Fungal species in endodontic infections: A systematic review and meta-analysis.

Fungal infections are common on oral mucosae, but their role in other oral sites is ill defined. Over the last few decades, numerous studies have reported the presence of fungi, particularly Candida species in endodontic infections, albeit in relatively small numbers in comparison to its predominant...

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Autores principales:	Alice Alberti, Stefano Corbella, Silvio Taschieri, Luca Francetti, Kausar Sadia Fakhruddin, Lakshman Perera Samaranayake
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bb1846d4d0d64bb5b94028ff9093df0b
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spelling	oai:doaj.org-article:bb1846d4d0d64bb5b94028ff9093df0b2021-12-02T20:06:33ZFungal species in endodontic infections: A systematic review and meta-analysis.1932-620310.1371/journal.pone.0255003https://doaj.org/article/bb1846d4d0d64bb5b94028ff9093df0b2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255003https://doaj.org/toc/1932-6203Fungal infections are common on oral mucosae, but their role in other oral sites is ill defined. Over the last few decades, numerous studies have reported the presence of fungi, particularly Candida species in endodontic infections, albeit in relatively small numbers in comparison to its predominant anaerobic bacteriome. Here, we review the fungal biome of primary and secondary endodontic infections, with particular reference to the prevalence and behavior of Candida species. Meta-analysis of the available data from a total of 39 studies fitting the inclusion criteria, indicate the overall weighted mean prevalence (WMP) of fungal species in endodontic infections to be 9.11% (from a cumulative total of 2003 samples), with 9.0% in primary (n = 1341), and 9.3% in secondary infections (n = 662). Nevertheless, WMP for fungi in primary and secondary infections which were 6.3% and 7.5% for culture-based studies, increased to 12.5% and 16.0% in molecular studies, respectively. The most prevalent fungal species was Candida spp. The high heterogeneity in the reported fungal prevalence suggests the need for standardized sampling, and speciation methods. The advent of the new molecular biological analytical platforms, such as the next generation sequencing (NGS), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF), that enables identification and quantitation of a broad spectrum of hitherto unknown organisms in endodontic infections should radically alter our understanding of the endodontic mycobiome in the future. Candida spp. appear to be co-pathogens with bacteria in approximately one in ten patients with endodontic infections. Hence, clinicians should comprehend the importance and the role of fungi in endodontic infections and be cognizant of the need to eradicate both bacteria and fungi for successful therapy.Alice AlbertiStefano CorbellaSilvio TaschieriLuca FrancettiKausar Sadia FakhruddinLakshman Perera SamaranayakePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0255003 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alice Alberti Stefano Corbella Silvio Taschieri Luca Francetti Kausar Sadia Fakhruddin Lakshman Perera Samaranayake Fungal species in endodontic infections: A systematic review and meta-analysis.
description	Fungal infections are common on oral mucosae, but their role in other oral sites is ill defined. Over the last few decades, numerous studies have reported the presence of fungi, particularly Candida species in endodontic infections, albeit in relatively small numbers in comparison to its predominant anaerobic bacteriome. Here, we review the fungal biome of primary and secondary endodontic infections, with particular reference to the prevalence and behavior of Candida species. Meta-analysis of the available data from a total of 39 studies fitting the inclusion criteria, indicate the overall weighted mean prevalence (WMP) of fungal species in endodontic infections to be 9.11% (from a cumulative total of 2003 samples), with 9.0% in primary (n = 1341), and 9.3% in secondary infections (n = 662). Nevertheless, WMP for fungi in primary and secondary infections which were 6.3% and 7.5% for culture-based studies, increased to 12.5% and 16.0% in molecular studies, respectively. The most prevalent fungal species was Candida spp. The high heterogeneity in the reported fungal prevalence suggests the need for standardized sampling, and speciation methods. The advent of the new molecular biological analytical platforms, such as the next generation sequencing (NGS), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF), that enables identification and quantitation of a broad spectrum of hitherto unknown organisms in endodontic infections should radically alter our understanding of the endodontic mycobiome in the future. Candida spp. appear to be co-pathogens with bacteria in approximately one in ten patients with endodontic infections. Hence, clinicians should comprehend the importance and the role of fungi in endodontic infections and be cognizant of the need to eradicate both bacteria and fungi for successful therapy.
format	article
author	Alice Alberti Stefano Corbella Silvio Taschieri Luca Francetti Kausar Sadia Fakhruddin Lakshman Perera Samaranayake
author_facet	Alice Alberti Stefano Corbella Silvio Taschieri Luca Francetti Kausar Sadia Fakhruddin Lakshman Perera Samaranayake
author_sort	Alice Alberti
title	Fungal species in endodontic infections: A systematic review and meta-analysis.
title_short	Fungal species in endodontic infections: A systematic review and meta-analysis.
title_full	Fungal species in endodontic infections: A systematic review and meta-analysis.
title_fullStr	Fungal species in endodontic infections: A systematic review and meta-analysis.
title_full_unstemmed	Fungal species in endodontic infections: A systematic review and meta-analysis.
title_sort	fungal species in endodontic infections: a systematic review and meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/bb1846d4d0d64bb5b94028ff9093df0b
work_keys_str_mv	AT alicealberti fungalspeciesinendodonticinfectionsasystematicreviewandmetaanalysis AT stefanocorbella fungalspeciesinendodonticinfectionsasystematicreviewandmetaanalysis AT silviotaschieri fungalspeciesinendodonticinfectionsasystematicreviewandmetaanalysis AT lucafrancetti fungalspeciesinendodonticinfectionsasystematicreviewandmetaanalysis AT kausarsadiafakhruddin fungalspeciesinendodonticinfectionsasystematicreviewandmetaanalysis AT lakshmanpererasamaranayake fungalspeciesinendodonticinfectionsasystematicreviewandmetaanalysis
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Fungal species in endodontic infections: A systematic review and meta-analysis.

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