PROgnosticating COeliac patieNts SUrvivaL: the PROCONSUL score.
<h4>Introduction</h4>It has been shown that mortality rates of coeliac patients correlate with age at diagnosis of coeliac disease, diagnostic delay for coeliac disease, pattern of clinical presentation and HLA typing. Our aim was to create a tool that identifies coeliac patients at high...
Guardado en:
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2014
|
Materias: | |
Acceso en línea: | https://doaj.org/article/bb110dc44ef24f79af600043e400d857 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:bb110dc44ef24f79af600043e400d857 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:bb110dc44ef24f79af600043e400d8572021-11-18T08:39:07ZPROgnosticating COeliac patieNts SUrvivaL: the PROCONSUL score.1932-620310.1371/journal.pone.0084163https://doaj.org/article/bb110dc44ef24f79af600043e400d8572014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24392112/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>It has been shown that mortality rates of coeliac patients correlate with age at diagnosis of coeliac disease, diagnostic delay for coeliac disease, pattern of clinical presentation and HLA typing. Our aim was to create a tool that identifies coeliac patients at higher risk of developing complications.<h4>Methods</h4>To identify predictors of complications in patients with coeliac disease, we organised an observational multicenter case-control study based on a retrospective collection of clinical data. Clinical data from 116 cases (patients with complicated coeliac disease) and 181 controls (coeliac patients without any complications) were collected from seven European centres. For each case, one or two controls, matched to cases according to the year of assessment, gender and age, were selected. Diagnostic delay, pattern of clinical presentation, HLA typing and age at diagnosis were used as predictors.<h4>Results</h4>Differences between cases and controls were detected for diagnostic delay and classical presentation. Conditional logistic models based on these statistically different predictors allowed the development of a score system. Tertiles analysis showed a relationship between score and risk of developing complications.<h4>Discussion</h4>A score that shows the risk of a newly diagnosed coeliac patient developing complications was devised for the first time. This will make it possible to set up the follow-up of coeliac patients with great benefits not only for their health but also for management of economic resources.<h4>Conclusions</h4>We think that our results are very encouraging and represent the first attempt to build a prognostic score for coeliac patients.Federico BiagiAnnalisa SchiepattiGeorgia MalamutAlessandra MarcheseChristophe CellierSjoerd F BakkerChris J J MulderUmberto VoltaFabiana ZingoneCarolina CiacciAnna D'OdoricoAlida AndrealliMarco AstegianoCatherine KlersyGino R CorazzaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e84163 (2014) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Federico Biagi Annalisa Schiepatti Georgia Malamut Alessandra Marchese Christophe Cellier Sjoerd F Bakker Chris J J Mulder Umberto Volta Fabiana Zingone Carolina Ciacci Anna D'Odorico Alida Andrealli Marco Astegiano Catherine Klersy Gino R Corazza PROgnosticating COeliac patieNts SUrvivaL: the PROCONSUL score. |
description |
<h4>Introduction</h4>It has been shown that mortality rates of coeliac patients correlate with age at diagnosis of coeliac disease, diagnostic delay for coeliac disease, pattern of clinical presentation and HLA typing. Our aim was to create a tool that identifies coeliac patients at higher risk of developing complications.<h4>Methods</h4>To identify predictors of complications in patients with coeliac disease, we organised an observational multicenter case-control study based on a retrospective collection of clinical data. Clinical data from 116 cases (patients with complicated coeliac disease) and 181 controls (coeliac patients without any complications) were collected from seven European centres. For each case, one or two controls, matched to cases according to the year of assessment, gender and age, were selected. Diagnostic delay, pattern of clinical presentation, HLA typing and age at diagnosis were used as predictors.<h4>Results</h4>Differences between cases and controls were detected for diagnostic delay and classical presentation. Conditional logistic models based on these statistically different predictors allowed the development of a score system. Tertiles analysis showed a relationship between score and risk of developing complications.<h4>Discussion</h4>A score that shows the risk of a newly diagnosed coeliac patient developing complications was devised for the first time. This will make it possible to set up the follow-up of coeliac patients with great benefits not only for their health but also for management of economic resources.<h4>Conclusions</h4>We think that our results are very encouraging and represent the first attempt to build a prognostic score for coeliac patients. |
format |
article |
author |
Federico Biagi Annalisa Schiepatti Georgia Malamut Alessandra Marchese Christophe Cellier Sjoerd F Bakker Chris J J Mulder Umberto Volta Fabiana Zingone Carolina Ciacci Anna D'Odorico Alida Andrealli Marco Astegiano Catherine Klersy Gino R Corazza |
author_facet |
Federico Biagi Annalisa Schiepatti Georgia Malamut Alessandra Marchese Christophe Cellier Sjoerd F Bakker Chris J J Mulder Umberto Volta Fabiana Zingone Carolina Ciacci Anna D'Odorico Alida Andrealli Marco Astegiano Catherine Klersy Gino R Corazza |
author_sort |
Federico Biagi |
title |
PROgnosticating COeliac patieNts SUrvivaL: the PROCONSUL score. |
title_short |
PROgnosticating COeliac patieNts SUrvivaL: the PROCONSUL score. |
title_full |
PROgnosticating COeliac patieNts SUrvivaL: the PROCONSUL score. |
title_fullStr |
PROgnosticating COeliac patieNts SUrvivaL: the PROCONSUL score. |
title_full_unstemmed |
PROgnosticating COeliac patieNts SUrvivaL: the PROCONSUL score. |
title_sort |
prognosticating coeliac patients survival: the proconsul score. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doaj.org/article/bb110dc44ef24f79af600043e400d857 |
work_keys_str_mv |
AT federicobiagi prognosticatingcoeliacpatientssurvivaltheproconsulscore AT annalisaschiepatti prognosticatingcoeliacpatientssurvivaltheproconsulscore AT georgiamalamut prognosticatingcoeliacpatientssurvivaltheproconsulscore AT alessandramarchese prognosticatingcoeliacpatientssurvivaltheproconsulscore AT christophecellier prognosticatingcoeliacpatientssurvivaltheproconsulscore AT sjoerdfbakker prognosticatingcoeliacpatientssurvivaltheproconsulscore AT chrisjjmulder prognosticatingcoeliacpatientssurvivaltheproconsulscore AT umbertovolta prognosticatingcoeliacpatientssurvivaltheproconsulscore AT fabianazingone prognosticatingcoeliacpatientssurvivaltheproconsulscore AT carolinaciacci prognosticatingcoeliacpatientssurvivaltheproconsulscore AT annadodorico prognosticatingcoeliacpatientssurvivaltheproconsulscore AT alidaandrealli prognosticatingcoeliacpatientssurvivaltheproconsulscore AT marcoastegiano prognosticatingcoeliacpatientssurvivaltheproconsulscore AT catherineklersy prognosticatingcoeliacpatientssurvivaltheproconsulscore AT ginorcorazza prognosticatingcoeliacpatientssurvivaltheproconsulscore |
_version_ |
1718421524604518400 |