LEVELS OF TUMOR NECROSIS FACTOR ALPHA IN PATIENTS WITH ISCHEMIC STROKE

Ischemic stroke is the most common form of brain stroke. It is associated with functional changes of various blood and bone marrow cell populations, altered release of various cytokines, chemokines, etc. There are conflicting data about serum and plasma TNFα levels in acute ischemic stroke.We have e...

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Autores principales:	I. A. Prilutskaya, Yu. Ya. Kryuk
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	tumor necrosis factor α ischemic stroke cytokine thrombosis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/bb1f03e6817546a58e5d3dd68ce70cdf
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spelling	oai:doaj.org-article:bb1f03e6817546a58e5d3dd68ce70cdf2021-11-18T08:03:48ZLEVELS OF TUMOR NECROSIS FACTOR ALPHA IN PATIENTS WITH ISCHEMIC STROKE1563-06252313-741X10.15789/1563-0625-2019-4-755-764https://doaj.org/article/bb1f03e6817546a58e5d3dd68ce70cdf2019-10-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1654https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XIschemic stroke is the most common form of brain stroke. It is associated with functional changes of various blood and bone marrow cell populations, altered release of various cytokines, chemokines, etc. There are conflicting data about serum and plasma TNFα levels in acute ischemic stroke.We have examined 21 patients with a diagnosis of ischemic stroke treated at the hospital. The severity of ischemic stroke was evaluated by neurologists, in accordance with NIHSS criteria at admission and at discharge. In the patients with ischemic stroke, we have found a significantly increased serum concentration of tumor necrosis factor-α (p < 0.001), as compared with healthy individuals. The highest concentrations of this marker were recorded on days 1 and 3 of the disease, being significant at p < 0.001 and p= 0.003, respectively, then decreasing by day 14, however, not reaching, the levels of control group. It should be noted that, among patients with ischemic stroke, there is a significantly (p < 0.001) increased proportion of individuals with high serum concentrations (>10 pg/ml) of this cytokine, i.e., 76.2±9.3% on day 1 of the disease.To statistically evaluate the individual differences of the patients’ dynamics, they were divided into subgroups, depending on the level of TNFα on the 1st day of hospitalization, using a discriminant analysis with estimation of a classification matrix. The correlation analysis showed numerous strongly positive correlations between TNFα levels on the 1st and 3rd days, as well as between similar indexes on the 1st and 14th days. A correlation between TNFα concentrations on the 3rd and 14th day was also found (r = 0.711; p < 0.01). Also, positive correlation in various periods of observation was established between the absolute levels of cytokine and differences in their concentration changes. The level of tumor necrosis factor-alpha on the first and third day of hospitalization did positively correlate (respectively, r = 0.503, p < 0.01; r = 0.411, p < 0.01) with the volume of the ischemic lesion according neuroimaging methods research. The volume of the ischemic focus was positively correlated with the difference in the concentration of TNFα on days 1-3 and 1-14 (respectively, r = 0.425, p < 0.01; r = 0.507, p < 0.01).The results of our study show a necessity for measuring TNFα levels at admission, in order to plan treatment in these groups of patients, especially in cases of increase or insufficient decrease in TNFα recorded on the 3rd day of therapy.I. A. PrilutskayaYu. Ya. KryukSPb RAACIarticletumor necrosis factor αischemic strokecytokinethrombosisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 4, Pp 755-764 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	tumor necrosis factor α ischemic stroke cytokine thrombosis Immunologic diseases. Allergy RC581-607
spellingShingle	tumor necrosis factor α ischemic stroke cytokine thrombosis Immunologic diseases. Allergy RC581-607 I. A. Prilutskaya Yu. Ya. Kryuk LEVELS OF TUMOR NECROSIS FACTOR ALPHA IN PATIENTS WITH ISCHEMIC STROKE
description	Ischemic stroke is the most common form of brain stroke. It is associated with functional changes of various blood and bone marrow cell populations, altered release of various cytokines, chemokines, etc. There are conflicting data about serum and plasma TNFα levels in acute ischemic stroke.We have examined 21 patients with a diagnosis of ischemic stroke treated at the hospital. The severity of ischemic stroke was evaluated by neurologists, in accordance with NIHSS criteria at admission and at discharge. In the patients with ischemic stroke, we have found a significantly increased serum concentration of tumor necrosis factor-α (p < 0.001), as compared with healthy individuals. The highest concentrations of this marker were recorded on days 1 and 3 of the disease, being significant at p < 0.001 and p= 0.003, respectively, then decreasing by day 14, however, not reaching, the levels of control group. It should be noted that, among patients with ischemic stroke, there is a significantly (p < 0.001) increased proportion of individuals with high serum concentrations (>10 pg/ml) of this cytokine, i.e., 76.2±9.3% on day 1 of the disease.To statistically evaluate the individual differences of the patients’ dynamics, they were divided into subgroups, depending on the level of TNFα on the 1st day of hospitalization, using a discriminant analysis with estimation of a classification matrix. The correlation analysis showed numerous strongly positive correlations between TNFα levels on the 1st and 3rd days, as well as between similar indexes on the 1st and 14th days. A correlation between TNFα concentrations on the 3rd and 14th day was also found (r = 0.711; p < 0.01). Also, positive correlation in various periods of observation was established between the absolute levels of cytokine and differences in their concentration changes. The level of tumor necrosis factor-alpha on the first and third day of hospitalization did positively correlate (respectively, r = 0.503, p < 0.01; r = 0.411, p < 0.01) with the volume of the ischemic lesion according neuroimaging methods research. The volume of the ischemic focus was positively correlated with the difference in the concentration of TNFα on days 1-3 and 1-14 (respectively, r = 0.425, p < 0.01; r = 0.507, p < 0.01).The results of our study show a necessity for measuring TNFα levels at admission, in order to plan treatment in these groups of patients, especially in cases of increase or insufficient decrease in TNFα recorded on the 3rd day of therapy.
format	article
author	I. A. Prilutskaya Yu. Ya. Kryuk
author_facet	I. A. Prilutskaya Yu. Ya. Kryuk
author_sort	I. A. Prilutskaya
title	LEVELS OF TUMOR NECROSIS FACTOR ALPHA IN PATIENTS WITH ISCHEMIC STROKE
title_short	LEVELS OF TUMOR NECROSIS FACTOR ALPHA IN PATIENTS WITH ISCHEMIC STROKE
title_full	LEVELS OF TUMOR NECROSIS FACTOR ALPHA IN PATIENTS WITH ISCHEMIC STROKE
title_fullStr	LEVELS OF TUMOR NECROSIS FACTOR ALPHA IN PATIENTS WITH ISCHEMIC STROKE
title_full_unstemmed	LEVELS OF TUMOR NECROSIS FACTOR ALPHA IN PATIENTS WITH ISCHEMIC STROKE
title_sort	levels of tumor necrosis factor alpha in patients with ischemic stroke
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/bb1f03e6817546a58e5d3dd68ce70cdf
work_keys_str_mv	AT iaprilutskaya levelsoftumornecrosisfactoralphainpatientswithischemicstroke AT yuyakryuk levelsoftumornecrosisfactoralphainpatientswithischemicstroke
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LEVELS OF TUMOR NECROSIS FACTOR ALPHA IN PATIENTS WITH ISCHEMIC STROKE

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