Progesterone receptor membrane component 1 reduces cardiac steatosis and lipotoxicity via activation of fatty acid oxidation and mitochondrial respiration

Progesterone receptor membrane component 1 reduces cardiac steatosis and lipotoxicity via activation of fatty acid oxidation and mitochondrial respiration

Abstract Obesity is implicated in cardiovascular disease and heart failure. When fatty acids are transported to and not adequately oxidized in cardiac cells, they accumulate, causing lipotoxicity in the heart. Since hepatic progesterone receptor membrane component 1 (Pgrmc1) suppressed de novo lipog...

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Main Authors: Sang R. Lee, Jun H. Heo, Seong Lae Jo, Globinna Kim, Su Jung Kim, Hyun Ju Yoo, Kyu-Pil Lee, Hyo-Jung Kwun, Hyun-Jin Shin, In-Jeoung Baek, Eui-Ju Hong
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/bb10f57b600240b4adc861e06e95a419
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https://doaj.org/article/bb10f57b600240b4adc861e06e95a419

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