Coagulation in Lymphatic System

The lymphatic system maintains homeostasis of the internal environment between the cells in tissues and the blood circulation. The coagulation state of lymph is determined by conditions of coagulation factors and lymphatic vessels. Internal obliteration, external compression or abnormally increased...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wendi Zhang, Jiang Li, Jiangjiu Liang, Xiumei Qi, Jinghui Tian, Ju Liu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	coagulation lymphatic endothelium lymphatic thrombosis lymph lymphedema Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/bb158d2fa2bd4f2ea5a06d7685588d3b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bb158d2fa2bd4f2ea5a06d7685588d3b
record_format	dspace
spelling	oai:doaj.org-article:bb158d2fa2bd4f2ea5a06d7685588d3b2021-11-30T17:55:35ZCoagulation in Lymphatic System2297-055X10.3389/fcvm.2021.762648https://doaj.org/article/bb158d2fa2bd4f2ea5a06d7685588d3b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.762648/fullhttps://doaj.org/toc/2297-055XThe lymphatic system maintains homeostasis of the internal environment between the cells in tissues and the blood circulation. The coagulation state of lymph is determined by conditions of coagulation factors and lymphatic vessels. Internal obliteration, external compression or abnormally increased lymphatic pressure may predispose to localized lymphatic coagulation. In physiological conditions, an imbalance of antithrombin and thrombokinase reduces lymphatic thrombosis. However, the release of factor X by lymphatic endothelium injury may trigger coagulation casacade, causing blockage of lymphatic vessels and lymphedema. Heterogeneity of lymphatic vessels in various tissues may lead to distinct levels and patterns of coagulation in specific lymphatic vessels. The quantitative and qualitative measurement of clotting characteristic reveals longer time for clotting to occur in the lymph than in the blood. Cancer, infections, amyloidosis and lymph node dissection may trigger thrombosis in the lymphatic vessels. In contrast to venous or arterial thrombosis, lymphatic thrombosis has rarely been reported, and its actual prevalence is likely underestimated. In this review, we summarize the mechanisms of coagulation in lymphatic system, and discuss the lymphatic thrombosis-related diseases.Wendi ZhangWendi ZhangWendi ZhangJiang LiJiangjiu LiangXiumei QiJinghui TianJu LiuJu LiuFrontiers Media S.A.articlecoagulationlymphatic endotheliumlymphatic thrombosislymphlymphedemaDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	coagulation lymphatic endothelium lymphatic thrombosis lymph lymphedema Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	coagulation lymphatic endothelium lymphatic thrombosis lymph lymphedema Diseases of the circulatory (Cardiovascular) system RC666-701 Wendi Zhang Wendi Zhang Wendi Zhang Jiang Li Jiangjiu Liang Xiumei Qi Jinghui Tian Ju Liu Ju Liu Coagulation in Lymphatic System
description	The lymphatic system maintains homeostasis of the internal environment between the cells in tissues and the blood circulation. The coagulation state of lymph is determined by conditions of coagulation factors and lymphatic vessels. Internal obliteration, external compression or abnormally increased lymphatic pressure may predispose to localized lymphatic coagulation. In physiological conditions, an imbalance of antithrombin and thrombokinase reduces lymphatic thrombosis. However, the release of factor X by lymphatic endothelium injury may trigger coagulation casacade, causing blockage of lymphatic vessels and lymphedema. Heterogeneity of lymphatic vessels in various tissues may lead to distinct levels and patterns of coagulation in specific lymphatic vessels. The quantitative and qualitative measurement of clotting characteristic reveals longer time for clotting to occur in the lymph than in the blood. Cancer, infections, amyloidosis and lymph node dissection may trigger thrombosis in the lymphatic vessels. In contrast to venous or arterial thrombosis, lymphatic thrombosis has rarely been reported, and its actual prevalence is likely underestimated. In this review, we summarize the mechanisms of coagulation in lymphatic system, and discuss the lymphatic thrombosis-related diseases.
format	article
author	Wendi Zhang Wendi Zhang Wendi Zhang Jiang Li Jiangjiu Liang Xiumei Qi Jinghui Tian Ju Liu Ju Liu
author_facet	Wendi Zhang Wendi Zhang Wendi Zhang Jiang Li Jiangjiu Liang Xiumei Qi Jinghui Tian Ju Liu Ju Liu
author_sort	Wendi Zhang
title	Coagulation in Lymphatic System
title_short	Coagulation in Lymphatic System
title_full	Coagulation in Lymphatic System
title_fullStr	Coagulation in Lymphatic System
title_full_unstemmed	Coagulation in Lymphatic System
title_sort	coagulation in lymphatic system
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/bb158d2fa2bd4f2ea5a06d7685588d3b
work_keys_str_mv	AT wendizhang coagulationinlymphaticsystem AT wendizhang coagulationinlymphaticsystem AT wendizhang coagulationinlymphaticsystem AT jiangli coagulationinlymphaticsystem AT jiangjiuliang coagulationinlymphaticsystem AT xiumeiqi coagulationinlymphaticsystem AT jinghuitian coagulationinlymphaticsystem AT juliu coagulationinlymphaticsystem AT juliu coagulationinlymphaticsystem
_version_	1718406405219680256

Coagulation in Lymphatic System

Ejemplares similares