Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells
Non-obstructive azoospermia affects 1% of men. Here, authors perform single-cell transcriptomic analysis of human testicular cells from healthy donors and non-obstructive azoospermia patients and find that inhibition of Wnt signaling promotes the maturation of Sertoli cells from patients.
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Nature Portfolio
2020
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oai:doaj.org-article:bb0fbe49441045209c09d3f5a07f28af2021-12-02T15:39:22ZSingle-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells10.1038/s41467-020-19414-42041-1723https://doaj.org/article/bb0fbe49441045209c09d3f5a07f28af2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19414-4https://doaj.org/toc/2041-1723Non-obstructive azoospermia affects 1% of men. Here, authors perform single-cell transcriptomic analysis of human testicular cells from healthy donors and non-obstructive azoospermia patients and find that inhibition of Wnt signaling promotes the maturation of Sertoli cells from patients.LiangYu ZhaoChenCheng YaoXiaoYu XingTao JingPeng LiZiJue ZhuChao YangJing ZhaiRuHui TianHuiXing ChenJiaQiang LuoNaChuan LiuZhiWen DengXiaoHan LinNa LiJing FangJie SunChenChen WangZhi ZhouZheng LiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
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DOAJ |
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DOAJ |
| language |
EN |
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Science Q |
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Science Q LiangYu Zhao ChenCheng Yao XiaoYu Xing Tao Jing Peng Li ZiJue Zhu Chao Yang Jing Zhai RuHui Tian HuiXing Chen JiaQiang Luo NaChuan Liu ZhiWen Deng XiaoHan Lin Na Li Jing Fang Jie Sun ChenChen Wang Zhi Zhou Zheng Li Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells |
| description |
Non-obstructive azoospermia affects 1% of men. Here, authors perform single-cell transcriptomic analysis of human testicular cells from healthy donors and non-obstructive azoospermia patients and find that inhibition of Wnt signaling promotes the maturation of Sertoli cells from patients. |
| format |
article |
| author |
LiangYu Zhao ChenCheng Yao XiaoYu Xing Tao Jing Peng Li ZiJue Zhu Chao Yang Jing Zhai RuHui Tian HuiXing Chen JiaQiang Luo NaChuan Liu ZhiWen Deng XiaoHan Lin Na Li Jing Fang Jie Sun ChenChen Wang Zhi Zhou Zheng Li |
| author_facet |
LiangYu Zhao ChenCheng Yao XiaoYu Xing Tao Jing Peng Li ZiJue Zhu Chao Yang Jing Zhai RuHui Tian HuiXing Chen JiaQiang Luo NaChuan Liu ZhiWen Deng XiaoHan Lin Na Li Jing Fang Jie Sun ChenChen Wang Zhi Zhou Zheng Li |
| author_sort |
LiangYu Zhao |
| title |
Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells |
| title_short |
Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells |
| title_full |
Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells |
| title_fullStr |
Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells |
| title_full_unstemmed |
Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells |
| title_sort |
single-cell analysis of developing and azoospermia human testicles reveals central role of sertoli cells |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/bb0fbe49441045209c09d3f5a07f28af |
| work_keys_str_mv |
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| _version_ |
1718385955547643904 |