Impaired cerebro-cerebellar white matter connectivity and its associations with cognitive function in patients with schizophrenia

Abstract Schizophrenia is a complex brain disorder of unknown etiology. Based on the notion of “cognitive dysmetria,” we aimed to investigate aberrations in structural white matter (WM) connectivity that links the cerebellum to cognitive dysfunction in patients with schizophrenia. A total of 112 par...

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Autores principales:	Sung Eun Kim, Sungcheol Jung, Gyhye Sung, Minji Bang, Sang-Hyuk Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/bb25cf1725a34c9b8c09a2acb5d58449
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spelling	oai:doaj.org-article:bb25cf1725a34c9b8c09a2acb5d584492021-12-02T15:08:38ZImpaired cerebro-cerebellar white matter connectivity and its associations with cognitive function in patients with schizophrenia10.1038/s41537-021-00169-w2334-265Xhttps://doaj.org/article/bb25cf1725a34c9b8c09a2acb5d584492021-08-01T00:00:00Zhttps://doi.org/10.1038/s41537-021-00169-whttps://doaj.org/toc/2334-265XAbstract Schizophrenia is a complex brain disorder of unknown etiology. Based on the notion of “cognitive dysmetria,” we aimed to investigate aberrations in structural white matter (WM) connectivity that links the cerebellum to cognitive dysfunction in patients with schizophrenia. A total of 112 participants (65 patients with schizophrenia and 47 healthy controls [HCs]) were enrolled and underwent diffusion tensor imaging. Between-group voxel-wise comparisons of cerebellar WM regions (superior/middle [MCP]/inferior cerebellar peduncle and pontine crossing fibers) were performed using Tract-Based Spatial Statistics. Cognitive function was assessed using the Trail Making Test Part A/B (TMT-A/B), Wisconsin Card Sorting Test (WCST), and Rey-Kim Memory Test in 46 participants with schizophrenia. WM connectivity, measured as fractional anisotropy (FA), was significantly lower in the MCP in participants with schizophrenia than in HCs. The mean FAs extracted from the significant MCP cluster were inversely correlated with poorer cognitive performance, particularly longer time to complete the TMB-B (r = 0.559, p < 0.001) and more total errors in the WCST (r = 0.442, p = 0.003). Our findings suggest that aberrant cerebro-cerebellar communication due to disrupted WM connectivity may contribute to cognitive impairments, a core characteristic of schizophrenia. Our results may expand our understanding of the neurobiology of schizophrenia based on the cerebro-cerebellar interconnectivity of the brain.Sung Eun KimSungcheol JungGyhye SungMinji BangSang-Hyuk LeeNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Sung Eun Kim Sungcheol Jung Gyhye Sung Minji Bang Sang-Hyuk Lee Impaired cerebro-cerebellar white matter connectivity and its associations with cognitive function in patients with schizophrenia
description	Abstract Schizophrenia is a complex brain disorder of unknown etiology. Based on the notion of “cognitive dysmetria,” we aimed to investigate aberrations in structural white matter (WM) connectivity that links the cerebellum to cognitive dysfunction in patients with schizophrenia. A total of 112 participants (65 patients with schizophrenia and 47 healthy controls [HCs]) were enrolled and underwent diffusion tensor imaging. Between-group voxel-wise comparisons of cerebellar WM regions (superior/middle [MCP]/inferior cerebellar peduncle and pontine crossing fibers) were performed using Tract-Based Spatial Statistics. Cognitive function was assessed using the Trail Making Test Part A/B (TMT-A/B), Wisconsin Card Sorting Test (WCST), and Rey-Kim Memory Test in 46 participants with schizophrenia. WM connectivity, measured as fractional anisotropy (FA), was significantly lower in the MCP in participants with schizophrenia than in HCs. The mean FAs extracted from the significant MCP cluster were inversely correlated with poorer cognitive performance, particularly longer time to complete the TMB-B (r = 0.559, p < 0.001) and more total errors in the WCST (r = 0.442, p = 0.003). Our findings suggest that aberrant cerebro-cerebellar communication due to disrupted WM connectivity may contribute to cognitive impairments, a core characteristic of schizophrenia. Our results may expand our understanding of the neurobiology of schizophrenia based on the cerebro-cerebellar interconnectivity of the brain.
format	article
author	Sung Eun Kim Sungcheol Jung Gyhye Sung Minji Bang Sang-Hyuk Lee
author_facet	Sung Eun Kim Sungcheol Jung Gyhye Sung Minji Bang Sang-Hyuk Lee
author_sort	Sung Eun Kim
title	Impaired cerebro-cerebellar white matter connectivity and its associations with cognitive function in patients with schizophrenia
title_short	Impaired cerebro-cerebellar white matter connectivity and its associations with cognitive function in patients with schizophrenia
title_full	Impaired cerebro-cerebellar white matter connectivity and its associations with cognitive function in patients with schizophrenia
title_fullStr	Impaired cerebro-cerebellar white matter connectivity and its associations with cognitive function in patients with schizophrenia
title_full_unstemmed	Impaired cerebro-cerebellar white matter connectivity and its associations with cognitive function in patients with schizophrenia
title_sort	impaired cerebro-cerebellar white matter connectivity and its associations with cognitive function in patients with schizophrenia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bb25cf1725a34c9b8c09a2acb5d58449
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Impaired cerebro-cerebellar white matter connectivity and its associations with cognitive function in patients with schizophrenia

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