Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation

Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation

Reham Mokhtar Aman, Irhan Ibrahim Abu Hashim, Mahasen Mohamed Meshali Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura 35516, EgyptCorrespondence: Irhan Ibrahim Abu HashimDepartment of Pharmaceutics, Faculty of Pharmacy, Mansoura University, El-Gomhoria Street, Mansour...

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Autores principales: Aman RM, Abu Hashim II, Meshali MM
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2020
Materias:
clove essential oil
biopolymers
taguchi’s model
nanoemulgel
nanofibers
anti-inflammatory activity
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/bb2c1d2764b947688c9efbe93f38213b
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spelling oai:doaj.org-article:bb2c1d2764b947688c9efbe93f38213b2021-12-02T08:05:19ZNovel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation1178-2013https://doaj.org/article/bb2c1d2764b947688c9efbe93f38213b2020-03-01T00:00:00Zhttps://www.dovepress.com/novel-clove-essential-oil-nanoemulgel-tailored-by-taguchirsquos-model--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Reham Mokhtar Aman, Irhan Ibrahim Abu Hashim, Mahasen Mohamed Meshali Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura 35516, EgyptCorrespondence: Irhan Ibrahim Abu HashimDepartment of Pharmaceutics, Faculty of Pharmacy, Mansoura University, El-Gomhoria Street, Mansoura, Dakahlia 35516, EgyptTel +20 1093008481Fax +20502247496Email irhanabuhashim@hotmail.comPurpose: Clove essential oil is a phytochemical possessing a vast array of biological activities. Nevertheless, fabricating nano topical delivery systems targeted to augment the anti-inflammatory activity of the oil has not been investigated so far. Accordingly, in this study, controlled release nanoparticulate systems, namely nanoemulgel and nanofibers (NFs), of the oil were developed to achieve such goal.Methods: The nanoemulsion was incorporated in the hydrogel matrix of mixed biopolymers – chitosan, guar gum and gum acacia – to formulate nanoemulsion-based nanoemulgel. Taguchi’s model was adopted to evaluate the effect of independently controlled parameters, namely, the concentration of chitosan (X1), guar gum (X2), and gum acacia (X3) on different dependently measured parameters. Additionally, the nanoemulsion-based NFs were prepared by the electrospinning technique using polyvinyl alcohol (PVA) polymer. Extensive in vitro, ex vivo and in vivo evaluations of the aforementioned formulae were conducted.Results: Both Fourier transform-infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC) established the complete dispersion of the nanoemulsion in the polymeric matrices of the prepared nanoemulgel and NFs. The ex vivo skin permeation data of clove essential oil from the prepared formulations showed that NFs can sustain its penetration through the skin comparably with nanoemulgel. Topical treatment with NFs (once application) and nanoemulgel (twice application) evoked a marvelous in vivo anti-inflammatory activity against croton oil-induced mouse skin inflammation model when compared with pure clove essential oil along with relatively higher efficacy of medicated NFs than that of medicated nanoemulgel. Such prominent anti-inflammatory activity was affirmed by histopathological and immunohistochemical examinations.Conclusion: These results indicated that nanoemulsion-based nanoemulgel and nanoemulsion-based NFs could be introduced to the phytomedicine field as promising topical delivery systems for effective treatment of inflammatory diseases instead of nonsteroidal anti-inflammatory drugs that possess adverse effects.Keywords: clove essential oil, biopolymers, Taguchi’s model, nanoemulgel, nanofibers, anti-inflammatory activityAman RMAbu Hashim IIMeshali MMDove Medical Pressarticleclove essential oilbiopolymerstaguchi’s modelnanoemulgelnanofibersanti-inflammatory activityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 2171-2195 (2020)
institution DOAJ
collection DOAJ
language EN
topic clove essential oil
biopolymers
taguchi’s model
nanoemulgel
nanofibers
anti-inflammatory activity
Medicine (General)
R5-920
spellingShingle clove essential oil
biopolymers
taguchi’s model
nanoemulgel
nanofibers
anti-inflammatory activity
Medicine (General)
R5-920
Aman RM
Abu Hashim II
Meshali MM
Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation
description Reham Mokhtar Aman, Irhan Ibrahim Abu Hashim, Mahasen Mohamed Meshali Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura 35516, EgyptCorrespondence: Irhan Ibrahim Abu HashimDepartment of Pharmaceutics, Faculty of Pharmacy, Mansoura University, El-Gomhoria Street, Mansoura, Dakahlia 35516, EgyptTel +20 1093008481Fax +20502247496Email irhanabuhashim@hotmail.comPurpose: Clove essential oil is a phytochemical possessing a vast array of biological activities. Nevertheless, fabricating nano topical delivery systems targeted to augment the anti-inflammatory activity of the oil has not been investigated so far. Accordingly, in this study, controlled release nanoparticulate systems, namely nanoemulgel and nanofibers (NFs), of the oil were developed to achieve such goal.Methods: The nanoemulsion was incorporated in the hydrogel matrix of mixed biopolymers – chitosan, guar gum and gum acacia – to formulate nanoemulsion-based nanoemulgel. Taguchi’s model was adopted to evaluate the effect of independently controlled parameters, namely, the concentration of chitosan (X1), guar gum (X2), and gum acacia (X3) on different dependently measured parameters. Additionally, the nanoemulsion-based NFs were prepared by the electrospinning technique using polyvinyl alcohol (PVA) polymer. Extensive in vitro, ex vivo and in vivo evaluations of the aforementioned formulae were conducted.Results: Both Fourier transform-infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC) established the complete dispersion of the nanoemulsion in the polymeric matrices of the prepared nanoemulgel and NFs. The ex vivo skin permeation data of clove essential oil from the prepared formulations showed that NFs can sustain its penetration through the skin comparably with nanoemulgel. Topical treatment with NFs (once application) and nanoemulgel (twice application) evoked a marvelous in vivo anti-inflammatory activity against croton oil-induced mouse skin inflammation model when compared with pure clove essential oil along with relatively higher efficacy of medicated NFs than that of medicated nanoemulgel. Such prominent anti-inflammatory activity was affirmed by histopathological and immunohistochemical examinations.Conclusion: These results indicated that nanoemulsion-based nanoemulgel and nanoemulsion-based NFs could be introduced to the phytomedicine field as promising topical delivery systems for effective treatment of inflammatory diseases instead of nonsteroidal anti-inflammatory drugs that possess adverse effects.Keywords: clove essential oil, biopolymers, Taguchi’s model, nanoemulgel, nanofibers, anti-inflammatory activity
format article
author Aman RM
Abu Hashim II
Meshali MM
author_facet Aman RM
Abu Hashim II
Meshali MM
author_sort Aman RM
title Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation
title_short Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation
title_full Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation
title_fullStr Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation
title_full_unstemmed Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation
title_sort novel clove essential oil nanoemulgel tailored by taguchi’s model and scaffold-based nanofibers: phytopharmaceuticals with promising potential as cyclooxygenase-2 inhibitors in external inflammation
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/bb2c1d2764b947688c9efbe93f38213b
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