Evolutionary time-scale of the begomoviruses: evidence from integrated sequences in the Nicotiana genome.

Despite having single stranded DNA genomes that are replicated by host DNA polymerases, viruses in the family Geminiviridae are apparently evolving as rapidly as some RNA viruses. The observed substitution rates of geminiviruses in the genera Begomovirus and Mastrevirus are so high that the entire f...

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Autores principales:	Pierre Lefeuvre, Gordon W Harkins, Jean-Michel Lett, Rob W Briddon, Mark W Chase, Benoit Moury, Darren P Martin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bb16116cc1274a33bc3e8f66c1527181
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spelling	oai:doaj.org-article:bb16116cc1274a33bc3e8f66c15271812021-11-18T06:53:54ZEvolutionary time-scale of the begomoviruses: evidence from integrated sequences in the Nicotiana genome.1932-620310.1371/journal.pone.0019193https://doaj.org/article/bb16116cc1274a33bc3e8f66c15271812011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21603653/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Despite having single stranded DNA genomes that are replicated by host DNA polymerases, viruses in the family Geminiviridae are apparently evolving as rapidly as some RNA viruses. The observed substitution rates of geminiviruses in the genera Begomovirus and Mastrevirus are so high that the entire family could conceivably have originated less than a million years ago (MYA). However, the existence of geminivirus related DNA (GRD) integrated within the genomes of various Nicotiana species suggests that the geminiviruses probably originated >10 MYA. Some have even suggested that a distinct New-World (NW) lineage of begomoviruses may have arisen following the separation by continental drift of African and American proto-begomoviruses ∼110 MYA. We evaluate these various geminivirus origin hypotheses using Bayesian coalescent-based approaches to date firstly the Nicotiana GRD integration events, and then the divergence of the NW and Old-World (OW) begomoviruses. Besides rejecting the possibility of a<2 MYA OW-NW begomovirus split, we could also discount that it may have occurred concomitantly with the breakup of Gondwanaland 110 MYA. Although we could only confidently narrow the date of the split down to between 2 and 80 MYA, the most plausible (and best supported) date for the split is between 20 and 30 MYA--a time when global cooling ended the dispersal of temperate species between Asia and North America via the Beringian land bridge.Pierre LefeuvreGordon W HarkinsJean-Michel LettRob W BriddonMark W ChaseBenoit MouryDarren P MartinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 5, p e19193 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pierre Lefeuvre Gordon W Harkins Jean-Michel Lett Rob W Briddon Mark W Chase Benoit Moury Darren P Martin Evolutionary time-scale of the begomoviruses: evidence from integrated sequences in the Nicotiana genome.
description	Despite having single stranded DNA genomes that are replicated by host DNA polymerases, viruses in the family Geminiviridae are apparently evolving as rapidly as some RNA viruses. The observed substitution rates of geminiviruses in the genera Begomovirus and Mastrevirus are so high that the entire family could conceivably have originated less than a million years ago (MYA). However, the existence of geminivirus related DNA (GRD) integrated within the genomes of various Nicotiana species suggests that the geminiviruses probably originated >10 MYA. Some have even suggested that a distinct New-World (NW) lineage of begomoviruses may have arisen following the separation by continental drift of African and American proto-begomoviruses ∼110 MYA. We evaluate these various geminivirus origin hypotheses using Bayesian coalescent-based approaches to date firstly the Nicotiana GRD integration events, and then the divergence of the NW and Old-World (OW) begomoviruses. Besides rejecting the possibility of a<2 MYA OW-NW begomovirus split, we could also discount that it may have occurred concomitantly with the breakup of Gondwanaland 110 MYA. Although we could only confidently narrow the date of the split down to between 2 and 80 MYA, the most plausible (and best supported) date for the split is between 20 and 30 MYA--a time when global cooling ended the dispersal of temperate species between Asia and North America via the Beringian land bridge.
format	article
author	Pierre Lefeuvre Gordon W Harkins Jean-Michel Lett Rob W Briddon Mark W Chase Benoit Moury Darren P Martin
author_facet	Pierre Lefeuvre Gordon W Harkins Jean-Michel Lett Rob W Briddon Mark W Chase Benoit Moury Darren P Martin
author_sort	Pierre Lefeuvre
title	Evolutionary time-scale of the begomoviruses: evidence from integrated sequences in the Nicotiana genome.
title_short	Evolutionary time-scale of the begomoviruses: evidence from integrated sequences in the Nicotiana genome.
title_full	Evolutionary time-scale of the begomoviruses: evidence from integrated sequences in the Nicotiana genome.
title_fullStr	Evolutionary time-scale of the begomoviruses: evidence from integrated sequences in the Nicotiana genome.
title_full_unstemmed	Evolutionary time-scale of the begomoviruses: evidence from integrated sequences in the Nicotiana genome.
title_sort	evolutionary time-scale of the begomoviruses: evidence from integrated sequences in the nicotiana genome.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/bb16116cc1274a33bc3e8f66c1527181
work_keys_str_mv	AT pierrelefeuvre evolutionarytimescaleofthebegomovirusesevidencefromintegratedsequencesinthenicotianagenome AT gordonwharkins evolutionarytimescaleofthebegomovirusesevidencefromintegratedsequencesinthenicotianagenome AT jeanmichellett evolutionarytimescaleofthebegomovirusesevidencefromintegratedsequencesinthenicotianagenome AT robwbriddon evolutionarytimescaleofthebegomovirusesevidencefromintegratedsequencesinthenicotianagenome AT markwchase evolutionarytimescaleofthebegomovirusesevidencefromintegratedsequencesinthenicotianagenome AT benoitmoury evolutionarytimescaleofthebegomovirusesevidencefromintegratedsequencesinthenicotianagenome AT darrenpmartin evolutionarytimescaleofthebegomovirusesevidencefromintegratedsequencesinthenicotianagenome
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Evolutionary time-scale of the begomoviruses: evidence from integrated sequences in the Nicotiana genome.

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