust, Tønsberg, 5Research Institute of Internal Medicine, 6Section of Clinical Immunology and Infectious Diseases, 7Institute of Clinical Medicine, Oslo University Hospital Rikshospitalet, 8K.G. Jebsen IRC, University of Oslo, Oslo, 9K.G. Jebsen TREC, University of Tromsø, Tromsø, 10Unit for Applied Clinical Research, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, 11Centre of Molecular Inflammation Research, Norwegian University of Science and Technology (NTNU), Trondheim, 12Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, 13Research Laboratory, Nordland Hospital, Bodø, NorwayIntroduction: Several reports indicate that inflammation may play a role in depression and demonstrate enhanced systemic levels of inflammatory mediators. We hypothesized that 44 patients with a diagnosis of depression would present with a specific and different serum and cerebrospinal fluid (CSF) cytokine profile compared to 21 patients with diffuse neurological symptoms, of whom 15 had fatigue as a major symptom, but no change in emotional state.Methods: The diagnoses of the patients with depression were according to the International Classification of Diseases, tenth edition (F32–34 spectra). Cytokine profiles in serum and CSF were determined by multiplex analysis, including 27 cytokines, chemokines, and growth factors.Results: No differences could be found between the two groups studied regarding cytokine levels in serum or CSF except for serum interleukin (IL)-1 receptor antagonist that was lower in the depression group. There were only four high correlations (>0.4) between serum and CSF levels of the cytokines, reflecting independent synthesis and turnover in these two compartments. In the control group, fatigue was associated with increased IL-1 receptor antagonist, IL-10, granulocyte-colony stimulating factor, and interferon-γ (all P<0.01).Conclusion: Patients with depression had a similar cytokine profile as nondepressive patients, both systemically and in CSF. Fatigue was associated with higher levels of some inflammatory markers in the control group. It is possible that the presence of fatigue in a large proportion of patients and controls could contribute to the lack of difference in cytokine levels between these two groups.Keywords: depression, cytokines, chemokines, inflammation, fatigue, serum, CSF, multiplex analysis |
| format |
article |
| author |
Hestad KA Engedal K Whist JE Aukrust P Farup PG Mollnes TE Uel T |
| author_facet |
Hestad KA Engedal K Whist JE Aukrust P Farup PG Mollnes TE Uel T |
| author_sort |
Hestad KA |
| title |
Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis |
| title_short |
Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis |
| title_full |
Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis |
| title_fullStr |
Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis |
| title_full_unstemmed |
Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis |
| title_sort |
patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis |
| publisher |
Dove Medical Press |
| publishDate |
2016 |
| url |
https://doaj.org/article/bb0c30bfda054876a41adc74cf311349 |
| work_keys_str_mv |
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