Deubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress

Ubiquitination of misfolded proteins usually results in protein degradation. Here, the authors show that two deubiquitinases—enzymes that remove ubiquitin—are required for the proteasomal degradation of misfolded proteins in response to heat-shock in yeast.

Guardado en:

Detalles Bibliográficos
Autores principales:	Nancy N. Fang, Mang Zhu, Amalia Rose, Kuen-Phon Wu, Thibault Mayor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bb1f6b2fea944600b8079e5c104d5d89
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bb1f6b2fea944600b8079e5c104d5d89
record_format	dspace
spelling	oai:doaj.org-article:bb1f6b2fea944600b8079e5c104d5d892021-12-02T17:32:20ZDeubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress10.1038/ncomms129072041-1723https://doaj.org/article/bb1f6b2fea944600b8079e5c104d5d892016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12907https://doaj.org/toc/2041-1723Ubiquitination of misfolded proteins usually results in protein degradation. Here, the authors show that two deubiquitinases—enzymes that remove ubiquitin—are required for the proteasomal degradation of misfolded proteins in response to heat-shock in yeast.Nancy N. FangMang ZhuAmalia RoseKuen-Phon WuThibault MayorNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nancy N. Fang Mang Zhu Amalia Rose Kuen-Phon Wu Thibault Mayor Deubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress
description	Ubiquitination of misfolded proteins usually results in protein degradation. Here, the authors show that two deubiquitinases—enzymes that remove ubiquitin—are required for the proteasomal degradation of misfolded proteins in response to heat-shock in yeast.
format	article
author	Nancy N. Fang Mang Zhu Amalia Rose Kuen-Phon Wu Thibault Mayor
author_facet	Nancy N. Fang Mang Zhu Amalia Rose Kuen-Phon Wu Thibault Mayor
author_sort	Nancy N. Fang
title	Deubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress
title_short	Deubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress
title_full	Deubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress
title_fullStr	Deubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress
title_full_unstemmed	Deubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress
title_sort	deubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/bb1f6b2fea944600b8079e5c104d5d89
work_keys_str_mv	AT nancynfang deubiquitinaseactivityisrequiredfortheproteasomaldegradationofmisfoldedcytosolicproteinsuponheatstress AT mangzhu deubiquitinaseactivityisrequiredfortheproteasomaldegradationofmisfoldedcytosolicproteinsuponheatstress AT amaliarose deubiquitinaseactivityisrequiredfortheproteasomaldegradationofmisfoldedcytosolicproteinsuponheatstress AT kuenphonwu deubiquitinaseactivityisrequiredfortheproteasomaldegradationofmisfoldedcytosolicproteinsuponheatstress AT thibaultmayor deubiquitinaseactivityisrequiredfortheproteasomaldegradationofmisfoldedcytosolicproteinsuponheatstress
_version_	1718380332285165568

Deubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress

Ejemplares similares