Transmission pathways of foot-and-mouth disease virus in the United Kingdom in 2007.
Foot-and-mouth disease (FMD) virus causes an acute vesicular disease of domesticated and wild ruminants and pigs. Identifying sources of FMD outbreaks is often confounded by incomplete epidemiological evidence and the numerous routes by which virus can spread (movements of infected animals or their...
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Public Library of Science (PLoS)
2008
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oai:doaj.org-article:bb10b8a5273d48d2a1096fc5857f887c2021-12-02T19:59:49ZTransmission pathways of foot-and-mouth disease virus in the United Kingdom in 2007.1553-73661553-737410.1371/journal.ppat.1000050https://doaj.org/article/bb10b8a5273d48d2a1096fc5857f887c2008-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18421380/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Foot-and-mouth disease (FMD) virus causes an acute vesicular disease of domesticated and wild ruminants and pigs. Identifying sources of FMD outbreaks is often confounded by incomplete epidemiological evidence and the numerous routes by which virus can spread (movements of infected animals or their products, contaminated persons, objects, and aerosols). Here, we show that the outbreaks of FMD in the United Kingdom in August 2007 were caused by a derivative of FMDV O(1) BFS 1860, a virus strain handled at two FMD laboratories located on a single site at Pirbright in Surrey. Genetic analysis of complete viral genomes generated in real-time reveals a probable chain of transmission events, predicting undisclosed infected premises, and connecting the second cluster of outbreaks in September to those in August. Complete genome sequence analysis of FMD viruses conducted in real-time have identified the initial and intermediate sources of these outbreaks and demonstrate the value of such techniques in providing information useful to contemporary disease control programmes.Eleanor M CottamJemma WadsworthAndrew E ShawRebecca J RowlandsLynnette GoatleySushila MaanNarender S MaanPeter P C MertensKatja EbertYanmin LiEoin D RyanNicholas JuleffNigel P FerrisJohn W WilesmithDaniel T HaydonDonald P KingDavid J PatonNick J KnowlesPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 4, Iss 4, p e1000050 (2008) |
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DOAJ |
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DOAJ |
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| topic |
Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 |
| spellingShingle |
Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Eleanor M Cottam Jemma Wadsworth Andrew E Shaw Rebecca J Rowlands Lynnette Goatley Sushila Maan Narender S Maan Peter P C Mertens Katja Ebert Yanmin Li Eoin D Ryan Nicholas Juleff Nigel P Ferris John W Wilesmith Daniel T Haydon Donald P King David J Paton Nick J Knowles Transmission pathways of foot-and-mouth disease virus in the United Kingdom in 2007. |
| description |
Foot-and-mouth disease (FMD) virus causes an acute vesicular disease of domesticated and wild ruminants and pigs. Identifying sources of FMD outbreaks is often confounded by incomplete epidemiological evidence and the numerous routes by which virus can spread (movements of infected animals or their products, contaminated persons, objects, and aerosols). Here, we show that the outbreaks of FMD in the United Kingdom in August 2007 were caused by a derivative of FMDV O(1) BFS 1860, a virus strain handled at two FMD laboratories located on a single site at Pirbright in Surrey. Genetic analysis of complete viral genomes generated in real-time reveals a probable chain of transmission events, predicting undisclosed infected premises, and connecting the second cluster of outbreaks in September to those in August. Complete genome sequence analysis of FMD viruses conducted in real-time have identified the initial and intermediate sources of these outbreaks and demonstrate the value of such techniques in providing information useful to contemporary disease control programmes. |
| format |
article |
| author |
Eleanor M Cottam Jemma Wadsworth Andrew E Shaw Rebecca J Rowlands Lynnette Goatley Sushila Maan Narender S Maan Peter P C Mertens Katja Ebert Yanmin Li Eoin D Ryan Nicholas Juleff Nigel P Ferris John W Wilesmith Daniel T Haydon Donald P King David J Paton Nick J Knowles |
| author_facet |
Eleanor M Cottam Jemma Wadsworth Andrew E Shaw Rebecca J Rowlands Lynnette Goatley Sushila Maan Narender S Maan Peter P C Mertens Katja Ebert Yanmin Li Eoin D Ryan Nicholas Juleff Nigel P Ferris John W Wilesmith Daniel T Haydon Donald P King David J Paton Nick J Knowles |
| author_sort |
Eleanor M Cottam |
| title |
Transmission pathways of foot-and-mouth disease virus in the United Kingdom in 2007. |
| title_short |
Transmission pathways of foot-and-mouth disease virus in the United Kingdom in 2007. |
| title_full |
Transmission pathways of foot-and-mouth disease virus in the United Kingdom in 2007. |
| title_fullStr |
Transmission pathways of foot-and-mouth disease virus in the United Kingdom in 2007. |
| title_full_unstemmed |
Transmission pathways of foot-and-mouth disease virus in the United Kingdom in 2007. |
| title_sort |
transmission pathways of foot-and-mouth disease virus in the united kingdom in 2007. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2008 |
| url |
https://doaj.org/article/bb10b8a5273d48d2a1096fc5857f887c |
| work_keys_str_mv |
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