Thymol-loaded PLGA nanoparticles: an efficient approach for acne treatment

Abstract Background Acne is a common skin disorder that involves an infection inside the hair follicle, which is usually treated with antibiotics, resulting in unbalanced skin microbiota and microbial resistance. For this reason, we developed polymeric nanoparticles encapsulating thymol, a natural a...

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Autores principales:	Camila Folle, Ana M. Marqués, Natalia Díaz-Garrido, Marta Espina, Elena Sánchez-López, Josefa Badia, Laura Baldoma, Ana Cristina Calpena, Maria Luisa García
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Acne Thymol PLGA nanoparticles Skin delivery system Cutibacterium acnes Skin microbiota Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/bb1023f529cb4868a53a8fa11c35b198
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spelling	oai:doaj.org-article:bb1023f529cb4868a53a8fa11c35b1982021-11-14T12:29:25ZThymol-loaded PLGA nanoparticles: an efficient approach for acne treatment10.1186/s12951-021-01092-z1477-3155https://doaj.org/article/bb1023f529cb4868a53a8fa11c35b1982021-11-01T00:00:00Zhttps://doi.org/10.1186/s12951-021-01092-zhttps://doaj.org/toc/1477-3155Abstract Background Acne is a common skin disorder that involves an infection inside the hair follicle, which is usually treated with antibiotics, resulting in unbalanced skin microbiota and microbial resistance. For this reason, we developed polymeric nanoparticles encapsulating thymol, a natural active compound with antimicrobial and antioxidant properties. In this work, optimization physicochemical characterization, biopharmaceutical behavior and therapeutic efficacy of this novel nanostructured system were assessed. Results Thymol NPs (TH-NP) resulted on suitable average particle size below 200 nm with a surface charge around − 28 mV and high encapsulation efficiency (80%). TH-NP released TH in a sustained manner and provide a slow-rate penetration into the hair follicle, being highly retained inside the skin. TH-NP possess a potent antimicrobial activity against Cutibacterium acnes and minor effect towards Staphylococcus epidermis, the major resident of the healthy skin microbiota. Additionally, the stability and sterility of developed NPs were maintained along storage. Conclusion TH-NP showed a promising and efficient alternative for the treatment of skin acne infection, avoiding antibiotic administration, reducing side effects, and preventing microbial drug resistance, without altering the healthy skin microbiota. Additionally, TH-NP enhanced TH antioxidant activity, constituting a natural, preservative-free, approach for acne treatment. Graphical AbstractCamila FolleAna M. MarquésNatalia Díaz-GarridoMarta EspinaElena Sánchez-LópezJosefa BadiaLaura BaldomaAna Cristina CalpenaMaria Luisa GarcíaBMCarticleAcneThymolPLGA nanoparticlesSkin delivery systemCutibacterium acnesSkin microbiotaBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENJournal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Acne Thymol PLGA nanoparticles Skin delivery system Cutibacterium acnes Skin microbiota Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	Acne Thymol PLGA nanoparticles Skin delivery system Cutibacterium acnes Skin microbiota Biotechnology TP248.13-248.65 Medical technology R855-855.5 Camila Folle Ana M. Marqués Natalia Díaz-Garrido Marta Espina Elena Sánchez-López Josefa Badia Laura Baldoma Ana Cristina Calpena Maria Luisa García Thymol-loaded PLGA nanoparticles: an efficient approach for acne treatment
description	Abstract Background Acne is a common skin disorder that involves an infection inside the hair follicle, which is usually treated with antibiotics, resulting in unbalanced skin microbiota and microbial resistance. For this reason, we developed polymeric nanoparticles encapsulating thymol, a natural active compound with antimicrobial and antioxidant properties. In this work, optimization physicochemical characterization, biopharmaceutical behavior and therapeutic efficacy of this novel nanostructured system were assessed. Results Thymol NPs (TH-NP) resulted on suitable average particle size below 200 nm with a surface charge around − 28 mV and high encapsulation efficiency (80%). TH-NP released TH in a sustained manner and provide a slow-rate penetration into the hair follicle, being highly retained inside the skin. TH-NP possess a potent antimicrobial activity against Cutibacterium acnes and minor effect towards Staphylococcus epidermis, the major resident of the healthy skin microbiota. Additionally, the stability and sterility of developed NPs were maintained along storage. Conclusion TH-NP showed a promising and efficient alternative for the treatment of skin acne infection, avoiding antibiotic administration, reducing side effects, and preventing microbial drug resistance, without altering the healthy skin microbiota. Additionally, TH-NP enhanced TH antioxidant activity, constituting a natural, preservative-free, approach for acne treatment. Graphical Abstract
format	article
author	Camila Folle Ana M. Marqués Natalia Díaz-Garrido Marta Espina Elena Sánchez-López Josefa Badia Laura Baldoma Ana Cristina Calpena Maria Luisa García
author_facet	Camila Folle Ana M. Marqués Natalia Díaz-Garrido Marta Espina Elena Sánchez-López Josefa Badia Laura Baldoma Ana Cristina Calpena Maria Luisa García
author_sort	Camila Folle
title	Thymol-loaded PLGA nanoparticles: an efficient approach for acne treatment
title_short	Thymol-loaded PLGA nanoparticles: an efficient approach for acne treatment
title_full	Thymol-loaded PLGA nanoparticles: an efficient approach for acne treatment
title_fullStr	Thymol-loaded PLGA nanoparticles: an efficient approach for acne treatment
title_full_unstemmed	Thymol-loaded PLGA nanoparticles: an efficient approach for acne treatment
title_sort	thymol-loaded plga nanoparticles: an efficient approach for acne treatment
publisher	BMC
publishDate	2021
url	https://doaj.org/article/bb1023f529cb4868a53a8fa11c35b198
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Thymol-loaded PLGA nanoparticles: an efficient approach for acne treatment

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