Increased resting-state cerebellar-cortical connectivity in breast cancer survivors with cognitive complaints after chemotherapy

Abstract Cognitive complaints after chemotherapy are common in breast cancer patients, but the neural bases for these complaints remain unclear. This pilot study explored resting-state functional connectivity (FC) as a marker of subtle cognitive changes in breast cancer patients who experience cogni...

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Autores principales:	Hye Yoon Park, Hyeongrae Lee, Joohyuk Sohn, Suk Kyoon An, Kee Namkoong, Eun Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bb1268496cff4f26bd392bceb3ce57a1
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spelling	oai:doaj.org-article:bb1268496cff4f26bd392bceb3ce57a12021-12-02T17:34:30ZIncreased resting-state cerebellar-cortical connectivity in breast cancer survivors with cognitive complaints after chemotherapy10.1038/s41598-021-91447-12045-2322https://doaj.org/article/bb1268496cff4f26bd392bceb3ce57a12021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91447-1https://doaj.org/toc/2045-2322Abstract Cognitive complaints after chemotherapy are common in breast cancer patients, but the neural bases for these complaints remain unclear. This pilot study explored resting-state functional connectivity (FC) as a marker of subtle cognitive changes in breast cancer patients who experience cognitive complaints. Chemotherapy-treated (n = 20, at least 6 months off therapy) and untreated (n = 17, disease-control) female breast cancer patients with cognitive complaints and healthy controls (n = 20) were recruited. The FC of the right dorsolateral prefrontal cortex was calculated, and any correlations between this FC and neuropsychological assessments were determined. Chemotherapy-treated patients with cognitive complaints displayed increased FC between the right dorsolateral prefrontal cortex and both the contralateral cerebellar lobule VII and the cerebellar vermis XI, compared to the disease-control and healthy-control groups, despite unimpaired neuropsychological performance. The increased FC was negatively correlated with executive function and attention in breast cancer survivors with cognitive complaints. Our pilot study findings provide evidence that cerebellar-cortical FC changes may be a pathophysiological basis for chemotherapy-related cognitive complaints. In addition, the FC changes have the potential to reflect minor or compensated cognitive function impairment in breast cancer patients.Hye Yoon ParkHyeongrae LeeJoohyuk SohnSuk Kyoon AnKee NamkoongEun LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hye Yoon Park Hyeongrae Lee Joohyuk Sohn Suk Kyoon An Kee Namkoong Eun Lee Increased resting-state cerebellar-cortical connectivity in breast cancer survivors with cognitive complaints after chemotherapy
description	Abstract Cognitive complaints after chemotherapy are common in breast cancer patients, but the neural bases for these complaints remain unclear. This pilot study explored resting-state functional connectivity (FC) as a marker of subtle cognitive changes in breast cancer patients who experience cognitive complaints. Chemotherapy-treated (n = 20, at least 6 months off therapy) and untreated (n = 17, disease-control) female breast cancer patients with cognitive complaints and healthy controls (n = 20) were recruited. The FC of the right dorsolateral prefrontal cortex was calculated, and any correlations between this FC and neuropsychological assessments were determined. Chemotherapy-treated patients with cognitive complaints displayed increased FC between the right dorsolateral prefrontal cortex and both the contralateral cerebellar lobule VII and the cerebellar vermis XI, compared to the disease-control and healthy-control groups, despite unimpaired neuropsychological performance. The increased FC was negatively correlated with executive function and attention in breast cancer survivors with cognitive complaints. Our pilot study findings provide evidence that cerebellar-cortical FC changes may be a pathophysiological basis for chemotherapy-related cognitive complaints. In addition, the FC changes have the potential to reflect minor or compensated cognitive function impairment in breast cancer patients.
format	article
author	Hye Yoon Park Hyeongrae Lee Joohyuk Sohn Suk Kyoon An Kee Namkoong Eun Lee
author_facet	Hye Yoon Park Hyeongrae Lee Joohyuk Sohn Suk Kyoon An Kee Namkoong Eun Lee
author_sort	Hye Yoon Park
title	Increased resting-state cerebellar-cortical connectivity in breast cancer survivors with cognitive complaints after chemotherapy
title_short	Increased resting-state cerebellar-cortical connectivity in breast cancer survivors with cognitive complaints after chemotherapy
title_full	Increased resting-state cerebellar-cortical connectivity in breast cancer survivors with cognitive complaints after chemotherapy
title_fullStr	Increased resting-state cerebellar-cortical connectivity in breast cancer survivors with cognitive complaints after chemotherapy
title_full_unstemmed	Increased resting-state cerebellar-cortical connectivity in breast cancer survivors with cognitive complaints after chemotherapy
title_sort	increased resting-state cerebellar-cortical connectivity in breast cancer survivors with cognitive complaints after chemotherapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bb1268496cff4f26bd392bceb3ce57a1
work_keys_str_mv	AT hyeyoonpark increasedrestingstatecerebellarcorticalconnectivityinbreastcancersurvivorswithcognitivecomplaintsafterchemotherapy AT hyeongraelee increasedrestingstatecerebellarcorticalconnectivityinbreastcancersurvivorswithcognitivecomplaintsafterchemotherapy AT joohyuksohn increasedrestingstatecerebellarcorticalconnectivityinbreastcancersurvivorswithcognitivecomplaintsafterchemotherapy AT sukkyoonan increasedrestingstatecerebellarcorticalconnectivityinbreastcancersurvivorswithcognitivecomplaintsafterchemotherapy AT keenamkoong increasedrestingstatecerebellarcorticalconnectivityinbreastcancersurvivorswithcognitivecomplaintsafterchemotherapy AT eunlee increasedrestingstatecerebellarcorticalconnectivityinbreastcancersurvivorswithcognitivecomplaintsafterchemotherapy
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Increased resting-state cerebellar-cortical connectivity in breast cancer survivors with cognitive complaints after chemotherapy

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