A clinical staging proposal of the disease course over time in non-severe patients with coronavirus disease 2019

Abstract Information on the clinical staging of coronavirus disease 2019 (COVID-19) is still limited. This study aimed to propose a clinical staging proposal of the disease course in non-severe patients with COVID-19. In this retrospective study, 108 non-severe patients with COVID-19 were grouped ac...

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Autores principales:	Yiting Lin, Yiqun Wu, Ping Zhong, Bingbo Hou, Jielan Liu, Yingying Chen, Jiajun Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bb2aa8322fb947a69c62d5abb6f0863e
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spelling	oai:doaj.org-article:bb2aa8322fb947a69c62d5abb6f0863e2021-12-02T16:51:26ZA clinical staging proposal of the disease course over time in non-severe patients with coronavirus disease 201910.1038/s41598-021-90111-y2045-2322https://doaj.org/article/bb2aa8322fb947a69c62d5abb6f0863e2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90111-yhttps://doaj.org/toc/2045-2322Abstract Information on the clinical staging of coronavirus disease 2019 (COVID-19) is still limited. This study aimed to propose a clinical staging proposal of the disease course in non-severe patients with COVID-19. In this retrospective study, 108 non-severe patients with COVID-19 were grouped according to the duration from symptoms onset to hospital admission: ≤ 1 week, > 1 to 2 weeks, > 2 to 3 weeks, > 3 to 5 weeks, respectively. The dynamic changes of clinical signs were profiled across the four groups. A clinical staging proposal of the disease course over time was proposed from the perspective of the interaction between the virus and host. The prodromal phase, characterized by pneumonia, significant lymphopenia, and slightly elevated inflammatory markers, occurred in the first week after symptoms onset. In the second week, all the hematological and inflammatory markers were at the peak or bottom. Meanwhile, progressive pneumonia as well as the secondary damage of other organs (e.g. cardiac damage, coagulopathy, etc.) was significant during this period, making the disease progress into the apparent manifestation phase. In the third week, the improvement of the majority of clinical signs accompanied by a relatively high degree of inflammatory response defined the remission phase. After 3 weeks, patients were in the convalescent phase, in which all the indicators were maintained at a relatively normal level. We concluded that the disease course over time in non-severe patients with COVID-19 could be divided into four phases: the prodromal phase (in the first week), the apparent manifestation phase (in the second week), the remission phase (in the third week), and the convalescent phase (after 3 weeks), respectively. In clinical practice, tailored therapies should be considered seriously in different stages of the disease course.Yiting LinYiqun WuPing ZhongBingbo HouJielan LiuYingying ChenJiajun LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yiting Lin Yiqun Wu Ping Zhong Bingbo Hou Jielan Liu Yingying Chen Jiajun Liu A clinical staging proposal of the disease course over time in non-severe patients with coronavirus disease 2019
description	Abstract Information on the clinical staging of coronavirus disease 2019 (COVID-19) is still limited. This study aimed to propose a clinical staging proposal of the disease course in non-severe patients with COVID-19. In this retrospective study, 108 non-severe patients with COVID-19 were grouped according to the duration from symptoms onset to hospital admission: ≤ 1 week, > 1 to 2 weeks, > 2 to 3 weeks, > 3 to 5 weeks, respectively. The dynamic changes of clinical signs were profiled across the four groups. A clinical staging proposal of the disease course over time was proposed from the perspective of the interaction between the virus and host. The prodromal phase, characterized by pneumonia, significant lymphopenia, and slightly elevated inflammatory markers, occurred in the first week after symptoms onset. In the second week, all the hematological and inflammatory markers were at the peak or bottom. Meanwhile, progressive pneumonia as well as the secondary damage of other organs (e.g. cardiac damage, coagulopathy, etc.) was significant during this period, making the disease progress into the apparent manifestation phase. In the third week, the improvement of the majority of clinical signs accompanied by a relatively high degree of inflammatory response defined the remission phase. After 3 weeks, patients were in the convalescent phase, in which all the indicators were maintained at a relatively normal level. We concluded that the disease course over time in non-severe patients with COVID-19 could be divided into four phases: the prodromal phase (in the first week), the apparent manifestation phase (in the second week), the remission phase (in the third week), and the convalescent phase (after 3 weeks), respectively. In clinical practice, tailored therapies should be considered seriously in different stages of the disease course.
format	article
author	Yiting Lin Yiqun Wu Ping Zhong Bingbo Hou Jielan Liu Yingying Chen Jiajun Liu
author_facet	Yiting Lin Yiqun Wu Ping Zhong Bingbo Hou Jielan Liu Yingying Chen Jiajun Liu
author_sort	Yiting Lin
title	A clinical staging proposal of the disease course over time in non-severe patients with coronavirus disease 2019
title_short	A clinical staging proposal of the disease course over time in non-severe patients with coronavirus disease 2019
title_full	A clinical staging proposal of the disease course over time in non-severe patients with coronavirus disease 2019
title_fullStr	A clinical staging proposal of the disease course over time in non-severe patients with coronavirus disease 2019
title_full_unstemmed	A clinical staging proposal of the disease course over time in non-severe patients with coronavirus disease 2019
title_sort	clinical staging proposal of the disease course over time in non-severe patients with coronavirus disease 2019
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bb2aa8322fb947a69c62d5abb6f0863e
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A clinical staging proposal of the disease course over time in non-severe patients with coronavirus disease 2019

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