Markers of neurodevelopmental impairments in early-onset psychosis

Markers of neurodevelopmental impairments in early-onset psychosis

Maria Giuseppina Petruzzelli,1 Lucia Margari,1 Francesco Craig,1 Maria Gloria Campa,1 Domenico Martinelli,2 Adriana Pastore,3 Marta Simone,1 Francesco Margari3 1Child and Adolescence Neuropsychiatry Unit, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University &...

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Autores principales: Petruzzelli MG, Margari L, Craig F, Campa MG, Martinelli D, Pastore A, Simone M, Margari F
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
Materias:
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/bb1d6cfacdf54227b85dc8a052af1cd5
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spelling oai:doaj.org-article:bb1d6cfacdf54227b85dc8a052af1cd52021-12-02T02:49:15ZMarkers of neurodevelopmental impairments in early-onset psychosis1178-2021https://doaj.org/article/bb1d6cfacdf54227b85dc8a052af1cd52015-07-01T00:00:00Zhttp://www.dovepress.com/markers-of-neurodevelopmental-impairments-innbspearly-onset-psychosis-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Maria Giuseppina Petruzzelli,1 Lucia Margari,1 Francesco Craig,1 Maria Gloria Campa,1 Domenico Martinelli,2 Adriana Pastore,3 Marta Simone,1 Francesco Margari3 1Child and Adolescence Neuropsychiatry Unit, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University “Aldo Moro” of Bari, 2Department of Medical and Surgical Sciences; University of Foggia, Foggia, 3Psychiatry Unit, Department of Basic Medical Sciences, Neuroscience and Sense Organ, University “Aldo Moro” of Bari, Bari, Italy Background: The aim of this study was to assess the association between the clinical and neurobiological markers of neurodevelopmental impairments and early-onset schizophrenia spectrum psychosis. Methods: A sample of 36 patients with early-onset schizophrenia spectrum psychosis was compared to a control sample of 36 patients with migraine. We assessed early childhood neurodevelopmental milestones using a modified version of the General Developmental Scale, general intellectual ability using the Wechsler Intelligence Scale for Children–Revised or Leiter International Performance Scale–Revised for patients with speech and language abnormalities, and neurological soft signs with specific regard to subtle motor impairment. Results: Subjects with early-onset psychosis had a higher rate of impaired social development (P=0.001), learning difficulties (P=0.04), enuresis (P=0.0008), a lower intelligence quotient (P<0.001), and subtle motor impairments (P=0.005) than control subjects. Conclusion: We suggest that neurodevelopment in early-onset psychosis is characterized by a global impairment of functional and adaptive skills that manifests from early childhood, rather than a delay or limitation in language and motor development. The current evidence is based on a small sample and should be investigated in larger samples in future research. Keywords: early-onset psychosis, early-onset schizophrenia, neurodevelopment, social cognition, intellectual disabilitiesPetruzzelli MGMargari LCraig FCampa MGMartinelli DPastore ASimone MMargari FDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 1793-1798 (2015)
institution DOAJ
collection DOAJ
language EN
topic Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Petruzzelli MG
Margari L
Craig F
Campa MG
Martinelli D
Pastore A
Simone M
Margari F
Markers of neurodevelopmental impairments in early-onset psychosis
description Maria Giuseppina Petruzzelli,1 Lucia Margari,1 Francesco Craig,1 Maria Gloria Campa,1 Domenico Martinelli,2 Adriana Pastore,3 Marta Simone,1 Francesco Margari3 1Child and Adolescence Neuropsychiatry Unit, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University “Aldo Moro” of Bari, 2Department of Medical and Surgical Sciences; University of Foggia, Foggia, 3Psychiatry Unit, Department of Basic Medical Sciences, Neuroscience and Sense Organ, University “Aldo Moro” of Bari, Bari, Italy Background: The aim of this study was to assess the association between the clinical and neurobiological markers of neurodevelopmental impairments and early-onset schizophrenia spectrum psychosis. Methods: A sample of 36 patients with early-onset schizophrenia spectrum psychosis was compared to a control sample of 36 patients with migraine. We assessed early childhood neurodevelopmental milestones using a modified version of the General Developmental Scale, general intellectual ability using the Wechsler Intelligence Scale for Children–Revised or Leiter International Performance Scale–Revised for patients with speech and language abnormalities, and neurological soft signs with specific regard to subtle motor impairment. Results: Subjects with early-onset psychosis had a higher rate of impaired social development (P=0.001), learning difficulties (P=0.04), enuresis (P=0.0008), a lower intelligence quotient (P<0.001), and subtle motor impairments (P=0.005) than control subjects. Conclusion: We suggest that neurodevelopment in early-onset psychosis is characterized by a global impairment of functional and adaptive skills that manifests from early childhood, rather than a delay or limitation in language and motor development. The current evidence is based on a small sample and should be investigated in larger samples in future research. Keywords: early-onset psychosis, early-onset schizophrenia, neurodevelopment, social cognition, intellectual disabilities
format article
author Petruzzelli MG
Margari L
Craig F
Campa MG
Martinelli D
Pastore A
Simone M
Margari F
author_facet Petruzzelli MG
Margari L
Craig F
Campa MG
Martinelli D
Pastore A
Simone M
Margari F
author_sort Petruzzelli MG
title Markers of neurodevelopmental impairments in early-onset psychosis
title_short Markers of neurodevelopmental impairments in early-onset psychosis
title_full Markers of neurodevelopmental impairments in early-onset psychosis
title_fullStr Markers of neurodevelopmental impairments in early-onset psychosis
title_full_unstemmed Markers of neurodevelopmental impairments in early-onset psychosis
title_sort markers of neurodevelopmental impairments in early-onset psychosis
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/bb1d6cfacdf54227b85dc8a052af1cd5
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