The Par3 polarity protein is an exocyst receptor essential for mammary cell survival

The exocyst delivers basolateral proteins from the secretory pathway to the plasma membrane of epithelial cells close to tight junctions. Here the authors show that Par3 acts as a docking site for the exocyst to regulate polarized delivery of basolateral proteins and this is essential to prevent apo...

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Main Authors:	Syed Mukhtar Ahmed, Ian G. Macara
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/bb1bc86d76a448d29d257522799a1655
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spelling	oai:doaj.org-article:bb1bc86d76a448d29d257522799a16552021-12-02T16:51:48ZThe Par3 polarity protein is an exocyst receptor essential for mammary cell survival10.1038/ncomms148672041-1723https://doaj.org/article/bb1bc86d76a448d29d257522799a16552017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14867https://doaj.org/toc/2041-1723The exocyst delivers basolateral proteins from the secretory pathway to the plasma membrane of epithelial cells close to tight junctions. Here the authors show that Par3 acts as a docking site for the exocyst to regulate polarized delivery of basolateral proteins and this is essential to prevent apoptosis and promote mammary cell survival.Syed Mukhtar AhmedIan G. MacaraNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Syed Mukhtar Ahmed Ian G. Macara The Par3 polarity protein is an exocyst receptor essential for mammary cell survival
description	The exocyst delivers basolateral proteins from the secretory pathway to the plasma membrane of epithelial cells close to tight junctions. Here the authors show that Par3 acts as a docking site for the exocyst to regulate polarized delivery of basolateral proteins and this is essential to prevent apoptosis and promote mammary cell survival.
format	article
author	Syed Mukhtar Ahmed Ian G. Macara
author_facet	Syed Mukhtar Ahmed Ian G. Macara
author_sort	Syed Mukhtar Ahmed
title	The Par3 polarity protein is an exocyst receptor essential for mammary cell survival
title_short	The Par3 polarity protein is an exocyst receptor essential for mammary cell survival
title_full	The Par3 polarity protein is an exocyst receptor essential for mammary cell survival
title_fullStr	The Par3 polarity protein is an exocyst receptor essential for mammary cell survival
title_full_unstemmed	The Par3 polarity protein is an exocyst receptor essential for mammary cell survival
title_sort	par3 polarity protein is an exocyst receptor essential for mammary cell survival
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bb1bc86d76a448d29d257522799a1655
work_keys_str_mv	AT syedmukhtarahmed thepar3polarityproteinisanexocystreceptoressentialformammarycellsurvival AT iangmacara thepar3polarityproteinisanexocystreceptoressentialformammarycellsurvival AT syedmukhtarahmed par3polarityproteinisanexocystreceptoressentialformammarycellsurvival AT iangmacara par3polarityproteinisanexocystreceptoressentialformammarycellsurvival
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The Par3 polarity protein is an exocyst receptor essential for mammary cell survival

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