HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience

Intra-hippocampal circuits are essential for associating a background context with behaviorally salient stimuli and involve cholinergic modulation at SST+ interneurons. Here the authors show that the salience of the background context memory is modulated through muscarinic activation of NPY+ hilar p...

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Autores principales: Syed Ahsan Raza, Anne Albrecht, Gürsel Çalışkan, Bettina Müller, Yunus Emre Demiray, Susann Ludewig, Susanne Meis, Nicolai Faber, Roland Hartig, Burkhart Schraven, Volkmar Lessmann, Herbert Schwegler, Oliver Stork
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/bb2ce21df8184b16927e262706f74ba5
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spelling oai:doaj.org-article:bb2ce21df8184b16927e262706f74ba52021-12-02T13:24:23ZHIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience10.1038/s41467-017-00205-32041-1723https://doaj.org/article/bb2ce21df8184b16927e262706f74ba52017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00205-3https://doaj.org/toc/2041-1723Intra-hippocampal circuits are essential for associating a background context with behaviorally salient stimuli and involve cholinergic modulation at SST+ interneurons. Here the authors show that the salience of the background context memory is modulated through muscarinic activation of NPY+ hilar perforant path associated interneurons and NPY signaling in the dentate gyrus.Syed Ahsan RazaAnne AlbrechtGürsel ÇalışkanBettina MüllerYunus Emre DemiraySusann LudewigSusanne MeisNicolai FaberRoland HartigBurkhart SchravenVolkmar LessmannHerbert SchweglerOliver StorkNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Syed Ahsan Raza
Anne Albrecht
Gürsel Çalışkan
Bettina Müller
Yunus Emre Demiray
Susann Ludewig
Susanne Meis
Nicolai Faber
Roland Hartig
Burkhart Schraven
Volkmar Lessmann
Herbert Schwegler
Oliver Stork
HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience
description Intra-hippocampal circuits are essential for associating a background context with behaviorally salient stimuli and involve cholinergic modulation at SST+ interneurons. Here the authors show that the salience of the background context memory is modulated through muscarinic activation of NPY+ hilar perforant path associated interneurons and NPY signaling in the dentate gyrus.
format article
author Syed Ahsan Raza
Anne Albrecht
Gürsel Çalışkan
Bettina Müller
Yunus Emre Demiray
Susann Ludewig
Susanne Meis
Nicolai Faber
Roland Hartig
Burkhart Schraven
Volkmar Lessmann
Herbert Schwegler
Oliver Stork
author_facet Syed Ahsan Raza
Anne Albrecht
Gürsel Çalışkan
Bettina Müller
Yunus Emre Demiray
Susann Ludewig
Susanne Meis
Nicolai Faber
Roland Hartig
Burkhart Schraven
Volkmar Lessmann
Herbert Schwegler
Oliver Stork
author_sort Syed Ahsan Raza
title HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience
title_short HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience
title_full HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience
title_fullStr HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience
title_full_unstemmed HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience
title_sort hipp neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/bb2ce21df8184b16927e262706f74ba5
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